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8 "Ye Na Kim"
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Original articles
Comparison of circuit patency and exchange rates between the original and generic versions of nafamostat mesylate in critically ill adults receiving continuous renal replacement therapy
Sujung Heo, Yanghyeon Kim, Nagyeom Lee, Ye Na Kim, Ho Sik Shin, Yeonsoon Jung, Hark Rim
Kosin Med J. 2023;38(1):36-42.   Published online March 20, 2023
DOI: https://doi.org/10.7180/kmj.22.137
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Abstract PDFPubReader   ePub   
Background
Nafamostat mesylate is widely used as an anticoagulant in continuous renal replacement therapy (CRRT). The generic versions of nafamostat mesylate have identical main components to the original product. However, it is questionable whether the generic versions have the same efficacy as the original. Therefore, we compared the circuit patency and exchange rates of the original nafamostat mesylate and a generic version to determine which is more efficient as an anticoagulant in CRRT.
Methods
This retrospective study enrolled 1,255 patients hospitalized to receive CRRT who received the original version of nafamostat mesylate or a generic version between January 2010 and July 2018. We evaluated the filter lifespan, number of filters used per day, mean blood flow, and transmembrane pressure (TMP).
Results
The mean filter lifespan was 36.3±15.1 hours in the original product group and 22.2±16.2 hours in the generic product group, which was not a statistically significant difference (p=0.060). The mean TMP was 62.2±47.3 mmHg in the original product group and 74.5±45.6 mmHg in the generic product group (p=0.045).
Conclusions
This retrospective study suggests no meaningful difference in filter lifespan between the original and generic versions of nafamostat mesylate. However, TMP was lower in the original product group than in the generic product group.
The Natural Course of Total Kidney Volume in Patients with Autosomal Dominant Polycystic Kidney Disease undergoing Hemodialysis
Ye Na Kim, Yeonsoon Jung, Ho Sik Shin, Hark Rim, Jung Gu Park, Dong Yeol Lee, Joong Kyung Kim
Kosin Med J. 2021;36(2):109-115.   Published online December 31, 2021
DOI: https://doi.org/10.7180/kmj.2021.36.2.109
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Abstract PDFPubReader   ePub   
Objectives

The natural course of native kidneys after hemodialysis initiation in patients with autosomal dominant polycystic kidney disease (ADPKD) remains poorly understood.

Methods

We measured the total volumes of native kidneys in 12 patients who had at least one enhanced computed tomography (CT) image both before and after initiation of hemodialysis (group 1) and in 18 patients who had no image before dialysis but more than two images after dialysis (group 2). In patients with images, the last image was used for analysis only after dialysis.

Results

The mean total kidney volume (TKV) (± SD) before hemodialysis initiation was 3132 ± 1413 mL and the mean TKV of the last image was 3047 ± 1323 mL in group 1. The mean TKV change rate (%) was −5.2 ± 27.4% (P > 0.05) during follow-up of 3.9 ± 1.9 years in group 1. The mean TKV change rate was 2.8 ± 34.4% (P > 0.05) in group 2. The follow-up period after dialysis initiation ranged from 4.2 ± 4.7 to 8.0 ± 5.2 years.

Conclusions

The results suggest that the TKV of native polycystic kidneys decreases substantially after hemodialysis initiation. This reduction occurs mainly during the early post-hemodialysis period and followed by a slow enlargement of TKV.

The clinical features and infectious etiologies of acute diarrhea in immunocompromised hosts
Jin Young Lee, Ye Na Kim, Namho Kim, Kyoung Soon Cho, Ji Young Park
Kosin Med J. 2017;32(2):191-203.   Published online December 29, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.2.191
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  • 3 Citations
Abstract PDFPubReader   ePub   
Objectives

The acute diarrhea is a common complaint among immunocompromised hosts, and may cause life threatening event. The infectious etiologies vary depending on virus, bacteria, and parasites. The most common etiology of acute gastroenteritis is known as enteric virus in Korea.1 But there are few studies about the infectious etiology of acute gastroenteritis in immunocompromised hosts.23 The aim of this study was to investigate the infectious etiologies of acute diarrhea in immunocompromised hosts.

Methods

Seventy three patients were enrolled prospectively in a university hospital from January 2013 to July 2014. Immunocompromised hosts included above 65-year-old people, patients with chronic diseases, solid organ or stem cell transplants, solid organ malignancies, hematologic malignancies, immunosuppressive or steroid taking patients. The clinical data were collected and stool samples collected during diarrhea were undergone laboratory analysis for enteric viruses and bacterial enteropathogens including Salmonella spp., Shigella spp., and Clostridium difficile.

Results

Fifty five patients were analyzed as follows : above 65 year-old people were 36 cases (66%), previous antibiotic usage was 22 cases (41.5%). 44 cases (81.1%) were admitted to general ward whereas 9 cases to ICU (17%). 41 cases (73.6%) were treated with antibiotics. Positive C. difficile toxin assays were 6 cases (11.9%). Other infectious etiologies were not found.

Conclusions

C. difficile infection was more common infectious etiology while enteric viruses and other bacteria are not associated with acute diarrhea among immunocompromised hosts in this study. So C. difficile infection must be considered preferentially in immunocompromised hosts with acute diarrhea.

Citations

Citations to this article as recorded by  
  • Evaluation of the detection of diarrhoea-associated RNA viruses in immunocompromised children in Iran
    Shokouh Yasaie, Seyed Dawood Mousavi Nasab, Saeed Shams, Atousa Ferdousi, Hooman Kaghazian
    Infection Prevention in Practice.2024; 6(3): 100370.     CrossRef
  • Prevalence of Human Adenovirus, Epstein-Barr Virus, and Cytomegalovirus in Pediatric Hematologic Diseases in Iran
    Shokouh Yasaie, Atousa Ferdousi, Seyed Dawood Mousavi Nasab, Hooman Kaghazian, Saeed Shams
    Infection Epidemiology and Microbiology.2024; 10(1): 51.     CrossRef
  • Mucoprotectants
    Sung Eun Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(2): 108.     CrossRef
Relationships of Total Lymphocyte Count and Subpopulation Lymphocyte Counts with the Nutritional Status in Patients Undergoing Hemodialysis/Peritoneal Dialysis
Ye Na Kim, Ho Sik Shin
Kosin Med J. 2017;32(1):58-71.   Published online January 19, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.1.58
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  • 1 Citations
Abstract PDFPubReader   ePub   
Objectives

Dialysis patients’ nutritional indicators are quite subjective and complex and cannot be easily measured in clinical settings. Based on previous reports that total lymphocyte count (TLC) and subpopulation lymphocyte counts (SLCs) are associated with nutritional status in patients with dialysis, we designed this study to examine the relationships of the TLC and SLCs with clinical outcome and nutritional status in patients undergoing maintenance hemodialysis (HD) and peritoneal dialysis (PD).

Methods

In this prospective, observational study, we enrolled 66 patients (50 HD patients and 16 PD patients) receiving stable maintenance dialysis. We evaluated the baseline parameters of height; weight; TLC; SLCs expressing CD3, CD4, CD8 and CD19; CBC; iron profile (iron, TIBC, ferritin); BUN; Cr; Na; K; total CO2; Ca; P; iPTH; protein; albumin; total cholesterol; HDL; LDL; uric acid and CRP and calculated Onodera’s prognostic nutritional index (OPNI) and the Geriatric Nutritional Risk Index (GNRI) at baseline and three months. To analyze differences in the TLC and SLCs between the HD group and the PD group, we performed an independent samples t-test. Logistic regression analysis was performed to predict malnutrition in dialysis patients. In addition, to analyze changes in TLC, SLCs expressing each marker (CD3, CD4, CD8 and CD19) and other nutritional markers, we performed general linear model (GLM)-repeated measures ANOVA.

Results

Mean age was 55.8 ± 12.7 years in HD paitents and 49.8 ± 14.5 years in PD patients. The duration of dialysis was 59.7 ± 52.9 months in HD patients and 66.1 ± 33.6 years in PD patients. Logistic regression analysis revealed that patients aged 60 years or older, women, and those whose CD19 SLCs were lower than 100 had a higher risk of developing malnutrition. In GLM-repeated measures ANOVA, CD19 SLCs were significantly higher in women and in patients with a shorter period of dialysis.

Conclusions

Our results indicate that GNRI, OPNI, TLC and SLCs (especially CD19 count) may be significant nutritional markers in HD and PD patients.

Citations

Citations to this article as recorded by  
  • Inter-correlations Among Clinical, Metabolic, and Biochemical Parameters and Their Predictive Value in Healthy and Overtrained Male Athletes: The EROS-CORRELATIONS Study
    Flavio A. Cadegiani, Claudio E. Kater
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
Herpesviridae Viral Infections Following Stem Cell Transplantation in Hematologic Malignancy
Ho Sup Lee, Hee Sang Tag, Seong Hoon Shin, Yang Soo Kim, Sung Jin Nam, Hye Soo Kim, Jin Hee Park, Su Hyeon Jeong, Sung Bin Kim, Ye Na Kim
Kosin Med J. 2010;25(1):20-26.   Published online June 30, 2010
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Usefulness of Bleeding sign by Bronchial Brushing to Detect the Site of Peripheral Pulmonary Lesions
Ye Na Kim, Su Hyeon Jeong
Kosin Med J. 2009;24(2):76-80.   Published online December 31, 2009
  • 290 View
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Case reports
A Cases of Chronic Hashimoto's Thyroiditis Associated with Hemiagenesis of Thyroid Gland
Hyun Joo Jung, Ye Na Kim, Young Sik Choi, Yo Han Park
Kosin Med J. 2009;24(1):154-156.   Published online June 30, 2009
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A Case of Foreign Body Remove with Forgatry Catheter
Ye Na Kim, Chul Ho Oak, Tae Won Jang, Man Hong Jung
Kosin Med J. 2008;23(4):243-245.   Published online December 31, 2008
  • 297 View
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KMJ : Kosin Medical Journal