The Role of Vitamin D in Menopausal Medicine

Mijin Kim; Tae-Hee Kim; Hae-Hyeog Lee; Heung Yeol Kim; Min-Jung Oh

doi:10.7180/kmj.2016.31.2.97

Articles

Page Path: HOME > Kosin Med J > Volume 31(2); 2016 > Article

Original Article The Role of Vitamin D in Menopausal Medicine: Mijin Kim¹, Tae-Hee Kim², Hae-Hyeog Lee², Heung Yeol Kim³, Min-Jung Oh⁴; Kosin Medical Journal 2016;31(2):97-102.
DOI: https://doi.org/10.7180/kmj.2016.31.2.97
Published online: January 20, 2016

¹Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Cheonon-si, Chungcheongnam-do, Korea

²Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon-si, Gyeonggi-do, Korea

³Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea

⁴Department of Life Science and Biotechnology, Soonchunhyang University College of Natural Sciences, Cheonon-si, Chungcheongnam-do, Korea

Corresponding Author: Tae-Hee Kim, Department of Obstetrics and Gynecology, Soonchunhyang University Bucheon Hospital, 170, Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14584, Korea Tel: +82-32-621-5380 Fax: +82-32-621-5016 E-mail: heeobgy@schmc.ac.kr; heeobgy@naver.com

• Received: December 16, 2015 • Accepted: January 11, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

777 Views
9 Download

Full Article

Download PDF

Abstract
References

Abstract

Menopause is the time at which menstruation stops in women. After menopause, women are more susceptible to some diseases, especially osteoporosis and cardiovascular disease. Vitamin D has a protective effect against osteoporosis by facilitating the absorption of calcium and affecting parathyroid hormone. Vitamin D also affects cardiovascular function by lowering the blood pressure, which affects the renin–angiotensin system and alters the low-density lipoprotein receptor activity. This paper discusses supplemental vitamin D in postmenopausal women with osteoporosis and cardiovascular disease.
Keywords: Cardiovascular disease; menopause; osteoporosis; vitamin D

References

1. Lips P, van Schoor NM. The effect of vitamin D on bone and osteoporosis. Best pract Res Clin Endocrinol Metab 2011;25:585–91.Article PubMed
2. Dong J, Lau CW, Wong S, Huang Y. Cardiovascular benefits of vitamin D. Sheng Li Xue Bao 2014;66:30–6.PubMed
3. Kim JS, Choi YJ, Lee KW, Song IJ, Kim CA, Son BH, et al. The study in vitamin D concentration in the blood for infants with high level of alkaline phosphatase. Kosin Med J 2012;27:17–24.Article
4. Kim TH, Lee HH, Kim JM. Letters to the Editor. Menopause 2015;22:797.Article
5. Kim TH, Lee HH, Kim JM. Comments on vitamin D. Maturitas 2015;81:329.Article PubMed
6. Han MJ, Lee JH. Factors influencing self-identity and menopausal symptoms on level of depression in middle aged women. Korean J Women Health Nurs 2013;19:275–84.Article PubMed
7. Kwak EK, Park HS, Kang NM. Menopause knowledge, attitude, symptom and management among midlife employed women. J Menopausal Med 2014;20:118–25.Article PubMed PMC
8. LeBlanc ES, Hedlin H, Qin F, Desai M, Wactawski-Wende J, Perrin N, et al. Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women's Health Initiative Trial. Maturitas 2015;81:377–83.Article PubMed PMC
9. Kim HY, Kong EH. The Association between serum GGT level and bone mineral density in postmenopausal women. Kosin Med J 2013;28:35–41.Article
10. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001;22:477–501.Article PubMed
11. Limpaphayom KK, Kim HY. Diagnosis and treatment of osteoporosis. Kosin Med J 2011;26:121–6.
12. Choi SH, Lee DJ, Kim KM, Kim BT. Association between seasonal changes in vitamin D and bone mineral density. J Korean Soc Menopause 2011;17:88–93.
13. Cândido FG, Bressan J. Vitamin D: link between osteoporosis, obesity, and diabetes? Int J Mol Sci 2014;15:6569–91.Article PubMed PMC
14. Kuchuk NO, Pluijm SM, van Schoor NM, Looman CW, Smit JH, Lips P. Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons. J Clin Endocrinol Metab 2009;94:1244–50.Article PubMed
15. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669–83.PubMed
16. Robbins JA, Aragaki A, Crandall CJ, Manson JE, Carbone L, Jackson R, et al. Women's Health Initiative clinical trials: interaction of calcium and vitamin D with hormone therapy. Menopause 2014;21:116–23.PubMed PMC
17. Chlebowski RT, Pettinger M, Johnson KC, Wallace R, Womack C, Mossavar-Rahmani Y, et al. Calcium plus vitamin D supplementation and joint symptoms in postmenopausal women in the women's health initiative randomized trial. J Acad Nutr Diet 2013;113:1302–10.Article PubMed PMC
18. Wolpin BM, Ng K, Bao Y, Kraft P, Stampfer MJ, Michaud DS, et al. Plasma 25-hydroxyvitamin D and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev 2012;21:82–91.Article PubMed
19. Norman PE, Powell JT. Vitamin D and cardiovascular disease. Circ Res 2014;114:379–93.Article PubMed
20. Li YC, Qiao G, Uskokovic M, Xiang W, Zheng W, Kong J. Vitamin D: a negative endocrine regulator of the renin–angiotensin system and blood pressure. J Steroid Biochem Mol Biol 2004;89–90:387–92.Article
21. Li YC. Vitamin D regulation of the renin–angio-tensin system. J Cell Biochem 2003;88:327–31.Article PubMed
22. Pérez-López FR. Vitamin D metabolism and cardiovascular risk factors in postmenopausal women. Maturitas 2009;62:248–62.Article PubMed
23. Kim TH, Park J, Lee HH, Lee WS, Chung SH, Park Y, et al Expression of vitamin D receptor by pulse consumption in the uterus of menopausal mouse model. J Korean Soc Menopause 2013;19:1–8.
24. Kim TH, Lee HH, Park J. Immunohistochemical detection of the 1,25-dihydroxy vitamin D receptor in the human vagina. Iran J Reprod Med 2014;12:805–10.PubMed PMC
25. Cauley JA, Chlebowski RT, Wactawski-Wende J, Robbins JA, Rodabough RJ, Chen Z, et al. Calcium plus vitamin D supplementation and health outcomes five years after active intervention ended: the Women's Health Initiative. J Womens Health (Larchmt) 2013;22:915–29.Article PubMed PMC
26. Rejnmark L, Avenell A, Masud T, Anderson F, Meyer HE, Sanders KM, et al. Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials. J Clin Endocrinol Metab 2012;97:2670–81.Article PubMed PMC

Figure & Data

References

Citations

Citations to this article as recorded by

PubReader
ePub Link
Cite

CITE

export Copy Format

Close

Download Citation

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

The Role of Vitamin D in Menopausal Medicine

Kosin Med J. 2016;31(2):97-102. Published online January 20, 2016

DOI: https://doi.org/10.7180/kmj.2016.31.2.97

XML Download