The Role of Vitamin D in Menopausal Medicine

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Kosin Med J. 2016;31(2):97-102
Publication date (electronic) : 2016 January 20
doi : https://doi.org/10.7180/kmj.2016.31.2.97
1Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Cheonon-si, Chungcheongnam-do, Korea
2Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon-si, Gyeonggi-do, Korea
3Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea
4Department of Life Science and Biotechnology, Soonchunhyang University College of Natural Sciences, Cheonon-si, Chungcheongnam-do, Korea
Corresponding Author: Tae-Hee Kim, Department of Obstetrics and Gynecology, Soonchunhyang University Bucheon Hospital, 170, Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14584, Korea Tel: +82-32-621-5380 Fax: +82-32-621-5016 E-mail: heeobgy@schmc.ac.kr; heeobgy@naver.com
Received 2015 December 16; 2015 December 16; Accepted 2015 January 11.

Abstract

Abstract

Menopause is the time at which menstruation stops in women. After menopause, women are more susceptible to some diseases, especially osteoporosis and cardiovascular disease. Vitamin D has a protective effect against osteoporosis by facilitating the absorption of calcium and affecting parathyroid hormone. Vitamin D also affects cardiovascular function by lowering the blood pressure, which affects the renin–angiotensin system and alters the low-density lipoprotein receptor activity. This paper discusses supplemental vitamin D in postmenopausal women with osteoporosis and cardiovascular disease.

References

1. Lips P, van Schoor NM. The effect of vitamin D on bone and osteoporosis. Best pract Res Clin Endocrinol Metab 2011;25:585–91.
2. Dong J, Lau CW, Wong S, Huang Y. Cardiovascular benefits of vitamin D. Sheng Li Xue Bao 2014;66:30–6.
3. Kim JS, Choi YJ, Lee KW, Song IJ, Kim CA, Son BH, et al. The study in vitamin D concentration in the blood for infants with high level of alkaline phosphatase. Kosin Med J 2012;27:17–24.
4. Kim TH, Lee HH, Kim JM. Letters to the Editor. Menopause 2015;22:797.
5. Kim TH, Lee HH, Kim JM. Comments on vitamin D. Maturitas 2015;81:329.
6. Han MJ, Lee JH. Factors influencing self-identity and menopausal symptoms on level of depression in middle aged women. Korean J Women Health Nurs 2013;19:275–84.
7. Kwak EK, Park HS, Kang NM. Menopause knowledge, attitude, symptom and management among midlife employed women. J Menopausal Med 2014;20:118–25.
8. LeBlanc ES, Hedlin H, Qin F, Desai M, Wactawski-Wende J, Perrin N, et al. Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women's Health Initiative Trial. Maturitas 2015;81:377–83.
9. Kim HY, Kong EH. The Association between serum GGT level and bone mineral density in postmenopausal women. Kosin Med J 2013;28:35–41.
10. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001;22:477–501.
11. Limpaphayom KK, Kim HY. Diagnosis and treatment of osteoporosis. Kosin Med J 2011;26:121–6.
12. Choi SH, Lee DJ, Kim KM, Kim BT. Association between seasonal changes in vitamin D and bone mineral density. J Korean Soc Menopause 2011;17:88–93.
13. Cândido FG, Bressan J. Vitamin D: link between osteoporosis, obesity, and diabetes? Int J Mol Sci 2014;15:6569–91.
14. Kuchuk NO, Pluijm SM, van Schoor NM, Looman CW, Smit JH, Lips P. Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons. J Clin Endocrinol Metab 2009;94:1244–50.
15. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669–83.
16. Robbins JA, Aragaki A, Crandall CJ, Manson JE, Carbone L, Jackson R, et al. Women's Health Initiative clinical trials: interaction of calcium and vitamin D with hormone therapy. Menopause 2014;21:116–23.
17. Chlebowski RT, Pettinger M, Johnson KC, Wallace R, Womack C, Mossavar-Rahmani Y, et al. Calcium plus vitamin D supplementation and joint symptoms in postmenopausal women in the women's health initiative randomized trial. J Acad Nutr Diet 2013;113:1302–10.
18. Wolpin BM, Ng K, Bao Y, Kraft P, Stampfer MJ, Michaud DS, et al. Plasma 25-hydroxyvitamin D and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev 2012;21:82–91.
19. Norman PE, Powell JT. Vitamin D and cardiovascular disease. Circ Res 2014;114:379–93.
20. Li YC, Qiao G, Uskokovic M, Xiang W, Zheng W, Kong J. Vitamin D: a negative endocrine regulator of the renin–angiotensin system and blood pressure. J Steroid Biochem Mol Biol 2004;89–90:387–92.
21. Li YC. Vitamin D regulation of the renin–angio-tensin system. J Cell Biochem 2003;88:327–31.
22. Pérez-López FR. Vitamin D metabolism and cardiovascular risk factors in postmenopausal women. Maturitas 2009;62:248–62.
23. Kim TH, Park J, Lee HH, Lee WS, Chung SH, Park Y, et al Expression of vitamin D receptor by pulse consumption in the uterus of menopausal mouse model. J Korean Soc Menopause 2013;19:1–8.
24. Kim TH, Lee HH, Park J. Immunohistochemical detection of the 1,25-dihydroxy vitamin D receptor in the human vagina. Iran J Reprod Med 2014;12:805–10.
25. Cauley JA, Chlebowski RT, Wactawski-Wende J, Robbins JA, Rodabough RJ, Chen Z, et al. Calcium plus vitamin D supplementation and health outcomes five years after active intervention ended: the Women's Health Initiative. J Womens Health (Larchmt) 2013;22:915–29.
26. Rejnmark L, Avenell A, Masud T, Anderson F, Meyer HE, Sanders KM, et al. Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials. J Clin Endocrinol Metab 2012;97:2670–81.

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