Skip Navigation
Skip to contents

KMJ : Kosin Medical Journal

OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > Kosin Med J > Volume 31(2); 2016 > Article
Case Report
A Case of Cerebral Venous Thrombosis in a Patient with Graves' Disease
Bo Ra Kim1, Jung Hwa Jung1,2, Jong Ryeal Hahm1,2, Jaehoon Jung1,2, Hee Jung Park1, Soo Kyoung Kim1,2
Kosin Medical Journal 2016;31(2):179-183.
DOI: https://doi.org/10.7180/kmj.2016.31.2.179
Published online: January 20, 2016

1Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Gyeongsangnam-do, Korea

2Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Gyeongsangnam-do, Korea

Corresponding Author: Soo Kyoung Kim, Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, 79, Gangnam-ro, Jinju-si, Gyeongsangnam-do 52727, Korea TEL: +82-55-750-8874 FAX: +82-55-758-9122 E-mail: 9854008@naver.com
• Received: July 14, 2015   • Accepted: July 21, 2015

Copyright © 2016 Kosin University School of Medicine Proceedings

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • 1,223 Views
  • 3 Download
  • 1 Crossref
  • Superior sagittal sinus thrombosis is an uncommon disease, and 25% of cases are considered to be idiopathic. Hypercoagulability, local bloodstream stasis, and vessel wall abnormalities may contribute to the development of this condition. The thyrotoxic phase of Graves' disease is associated with venous thrombosis caused by hypercoagulability, which is in turn induced by increased levels of homocysteine and factor VIII and decreased fibrinolytic activity. Here, we report the case of a 39-year-old male who presented with superior sagittal sinus thrombosis and concomitant hyperthyroidism.
Fig. 1.
Fluid-attenuated inversion recovery (FLAIR, A) and diffusion-2 weighted MR images(DWI, B) demonstrate multiple hyperintense lesions in both high frontal cortices (arrows). The lesions are more clearly demonstrated on DWI (B) than on FLAIR image (A).
kmj-31-179f1.jpg
Fig. 2.
Brain computed tomography (CT) angiography shows segmental 2 occlusion of the superior sagittal sinus due to thrombosis (arrows).
kmj-31-179f2.jpg
  • 1. Allroggen H, Abbott RJ. Cerebral venous sinus thrombosis. Postgrad Med J 2000;76:12–5.ArticlePubMedPMC
  • 2. Stam J. Cerebral venous and sinus thrombosis: incidence and causes. Adv Neurol 2003;92:225–32.PubMed
  • 3. Squizzato A, Gerdes VE, Brandjes DP, Büller HR, Stam J. Thyroid diseases and cerebrovascular disease. Stroke 2005;36:2302–10.ArticlePubMed
  • 4. Erem C, Ersoz HO, Karti SS, Ukinç K, Hacihasanoglu A, Değer O, et al. J Blood coagulation and fibrinolysis in patients with hyperthyroidism. Endocrinol Invest 2002;25:345–50.
  • 5. Siegert CE, Smelt AH, de Bruin TW. Superior sagittal sinus thrombosis and thyrotoxicosis. Possible association in two cases. Stroke 1995;26:496–7.ArticlePubMed
  • 6. Ra CS, Lui CC, Liang CL, Chen HJ, Kuo YL, Chen WF. Superior sagittal sinus thrombosis induced by thyrotoxicosis. Case report. J Neurosurg 2001;94:130–2.PubMed
  • 7. Verberne HJ, Fliers E, Prummel MF, Stam J, Brandjes DP, Wiersinga WM. Thyrotoxicosis as a predisposing factor for cerebral venous thrombosis. Thyroid 2000;10:607–10.ArticlePubMed
  • 8. Colleran KM, Ratliff DM, Burge MR. Potential association of thyrotoxicosis with vitamin B and folate deficiencies, resulting in risk for hyperhomocysteinemia and subsequent thromboembolic events. Endocr Pract 2003;9:290–5.ArticlePubMed
  • 9. Coutinho JM, Zuurbier SM, Stam J. Declining mortality in cerebral venous thrombosis: a systematic review. Stroke 2014;45:1338–41.ArticlePubMed
  • 10. Franchini M, Lippi G, Targher G. Hyperthy roidism and venous thrombosis: a casual or causal association? A systematic literature review. Clin Appl Thromb Hemost 2011;17:387–92.ArticlePubMed
  • 11. Bensalah M, Squizzato A, Ould Kablia S, Menia H, Kemali Z. Cerebral vein and sinus thrombosis and hyperthyrodism: a case report and a systematic review of the literature. Thromb Res 2011;128:98–100.ArticlePubMed
  • 12. Kim DD, Chunilal S, Young S, Cutfield R. A study of venous thrombosis incidence in patients with acute hyperthyroidism. Intern Med J 2013;43:361–5.ArticlePubMed
  • 13. Lin HC, Yang LY, Kang JH. Increased risk of pulmonary embolism among patients with hyperthyroidism: a 5-year follow-up study. J Thromb Haemost 2010;8:2176–81.ArticlePubMed
  • 14. Grine S, Charfi N, Kamoun M, Mnif F, Naceur BB, Rekik N, et al. Hyperthyroidism: A rare cause of pulmonary embolism: Report of two cases. Indian J Endocrinol Metab 2013;17:1104–7.ArticlePubMedPMC
  • 15. Squizzato A, Romualdi E, Büller HR, Gerdes VE. Clinical review: Thyroid dysfunction and effects on coagulation and fibrinolysis: a systematic review. J Clin Endocrinol Metab 2007;92:2415–20..
  • 16. Lippi G, Franchini M, Targher G, Montagnana M, Salvagno GL, Guidi GC, et al. Hyperthyroidism is associated with shortened APTT and increased fibrinogen values in a general population of unselected outpatients. J Thromb Thrombolysis 2009;28:362–5.ArticlePubMed
  • 17. Molloy E, Cahill M, O'Hare JA. Cerebral venous sinus thrombosis precipitated by Graves' disease and Factor V Leiden mutation. Ir Med J 2003;96:46–7.

Figure & Data

References

    Citations

    Citations to this article as recorded by  
    • Cerebral Venous Thrombosis during Thyrotoxicosis: Case Report and Literature Update
      Emanuela Maria Raho, Annibale Antonioni, Niccolò Cotta Ramusino, Dina Jubea, Daniela Gragnaniello, Paola Franceschetti, Francesco Penitenti, Andrea Daniele, Maria Chiara Zatelli, Maurizio Naccarato, Ilaria Traluci, Maura Pugliatti, Marina Padroni
      Journal of Personalized Medicine.2023; 13(11): 1557.     CrossRef

    • PubReader PubReader
    • ePub LinkePub Link
    • Cite
      CITE
      export Copy
      Close
    • Download Citation
      Download Citation
      Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

      Format:
      • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
      • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
      Include:
      • Citation for the content below
      A Case of Cerebral Venous Thrombosis in a Patient with Graves' Disease
      Kosin Med J. 2016;31(2):179-183.   Published online January 20, 2016
      Close
    • XML DownloadXML Download
    Figure

    KMJ : Kosin Medical Journal