A Case of Cerebral Venous Thrombosis in a Patient with Graves' Disease

Article information

Kosin Med J. 2016;31(2):179-183

Publication date (electronic) : 2016 January 20

doi : https://doi.org/10.7180/kmj.2016.31.2.179

Bo Ra Kim ¹, Jung Hwa Jung ¹^,², Jong Ryeal Hahm ¹^,², Jaehoon Jung ¹^,², Hee Jung Park ¹, Soo Kyoung Kim ¹^,²^,

¹Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Gyeongsangnam-do, Korea

²Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Gyeongsangnam-do, Korea

Corresponding Author: Soo Kyoung Kim, Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, 79, Gangnam-ro, Jinju-si, Gyeongsangnam-do 52727, Korea TEL: +82-55-750-8874 FAX: +82-55-758-9122 E-mail: 9854008@naver.com

Received 2015 July 14; 2015 July 17; Accepted 2015 July 21.

Abstract

Superior sagittal sinus thrombosis is an uncommon disease, and 25% of cases are considered to be idiopathic. Hypercoagulability, local bloodstream stasis, and vessel wall abnormalities may contribute to the development of this condition. The thyrotoxic phase of Graves' disease is associated with venous thrombosis caused by hypercoagulability, which is in turn induced by increased levels of homocysteine and factor VIII and decreased fibrinolytic activity. Here, we report the case of a 39-year-old male who presented with superior sagittal sinus thrombosis and concomitant hyperthyroidism.

Keywords: Cerebral venous thrombosis; Thyrotoxicosis; Protein C Deficiency

Fig. 1.

Fluid-attenuated inversion recovery (FLAIR, A) and diffusion-2 weighted MR images(DWI, B) demonstrate multiple hyperintense lesions in both high frontal cortices (arrows). The lesions are more clearly demonstrated on DWI (B) than on FLAIR image (A).

Fig. 2.

Brain computed tomography (CT) angiography shows segmental 2 occlusion of the superior sagittal sinus due to thrombosis (arrows).

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Fig. 1.

Fig. 2.

Brain computed tomography (CT) angiography shows segmental 2 occlusion of the superior sagittal sinus due to thrombosis (arrows).