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HOME > Kosin Med J > Volume 30(2); 2015 > Article
Case Report
A Case of Disseminated Extranodal Interdigitating Dendritic Cell Sarcoma Arising from Parotid Gland
Young Hoon Park1, Shin Il Kim1, Suk Jin Choi2, Joo Han Lim1, Hyeon Gyu Yi1, Moon Hee Lee1, Chul Soo Kim1
Kosin Medical Journal 2015;30(2):163-169.
DOI: https://doi.org/10.7180/kmj.2015.30.2.163
Published online: January 20, 2015

1Department of Internal Medicine and School of Medicine, Incheon, Korea

2Department of Pathology, Inha University Hospital and School of Medicine, Incheon, Korea

Corresponding Author: Chul Soo Kim, Department of Internal Medicine, Inha University Hospital and School of Medicine, 27, Inhang-ro, Jung-gu, Incheon 22332, Korea Tel: +82-32-890-2588 Fax: +82-32-890-2585 E-mail: cskimmd@inha.ac.kr
• Received: September 24, 2014   • Accepted: November 1, 2014

Copyright © 2015 Kosin University School of Medicine Proceedings

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare tumor derived from professional antigen presenting cell and primarily found in lymph nodes, with rarer case report about extranodal presentation of IDCS. A 71-yr-old man was admitted with progressively enlarging and painless mass in the right parotid area for 2 months. Computed tomography of the neck and chest revealed enhancing mass in right parotid gland, multiple lymphadenopathies around neck and mediastinum, and an osteolytic metastasis at thoracic spine. Morphological and immunohistochemical analysis of an excisional biopsy specimen from parotid mass were consistent with a diagnosis of IDCS. Palliative chemotherapy with 6 cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) regimen and 2 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) regimen plus radiotherapy on parotid mass failed in tumor reduction. We describe a rare case of disseminated extranodal IDCS arising from parotid gland.
  • Keywords: disseminated; interdigitating dendritic cell sarcoma; parotid gland
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Table 1.
Demographic and clinical features of reported and Korean cases.
  Reported cases (N = 100) Korean cases (N = 5)
Age    
Median (range), yr 56.5 (1.8 – 88) 57 (32 – 73)
Sex    
Male:female (ratio) 58:42 (1.38:1) 2:3 (1:1.5)
Presentationa    
Localized 59% (45/76) 20% (1/5)
Locally advanced 5.3% (4/76) 40% (2/5)
Metastatic 35.6% (27/76) 40% (2/5)
Involved sites (number of cases)    
Lymph nodes    
Cervical 41 2
Axillary 22 2
Mediastinal 9 –
Intraabdominal 18 –
Exrtanodal sites    
Tonsil 3 1
Nasopharynx 3 2
Soft tissue 1 1
Bone 5 1
Pleura 3 1
Treatment (number of cases)a    
Surgery alone 21/76 –
Surgery plus adjuvant therapy 18/76 1/5
Radiation therapy alone 6/76 1/5
Chemotherapy alone 26/76 2/5
Chemotherapy plus radiation therapy 2/76 1/5
No treatment 2/76 –
Unknown 1/76 –

aData obtained from 76 out of 100 reported cases were analyzed.

  • 1. Kairouz S, Hashash J, Kabbara W, McHayleh W, Tabbara IA. Dendritic cell neoplasms: an overview. Am J Hematol 2007;82:924–8.ArticlePubMed
  • 2. Saygin C, Uzunaslan D, Ozguroglu M, Senocak M, Tuzuner N. Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series Crit Rev.
  • 3. Han HS, Lee OJ, Lim SN, An JY, Lee KM, Choe KH, al. Extranodal interdigitating dendritic cell sarcoma presenting in the pleura: a case report. J Korean Med Sci 2011;26:304–7.ArticlePubMedPMCPDF
  • 4. Kim SY, Kang JH, Chun SH, Chang MH, Kim YS, Lee SN, et al. Interdigitating dendritic cell sarcoma of the tonsil. Asia Pac J Clin Oncol 2010;6:144–8.ArticlePubMed
  • 5. Lee SY, Lee SR, Chang WJ, Kim HS, Kim BS, Kim IS. Successful treatment of disseminated interdigitating dendritic cell sarcoma with adriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy. Korean J Hematol 2012;47:150–3.ArticlePubMedPMC
  • 6. Lee EJ, Hyun DW, Cho HY, Lee JG. A Rare Case of Interdigitating Dendritic Cell Sarcoma in the Nasal Cavity. Case Rep Otolaryngol 2013;2013:913157.ArticlePubMedPMC
  • 7. Han SW, Kim ZS, Kim HM, Lee J, Kang GH, Cho HD, et al. Interdigitating dendritic cell sarcoma occurred alone in axilla. J Korean Surg Soc 2012;82:330–4.ArticlePubMedPMC
  • 8. Efune G, Sumer BD, Sarode VR, Wang HY, Myers LL. Interdigitating dendritic cell sarcoma of the parotid gland: case report and literature review. Am J Otolaryngol 2009;30:264–8.ArticlePubMed
  • 9. Schraven SP, Plontke SK, Syha R, Fend F, Wolburg H, Adam P. Dendritic cell tumor in a salivary gland lymph node: a rare differential diagnosis of salivary gland neoplasms. Diagn Pathol 2011;6:94.ArticlePubMedPMC
  • 10. De Pas T, Spitaleri G, Pruneri G, Curigliano G, Noberasco C, Luini A, et al. Dendritic cell sarcoma: an analytic overview of the literature and presentation of original five cases. Crit Rev Oncol Hematol 2008;65:1–7.ArticlePubMed
  • 11. Pileri SA, Grogan TM, Harris NL, Banks P, Campo E, Chan JK, et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology 2002;41:1–29.ArticlePubMed
  • 12. Ralfkiaer E, Delsol G, O'Connor NT, Brandtzaeg P, Brousset P, Vejlsgaard GL, et al. Malignant lymphomas of true histiocytic origin. A clinical, histological, immunophenotypic and genotypic study. J Pathol 1990;160:9–17.ArticlePubMed
  • 13. Barwell N, Howatson R, Jackson R, Johnson A, Jarrett RF, Cook G. Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection. J Clin Pathol 2004;57:87–9.ArticlePubMedPMC

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    • Interdigitating dendritic cell sarcoma involving head and neck region- a report of four cases with review of literature
      Archana Lakshmanan, Ann Kurian, S. Annapurneswari
      Human Pathology: Case Reports.2021; 24: 200514.     CrossRef
    • New insights inside the interdigitating dendritic cell sarcoma—pooled analysis and review of literature
      Amr Muhammed, Ahmed R. H. Ahmed, Hashem Maysa, Ahmed E. S. Mohamed, Asmaa Abd-ElGhany Abd-ElLateef, Esraa Elnakib
      Annals of Hematology.2019; 98(12): 2641.     CrossRef

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      A Case of Disseminated Extranodal Interdigitating Dendritic Cell Sarcoma Arising from Parotid Gland
      Kosin Med J. 2015;30(2):163-169.   Published online January 20, 2015
      DOI: https://doi.org/10.7180/kmj.2015.30.2.163
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    A Case of Disseminated Extranodal Interdigitating Dendritic Cell Sarcoma Arising from Parotid Gland
    Image Image Image
    Fig. 1.  
    Fig. 2.  
    Fig. 3.  

    Fig. 1.

    Fig. 2.

    Fig. 3.

    A Case of Disseminated Extranodal Interdigitating Dendritic Cell Sarcoma Arising from Parotid Gland

    Demographic and clinical features of reported and Korean cases.

      Reported cases (N = 100) Korean cases (N = 5)
    Age    
    Median (range), yr 56.5 (1.8 – 88) 57 (32 – 73)
    Sex    
    Male:female (ratio) 58:42 (1.38:1) 2:3 (1:1.5)
    Presentationa    
    Localized 59% (45/76) 20% (1/5)
    Locally advanced 5.3% (4/76) 40% (2/5)
    Metastatic 35.6% (27/76) 40% (2/5)
    Involved sites (number of cases)    
    Lymph nodes    
    Cervical 41 2
    Axillary 22 2
    Mediastinal 9 –
    Intraabdominal 18 –
    Exrtanodal sites    
    Tonsil 3 1
    Nasopharynx 3 2
    Soft tissue 1 1
    Bone 5 1
    Pleura 3 1
    Treatment (number of cases)a    
    Surgery alone 21/76 –
    Surgery plus adjuvant therapy 18/76 1/5
    Radiation therapy alone 6/76 1/5
    Chemotherapy alone 26/76 2/5
    Chemotherapy plus radiation therapy 2/76 1/5
    No treatment 2/76 –
    Unknown 1/76 –
    Table 1. Demographic and clinical features of reported and Korean cases.

    Data obtained from 76 out of 100 reported cases were analyzed.

    Table 1.

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