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Case Report
A Case of Disseminated Extranodal Interdigitating Dendritic Cell Sarcoma Arising from Parotid Gland - Young Hoon Park1, Shin Il Kim1, Suk Jin Choi2, Joo Han Lim1, Hyeon Gyu Yi1, Moon Hee Lee1, Chul Soo Kim1
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Kosin Medical Journal 2015;30(2):163-169.
DOI: https://doi.org/10.7180/kmj.2015.30.2.163
Published online: January 20, 2015
1Department of Internal Medicine and School of Medicine, Incheon, Korea
2Department of Pathology, Inha University Hospital and School of Medicine, Incheon, Korea
- Corresponding Author: Chul Soo Kim, Department of Internal Medicine, Inha University Hospital and School of Medicine, 27, Inhang-ro, Jung-gu, Incheon 22332, Korea Tel: +82-32-890-2588 Fax: +82-32-890-2585 E-mail: cskimmd@inha.ac.kr
• Received: September 24, 2014 • Accepted: November 1, 2014
Copyright © 2015 Kosin University School of Medicine Proceedings
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Abstract
- Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare tumor derived from professional antigen presenting cell and primarily found in lymph nodes, with rarer case report about extranodal presentation of IDCS. A 71-yr-old man was admitted with progressively enlarging and painless mass in the right parotid area for 2 months. Computed tomography of the neck and chest revealed enhancing mass in right parotid gland, multiple lymphadenopathies around neck and mediastinum, and an osteolytic metastasis at thoracic spine. Morphological and immunohistochemical analysis of an excisional biopsy specimen from parotid mass were consistent with a diagnosis of IDCS. Palliative chemotherapy with 6 cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) regimen and 2 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) regimen plus radiotherapy on parotid mass failed in tumor reduction. We describe a rare case of disseminated extranodal IDCS arising from parotid gland.
Table 1.Demographic and clinical features of reported and Korean cases.
| Reported cases (N = 100) | Korean cases (N = 5) | |
|---|---|---|
| Age | ||
| Median (range), yr | 56.5 (1.8 – 88) | 57 (32 – 73) |
| Sex | ||
| Male:female (ratio) | 58:42 (1.38:1) | 2:3 (1:1.5) |
| Presentationa | ||
| Localized | 59% (45/76) | 20% (1/5) |
| Locally advanced | 5.3% (4/76) | 40% (2/5) |
| Metastatic | 35.6% (27/76) | 40% (2/5) |
| Involved sites (number of cases) | ||
| Lymph nodes | ||
| Cervical | 41 | 2 |
| Axillary | 22 | 2 |
| Mediastinal | 9 | – |
| Intraabdominal | 18 | – |
| Exrtanodal sites | ||
| Tonsil | 3 | 1 |
| Nasopharynx | 3 | 2 |
| Soft tissue | 1 | 1 |
| Bone | 5 | 1 |
| Pleura | 3 | 1 |
| Treatment (number of cases)a | ||
| Surgery alone | 21/76 | – |
| Surgery plus adjuvant therapy | 18/76 | 1/5 |
| Radiation therapy alone | 6/76 | 1/5 |
| Chemotherapy alone | 26/76 | 2/5 |
| Chemotherapy plus radiation therapy | 2/76 | 1/5 |
| No treatment | 2/76 | – |
| Unknown | 1/76 | – |
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- Interdigitating dendritic cell sarcoma involving head and neck region- a report of four cases with review of literature
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