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Considerations for experimental animal ethics in the research planning and evaluation process
Jaewon Shim, Jeongtae Kim
Kosin Med J. 2022;37(4):271-277.   Published online December 22, 2022
DOI: https://doi.org/10.7180/kmj.22.139
  • 4,897 View
  • 141 Download
  • 2 Citations
Abstract PDFPubReader   ePub   
Research using experimental animals has substantially contributed to advances in science and medicine. Animal experiments are nearly essential for biomedical research and development efforts. Because many animals are sacrificed, researchers should consider the welfare of experimental animals and related ethical issues, along with the successful results of their experiments. This review introduces the criteria that should be considered in terms of experimental animal ethics, based on the principles of the 3 R’s: replacement, representing careful consideration of the need for animal experiments; reduction, representing the use of the minimal number of animals to obtain meaningful experimental results; and refinement, representing continuous effects to find alternative methods to reduce pain and distress in experimental animals. Based on these principles, the following points should be considered when planning experiments: the necessity of animal experiments; alternatives to animal experiments; the relevance of the species and numbers of experimental animals; appropriate assessment and management of pain; the proper usage of sedatives, painkillers, and anesthesia; and valid timing for humane endpoints and euthanasia. These criteria are beneficial for both experimental animals and researchers because careful handling to ensure experimental animal welfare guarantees that scientific research will yield convincing, repeatable, and accurate results.

Citations

Citations to this article as recorded by  
  • Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells
    Eun-Ji Ko, Do-Ye Kim, Min-Hye Kim, Hyojin An, Jeongtae Kim, Jee-Yeong Jeong, Kyoung Seob Song, Hee-Jae Cha
    International Journal of Molecular Sciences.2024; 25(2): 833.     CrossRef
  • General Principles, Designs, and Statistical Analyses in Experimental Animal Studies
    Şengül Cangür
    Düzce Tıp Fakültesi Dergisi.2024;[Epub]     CrossRef
Ethical issues in clinical research and publication
Hyoung Shin Lee
Kosin Med J. 2022;37(4):278-282.   Published online December 15, 2022
DOI: https://doi.org/10.7180/kmj.22.132
  • 4,569 View
  • 176 Download
  • 7 Citations
Abstract PDFPubReader   ePub   
Clinical research including human participants should be based on truth, demonstrate scientific integrity, and follow ethical standards and guidelines to protect study participants. The publication of clinical research should be transparent and adhere to strict criteria for authorship. A thorough understanding and knowledge of ethical issues will limit investigator misconduct in clinical research and publication. In this article, basic ethical issues in clinical research and publication are reviewed and summarized based on recent guidelines.

Citations

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  • Squamous cell carcinoma of the pancreas with a pancreatic intraductal papillary mucinous neoplasm: a case report
    Nam Kyung Lee
    Kosin Medical Journal.2024; 39(1): 71.     CrossRef
  • Clinical efficacy and safety of autologous serum intramuscular injection in patients with mild-to-moderate atopic dermatitis: a prospective, open-label, uncontrolled study
    Gil-Soon Choi, Jong Bin Park, Young-Ho Kim, Hee-Kyoo Kim
    Kosin Medical Journal.2024; 39(1): 51.     CrossRef
  • Surgical management of giant adrenal myelolipoma using a modified Makuuchi incision: a case report
    Byeong Jin Kang, Seung Hyeon Kim, Kyoungha Jang, Kyung Hwan Kim, Hong Koo Ha
    Kosin Medical Journal.2024; 39(1): 75.     CrossRef
  • Evaluating the Potential of Immersive Virtual Reality-Based Serious Games Interventions for Autism: A Pocket Guide Evaluation Framework
    Sara Peretti, Maria Chiara Pino, Federica Caruso, Tania Di Mascio
    Education Sciences.2024; 14(4): 377.     CrossRef
  • Informed Consent in Clinical Studies in the Republic of Srpska
    Snežana Pantović, Dijana Zrnić
    Review of European and Comparative Law.2024;[Epub]     CrossRef
  • Clinical outcomes of prostate artery embolization for management of benign prostate hyperplasia (prostate larger than 100 mL) with or without hematuria
    Soodong Kim
    Kosin Medical Journal.2023; 38(4): 259.     CrossRef
  • Basic knowledge of endoscopic retrograde cholangiopancreatography
    Jung Wook Lee
    Kosin Medical Journal.2023; 38(4): 241.     CrossRef
How to conduct well-designed clinical research
Da Jung Kim, Song Yi Kil, Jongwon Son, Ho Sup Lee
Kosin Med J. 2022;37(3):187-191.   Published online September 27, 2022
DOI: https://doi.org/10.7180/kmj.22.122
  • 2,314 View
  • 65 Download
  • 6 Citations
Abstract PDFPubReader   ePub   
Clinicians and healthcare decision-makers conduct their clinical practice based on the results of clinical trials. However, some health problems remain unresolved; in such cases, further research is required. To ensure reliable research results, it is important to understand the study design and conduct well-designed clinical trials. Many study designs can be chosen within the two broad categories of observational and interventional. Clinical studies have a variety of designs, including case series, case-control, cross-sectional, and prospective and retrospective cohort studies. Well-designed clinical studies can clarify important differences between treatment options and provide data on long-term drug efficacy and safety. Interpreting the results of clinical trials can be difficult because weaknesses in research design, data collection methods, analytic methods, and reporting can compromise their value and usefulness. However, although randomized controlled trials are limited owing to ethical and practical issues, they are optimal for investigating the effects of therapy and establishing causality. Here we present an overview of different clinical research designs and review their advantages and limitations.

Citations

Citations to this article as recorded by  
  • Gastric cancer and metabolic syndrome
    Hyeong Ho Jo
    Kosin Medical Journal.2024; 39(1): 26.     CrossRef
  • Clinical efficacy and safety of autologous serum intramuscular injection in patients with mild-to-moderate atopic dermatitis: a prospective, open-label, uncontrolled study
    Gil-Soon Choi, Jong Bin Park, Young-Ho Kim, Hee-Kyoo Kim
    Kosin Medical Journal.2024; 39(1): 51.     CrossRef
  • Changes in parents’ health concerns by post-preterm birth period in South Korea: a cross-sectional study
    Yu Jin Jung, Hun Ha Cho
    Child Health Nursing Research.2024; 30(2): 118.     CrossRef
  • Basic knowledge of endoscopic retrograde cholangiopancreatography
    Jung Wook Lee
    Kosin Medical Journal.2023; 38(4): 241.     CrossRef
  • Evaluation of automated calibration and quality control processes using the Aptio total laboratory automation system
    Namhee Kim, Yein Kim, Jeongeun Park, Jungsoo Choi, Hyunyong Hwang
    Kosin Medical Journal.2022; 37(4): 342.     CrossRef
  • The effects of rebamipide, sucralfate, and rifaximin against inflammation and apoptosis in radiation-induced murine intestinal injury
    Won Moon, Sangwook Lim, Yeonsoon Jung, Yuk Moon Heo, Seun Ja Park, Moo In Park, Sung Eun Kim, Jae Hyun Kim, Kyoungwon Jung
    Kosin Medical Journal.2022; 37(4): 320.     CrossRef
Uterine leiomyoma research
Tae Hee Kim, Hae Hyeog Lee
Kosin Med J. 2015;30(1):13-22.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.1.13
  • 1,083 View
  • 15 Download
  • 1 Citations
Abstract PDFPubReader   ePub   
Abstract

Uterine leiomyoma is the most common type of benign tumor in women of reproductive age. This disease is rare before menarche, and its incidence decreases after menopause. Uterine leiomyoma is known to be related to hormonal changes, but the precise underlying mechanism has yet to be determined. Although it is a benign disease, the most common form of management involves surgical intervention. Uterine leiomyoma is also related to infertility and obstetric complications. Here, we present a review of the literature regarding uterine leiomyoma and discuss management of this disease.

Citations

Citations to this article as recorded by  
  • Uterine cancer and ezrin expression
    Kim Yeon-Suk, Kim Tae-Hee, Lee Hae-Hyeog, Kim Heung Yeol, Jang Dahyae, Lee Arum
    Kosin Medical Journal.2016; 31(1): 5.     CrossRef

KMJ : Kosin Medical Journal