Skip Navigation
Skip to contents

KMJ : Kosin Medical Journal

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
11 "Metabolic syndrome"
Filter
Filter
Article category
Keywords
Publication year
Authors
Review articles
Gastric cancer and metabolic syndrome
Hyeong Ho Jo
Kosin Med J. 2024;39(1):26-34.   Published online March 22, 2024
DOI: https://doi.org/10.7180/kmj.24.108
  • 41 View
  • 2 Download
Abstract PDFPubReader   ePub   
Gastric cancer (GC), a prevalent disease in Asian countries, presents a substantial global health challenge. The risk factors for GC include Helicobacter pylori infection, diet, smoking, alcohol, and metabolic syndrome (MetS). This review meticulously examines the intricate connections between MetS and GC, focusing on visceral adipocytes, hormonal factors, obesity, and their impact on survival outcomes. Visceral adipocytes, which secrete inflammatory cytokines and hormones, play a pivotal role in influencing cancer development. Hormonal factors demonstrate nuanced associations with specific GC subtypes, underscoring the complexity of their impact. Large-scale studies exploring obesity-related factors reveal sex-specific nuances and underscore the importance of considering overall weight and body composition. Furthermore, the review explores the impact of eradication therapy for H. pylori infection, which is the most significant factor in the onset of GC, on the components of MetS. Additionally, the influence of MetS on postoperative outcomes and survival in GC patients highlights the interplay between therapeutic interventions and lifestyle factors. This comprehensive exploration sheds light on the multifaceted relationship between MetS and GC, providing valuable insights for future research and preventive strategies.
Exploring the nexus between obesity, metabolic syndrome, and colorectal cancer
Jong Yoon Lee
Kosin Med J. 2024;39(1):18-25.   Published online March 12, 2024
DOI: https://doi.org/10.7180/kmj.24.107
  • 78 View
  • 3 Download
Abstract PDFPubReader   ePub   
The increasing global prevalence of obesity and metabolic syndrome (MetS) is strongly associated with the incidence of colorectal cancer (CRC). Obesity and MetS detrimentally impact the treatment outcomes of CRC and share similar mechanisms that contribute to the development of CRC. Increased insulin resistance in patients with obesity is linked to CRC, and altered levels of sex hormones and adipokines affect cell growth and inflammation. Obesity and MetS also alter the gut microbiome. Bile acids, which are crucial for lipid metabolism, are elevated in patients with obesity. Moreover, specific bile acids are associated with colonic damage, inflammation, and the development of CRC. Obesity and MetS increase the risk of postoperative complications and affect the response to chemotherapy. The promotion of weight loss and the resolution of MetS can reduce the occurrence of CRC and increase treatment efficacy. Therefore, it is imperative to implement appropriate management strategies to address obesity and MetS with the aim of improving the prognosis and reducing the incidence of CRC. Moreover, additional research should be conducted to determine the optimal timing for tailored CRC screening in patients with obesity or MetS. In this review, we explore the impact of obesity and MetS on the development of CRC and examine potential strategies to mitigate CRC risk in individuals with obesity and MetS.
Original articles
The significance of blood pressure variation and metabolic risk factors in patients with different stages of hypertension
Sun Min Kim, In Kyoung Shim, Ju Won Lee, Jun Yeob Lee, Si Won Lee, Kyoung Im Cho, Hyun Su Kim, Jae Woo Lee, Jung Ho Heo
Kosin Med J. 2017;32(2):179-190.   Published online December 29, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.2.179
  • 1,038 View
  • 2 Download
Abstract PDFPubReader   ePub   
Objectives

Blood pressure variation (BPV) and metabolic syndrome is an independent risk factor for cardiovascular events. Ambulatory blood Pressure (ABP) has been shown to be more closely related to cardiovascular events in hypertensive patients than conventional office BP (OBP). Using both OBP and ABP, 4 groups of patients were identified: (1) normotensive patients (NT); (2) white coat hypertensives (WCHT); (3) masked hypertensives (MHT); and (4) sustainedhypertensives (SHT). We investigated the significance of BPV and metabolic risks of these 4 groups.

Methods

This study is a retrospective analysis of patients between January 2008 and May 2013. Echocardiography and 24 hour ABP monitoring were performed.

Results

BMI was significantly higher in the MHT compared with the NT. There were progressive increases in fasting glucose level from NT to WCHT, MHT, and SHT.MHT and SHT had higher 24h and nighttime BPV than NT.MHT was significantly related with BMI (r = 0.139, P = 0.010), creatinine (r = 0.144, P = 0.018), fasting glucose (r = 0.128, P = 0.046), daytime systolic BPV (r = 0.130, P = 0.017), and daytime diastolic BPV (r = 0.130, P = 0.017). Dyslipidemia (r = 0.110, P = 0.043), nighttime systolic BPV (r = 0.241, P < 0.001) and nighttime diastolic BPV (r = 0.143, P = 0.009) shown correlation with SHT. In multivariate logistic regression, MHT was independently associated with Body mass index (OR 1.086, 95% CI 1.005–1.174, P = 0.038) and creatinine (OR 1.005, 95% CI 1.001–1.010, P = 0.045).

Conclusions

BPV and metabolic risk factors were found to be greater in MHT and SHT compared with NT and WCHT. This suggests that BPV and metabolic risks may contribute to the elevated cardiovascular risk observed in patients with MHT and SHT.

Relationship with Metabolic Syndrome by Grade of Nonalcoholic Fatty Livers
Eun Hee Kong
Kosin Med J. 2009;24(2):103-108.   Published online December 31, 2009
  • 212 View
  • 0 Download
PDF
Relationship of the G-250A Polymorphism of the Human Hepatic Lipase Gene Promoter with Metabolic Syndrome in Koreans
Myung Chul Kim, Myeong Sook Lee, Byeng Chul Yu, Yong Hwan Lee
Kosin Med J. 2007;22(2):47-55.   Published online December 31, 2007
  • 196 View
  • 0 Download
PDF
Comparison of the Prevalence of the Metabolic Syndrome Using Two Proposed Definitions
Jeong Sik Lee, Mi Hong Jeong, Myeong Sook Lee, Byeng Chul Yu, Yong Hwan Lee
Kosin Med J. 2007;22(1):34-42.   Published online June 30, 2007
  • 237 View
  • 0 Download
PDF
The Relationship between Gamma-Glutamyltransferase and Metabolic Syndrome in the Non Alcoholic Health Screen Examinees
Ji Eun Park, Nang Hee Kim, Ji Hyun Nam, Ju Hun Kim, Jung Pil Park, Young Sik Choi, Yo Han Park, Jin Ha Kim
Kosin Med J. 2005;20(1):38-45.
  • 224 View
  • 2 Download
PDF
The relationship between FattyLiver and Parameters of Metabolic Syndrome in the Non Alcoholic Health Screen Examinees
Kil Su Kim, Young Sik Choi, Yo Han Park
Kosin Med J. 2006;21(1):207-217.
  • 212 View
  • 0 Download
PDF
Lifestyle behaviors associated with metabolic syndrome in medical check-up examinee
Cheol Hoon Kim, Byung Chul Yoo, Yong Hwan Lee
Kosin Med J. 2006;21(1):227-234.
  • 235 View
  • 1 Download
PDF
Association Between Polymorphism Exon 1 Variant (G-^A) at the Locus of the Scavenger Receptor Class B Type-I Gene and Metabolic Syndrome
Chun Ho Park, Byung Chul Yoo, Yong Hwan Lee
Kosin Med J. 2006;21(1):275-283.
  • 133 View
  • 0 Download
PDF
Sexual Differences of High Sensitivity C-reactive Protein in Metabolic Syndrome Patients
Sang Ho Lee, Mi Hong Jeong, Soon Rye Lee, Byung Chul Yoo, Yong Hwan Lee
Kosin Med J. 2006;21(2):8-14.
  • 216 View
  • 0 Download
PDF

KMJ : Kosin Medical Journal