- The solid predominant subtype as an independent risk factor for recurrence in patients with pathologic stage I lung adenocarcinoma
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Chul Ho Lee, Yun-Ho Jeon
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Kosin Med J. 2023;38(2):117-125. Published online June 8, 2023
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DOI: https://doi.org/10.7180/kmj.23.103
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 Abstract
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- Background
Increasingly many patients have been diagnosed with stage I adenocarcinoma due to the use of low-dose chest computed tomography for lung cancer screening. Therefore, this study aimed to analyze tumor recurrence based on the predominant subtype in patients with stage I lung adenocarcinoma who underwent lobectomy.
Methods
We retrospectively analyzed 114 patients who underwent lobectomy for pathologic stage I lung adenocarcinoma from June 2001 to July 2019.
Results
In univariate analyses, significant factors were current smoking at the time of surgery (p=0.029), pathologic tumor size (p=0.006), central tumor location (p=0.003), maximum standardized uptake value on positron emission tomography-computed tomography (p=0.001), and the solid predominant subtype (p=0.012). In the multivariate analysis, only the solid predominant subtype (hazard ratio, 9.702; 95% confidence interval, 1.179–79.874; p=0.035) was an independent risk factor.
Conclusions
If the solid subtype is predominant in pathologic findings, adjuvant chemotherapy after standard surgical resection may be considered to help reduce the risk of tumor recurrence and increase survival.
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KOSIN UNIVERSITY COLLEGE OF MEDICINE
