KOSIN UNIVERSITY COLLEGE OF MEDICINE
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- Application of Raman spectroscopy in breast cancer surgery
- Yikeun Kim, Sung Ui Jung, Jinhyuk Choi
- Kosin Med J. 2023;38(3):176-183. Published online September 14, 2023
- DOI: https://doi.org/10.7180/kmj.23.129
- 1,341 View
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- The incidence of breast cancer is increasing worldwide. As cancer screening has become more widespread, the rate of early breast cancer detection has increased and treatment methods have changed. Partial mastectomy is performed more often than total mastectomy for the surgical treatment of early breast cancer, and sentinel lymph node biopsy plays an important role. A high level of accuracy is necessary for the intraoperative examination of surgical margins and sentinel lymph nodes to identify malignancies. Therefore, several examination techniques, including Raman spectroscopy, that replace or supplement the currently used frozen-section methods are being studied. Raman spectroscopy has the ability to diagnose cancer in normal tissue by providing in real time a chemical fingerprint that can be used to differentiate between cells and tissues. Numerous studies have investigated the utilization of Raman spectroscopy to identify cancer in the margins of resected tissues and sentinel lymph nodes during breast cancer surgery, showing the potential of this technique for clinical applications. This article introduces and reviews the research on Raman spectroscopy for breast cancer surgery.
- Analysis of factors related systemic recurrence after breast conserving surgery in stage I breast cancer
- Yoon-Seok Kim, Dong-Won Ryu, Chung-Han Lee
- Kosin Med J. 2018;33(3):289-296. Published online December 31, 2018
- DOI: https://doi.org/10.7180/kmj.2018.33.3.289
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Objectives In these days, patients with stage I breast cancer have increased by regular health examination and diagnostic tool development. The aim of this retrospective study is to identify systemic recurrence related factors after breast conserving surgery (BCS) for stage I breast cancer.
Methods In this study, we analyzed the correlation between systemic recurrence and pathologic factors. We reviewed 223 patients who underwent BCS for stage I breast cancer. Postoperative pathologic factors, recurrent rates and sites were studied. In addition, preoperative patients'data were also collected. Statistical analysis was done by using PASW 16.0 (SPSS Inc., Chicago, IL, USA).
Results Systemic recurrence was found in 16 patients (7.17%) within 5 years after primary surgery. 5 patients had lymphatic invasion and 6 patients had vascular invasion. Lymphatic and vascular invasion had statistical correlation with systemic recurrence (
P = 0.004,P = 0.001).Conclusions In this retrospective study, we can conclude that vascular invasion and lymphatic invasion are related systemic recurrence after BCS for stage I patients. Further studies with large cohort will be required to fully understand the risk factors of systemic recurrence for stage I breast cancer patients.
- Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
- Sun-yong Hwang, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Juhyun Seo
- Kosin Med J. 2015;30(2):103-107. Published online January 20, 2015
- DOI: https://doi.org/10.7180/kmj.2015.30.2.103
- 1,108 View
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- 2 Citations
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Abstract Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer. Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known as anticancer material especially breast cancer. Breast cancer is disease taking high occurrence level among feminine diseases. DHA has anticancer effects on breast cancer cell, representatively inducing apoptosis, inhibiting proliferation or metastasis. Main effect of DHA on breast cancer cell is apoptosis inducing, which has mechanism that treated DHA causes lipid peroxidation increasing reactive oxygen species (ROS) level and it activates caspase 8 and caspase 9 so activated caspase occurs apoptosis. Cell lines of breast cancer are MDA-MB-231, MCF-7, SK-BR-3, T47D and ZR75. Especially this article uses the MCF-7 cell line at experiment of anti-proliferation by DHA, the MDA-MB-231 cell line at experiment of anti-metastasis by DHA, because that cell line has specialized metastasis activity. Therefore, this paper discusses the effects of natural material DHA as drug of breast cancer.
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- The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer
Rui Guo, Yu Chen, Heather Borgard, Mayumi Jijiwa, Masaki Nasu, Min He, Youping Deng
Molecules.2020; 25(20): 4864. CrossRef - Plasma metabolites as possible biomarkers for diagnosis of breast cancer
Jiwon Park, Yumi Shin, Tae Hyun Kim, Dong-Hyun Kim, Anbok Lee, Mohana Krishna Reddy Mudiam
PLOS ONE.2019; 14(12): e0225129. CrossRef
- The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer
- Peritoneal and gastric metastasis from invasive lobular breast carcinoma: a case report
- Yoon Seok Kim, Eun Ae Jae, Dong Won Ryu, Chung Han Lee
- Kosin Med J. 2015;30(1):87-92. Published online January 20, 2015
- DOI: https://doi.org/10.7180/kmj.2015.30.1.87
- 1,160 View
- 3 Download
- 1 Citations
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Abstract Peritoneal and gastrointestinal metastasis from breast cancer is very rare. We report here a rare case of metastatic peritoneal and gastric cancer from breast lobular carcinoma after modified radical mastectomy. A 65-year old woman presented with anorexia, nausea, vomiting and dyspepsia for several weeks at 44 months after surgery. Radiologic study showed peritoneal metastasis, and surgical histopathology reported peritoneal and omental metastatic carcinoma. Esophagogastroduodenoscopic (EGD) biopsy also confirmed metastatic carcinoma originated from breast primary.
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Citations
Citations to this article as recorded by- Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
Sun-yong Hwang, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Juhyun Seo
Kosin Medical Journal.2015; 30(2): 103. CrossRef
- Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
- Imaging Findings of Breast Cancer Assessed as BI-RADS Category 3 and 4a
- Mi Hee Jung
- Kosin Med J. 2008;23(4):27-31. Published online December 31, 2008
- 249 View
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