Peritoneal and gastric metastasis from invasive lobular breast carcinoma: a case report

Article information

Kosin Med J. 2015;30(1):87-92
Publication date (electronic) : 2015 January 20
doi : https://doi.org/10.7180/kmj.2015.30.1.87
1Department of Surgery, College of Medicine, Kosin University, Busan, Korea
2Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea
Corresponding Author:Chung Han Lee Department of Surgery, Kosin University College of Medicine, 262, Gamcheon-ro, Seo-gu, Busan 602-702, Korea TEL: +82-51-990-6462 FAX: +82-51-246-6093 E-mail: mammomaster@naver.com
Received 2013 September 12; 2014 January 15; Accepted 2014 February 03.

Abstract

Abstract

Peritoneal and gastrointestinal metastasis from breast cancer is very rare. We report here a rare case of metastatic peritoneal and gastric cancer from breast lobular carcinoma after modified radical mastectomy. A 65-year old woman presented with anorexia, nausea, vomiting and dyspepsia for several weeks at 44 months after surgery. Radiologic study showed peritoneal metastasis, and surgical histopathology reported peritoneal and omental metastatic carcinoma. Esophagogastroduodenoscopic (EGD) biopsy also confirmed metastatic carcinoma originated from breast primary.

Fig. 1.

PET scan showed glucose hypermetabolism of abdominal cavity consistent with cancer peritonei. PET: positive emission tomography.

Fig. 2.

(A, B) Abdominal CT scans showed ascites, peritoneal thickening, omental smudge and cakes consistent with cancer peritonei. (C) Hydronephrotic change at the right kidney also presented. CT: computed tomography.

Fig. 3.

(A) After 9 cycles of chemotherapy, abdominal CT scans showed improving process with decreased ascites. (B) There are also hydronephrosis and hydroureter at the right kidney and ureter. CT: computed tomography.

Fig. 4.

EGD showed (A) esophageal candidiasis at the esophagus and (B) metastatic gastric carcinoma from breast at the body of stomach. EGD: esophagogastroduodenoscopy.

References

1. Ciulla A, Castronovo G, Tomasello G, Maiorana AM, Russo L, Daniele E, et al. Gastric metastases originating from occult breast lobular carcinoma: diagnostic and therapeutic problems. World J Surg 2008;6:78.
2. Ayantunde AA, Agrawal A, Parsons SL, Welch NT. Esophagogastric cancers secondary to a breast primary tumor do not require resection. World J Surg 2007;31:1597–601.
3. Choi JE, Park SY, Jeon MH, Kang SH, Lee SJ, Bae YK, et al. Solitary small bowel metastasis from breast cancer. J Breast Cancer 2011;14:69–71.
4. Tremblay F, Jamison B, Meterissian S. Breast cancer masquerading as a primary gastric carcinoma. J Gastrointest Surg 2002;6:614–6.
5. Nazareno J, Taves D, Preiksaitis HG. Metastatic breast cancer to the gastrointestinal tract: a case series and review of the literature. World J Gastroenterol 2006;12:6219–24.
6. Pectasides D, Psyrri A, Pliarchopoulou K, Floros T, Papaxoinis G, Skondra M, et al. Gastric metastases originating from breast cancer: report of 8 cases and review of the literature. Anticancer Res 2009;29:4759–64.
7. Jones GE, Strauss DC, Forshaw MJ, Deere H, Mahedeva U, Mason RC. Breast cancer metastasis to the stomach may mimic primary gastric cancer: report of two cases and review of literature. World J Surg Oncol 2007;5:75.
8. Ambroggi M, Stroppa EM, Mordenti P, Biasini C, Zangrandi A, Michieletti E, et al. Metastatic breast cancer to the gastrointestinal tract: report of five cases and review of the literature. Int J Breast Cancer 2012;2012:439023.
9. Tuthill M, Pell R, Guiliani R, Lim A, Gudi M, Contractor KB, et al. Peritoneal disease in breast cancer: a specific entity with an extremely poor prognosis. Eur J Cancer 2009;45:2146–9.
10. van Velthuysen ML, Taal BC, van der Hoeven JJ, Peterse JL. Expression of oestrogen receptor and loss of E-cadherin are diagnostic for gastric metastasis of breast carcinoma. Histopathology 2005;46:153–7.

Article information Continued

Fig. 1.

PET scan showed glucose hypermetabolism of abdominal cavity consistent with cancer peritonei. PET: positive emission tomography.

Fig. 2.

(A, B) Abdominal CT scans showed ascites, peritoneal thickening, omental smudge and cakes consistent with cancer peritonei. (C) Hydronephrotic change at the right kidney also presented. CT: computed tomography.

Fig. 3.

(A) After 9 cycles of chemotherapy, abdominal CT scans showed improving process with decreased ascites. (B) There are also hydronephrosis and hydroureter at the right kidney and ureter. CT: computed tomography.

Fig. 4.

EGD showed (A) esophageal candidiasis at the esophagus and (B) metastatic gastric carcinoma from breast at the body of stomach. EGD: esophagogastroduodenoscopy.