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Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells

Article information

Kosin Med J. 2015;30(2):103-107
Publication date (electronic) : 2015 January 20
doi : https://doi.org/10.7180/kmj.2015.30.2.103
Sun-yong Hwang1, Tae-Hee Kim2,, Hae-Hyeog Lee2, Heung Yeol Kim3, Juhyun Seo4
1Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, Republic of Korea
2Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Bucheon, Republic of Korea
3Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Republic of Korea
4Department of Life Science and Biotechnology, Soonchunhyang University College of Natural Sciences, Asan, Republic of Korea
Corresponding Author: Tae-Hee Kim, MD, PhD, Department of Obstetrics and Gynecology, SoonchunhyangUniversity Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14584, Korea TEL: +82-32-621-5380, Fax: +82-2-6008-6874 E-mail: heeobgy@schmc.ac.kr; heeobgy@naver.com
Received 2015 September 15; 2015 September 15; Accepted 2015 September 16.

Abstract

Abstract

Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer. Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known as anticancer material especially breast cancer. Breast cancer is disease taking high occurrence level among feminine diseases. DHA has anticancer effects on breast cancer cell, representatively inducing apoptosis, inhibiting proliferation or metastasis. Main effect of DHA on breast cancer cell is apoptosis inducing, which has mechanism that treated DHA causes lipid peroxidation increasing reactive oxygen species (ROS) level and it activates caspase 8 and caspase 9 so activated caspase occurs apoptosis. Cell lines of breast cancer are MDA-MB-231, MCF-7, SK-BR-3, T47D and ZR75. Especially this article uses the MCF-7 cell line at experiment of anti-proliferation by DHA, the MDA-MB-231 cell line at experiment of anti-metastasis by DHA, because that cell line has specialized metastasis activity. Therefore, this paper discusses the effects of natural material DHA as drug of breast cancer.

Keywords: Apoptosis; breast neoplasms; docosahexaenoic acid; metastasis; proliferation

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