An atypical case of Lemierre syndrome following oropharyngeal infection

Article information

Kosin Med J. 2018;33(1):110-116
Publication date (electronic) : 2018 January 21
doi : https://doi.org/10.7180/kmj.2018.33.1.110
Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospitial, Seoul, Korea
Corresponding Author: Su Jin Jeong, Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospitial, 211 Eonju-ro, Gangnam-gu, Seoul 06273, Korea Tel: +82-2-2019-3304 Fax: +82-2-2019-3304 E-mail: JSJ@yuhs.ac.kr
Received 2015 October 26; 2015 October 26; Accepted 2015 November 18.

Abstract

Lemierre syndrome is characterized by anaerobic bacterial infection in the head and neck and clinical or radiological evidence of internal jugular vein thrombophlebitis. The most common pathogens are Fusobacterium species, particularly Fusobacterium necrophorum. Septic emboli resulting from infected thrombophlebitis of the internal jugular vein leads to metastatic infections involving lung, liver, kidney, bone and central nervous system. The accurate diagnosis and treatment is important because it may be associated with a high mortality rate if untreated. We present a case of 28-year-old man with an atypical history for the diagnosis of Lemierre syndrome, which showed no definite evidence of internal jugular thrombophlebitis.

Fig. 1.

Chest X-ray (Admission day)

Fig. 2.

Computed tomography of neck. It shows diffuse enlargement of both tonsil (A) and reactive lymph nodes in both neck level II, III. (B) There is no definite evidence of internal jugular thrombophlebitis. (C)

Fig. 3.

Chest X-ray and Computed tomography of chest. It shows empyema of left lung (arrow).

References

1. Lemierre A. On certain septicaemias due to anaerobic organisms. The Lancet 1936;227:701–3.
2. Golpe R, Marin B, Alonso M. Lemierre's syndrome (necrobacillosis). Postgrad Med J 1999;75:141–4.
3. Sinave CP, Hardy GJ, Fardy PW. The Lemierre syndrome: suppurative thrombophlebitis of the internal jugular vein secondary to oropharyngeal infection. Medicine (Baltimore) 1989;68:85–94.
4. Chirinos JA, Lichtstein DM, Garcia J, Tamariz LJ. The evolution of Lemierre syndrome: report of 2 cases and review of the literature. Medicine (Baltimore) 2002;81:458–65.
5. Syed MI, Baring D, Addidle M, Murray C, Adams C. Lemierre syndrome: two cases and a review. Laryngoscope 2007;117:1605–10.
6. Karkos PD, Asrani S, Karkos CD, Leong SC, Theochari EG, Alexopoulou TD, et al. Lemierre's syndrome: A systematic review. Laryngoscope 2009;119:1552–9.
7. Henry S, DeMaria A Jr., McCabe WR. Bacteremia due to Fusobacterium species. Am J Med 1983;75:225–31.
8. Leugers CM, Clover R. Lemierre syndrome: post-anginal sepsis. J Am Board Fam Pract 1995;8:384–91.
9. Lustig LR, Cusick BC, Cheung SW, Lee KC. Lemierre's syndrome: two cases of postanginal sepsis. Otolaryngology--Head and Neck Surgery 1995;112:767–72.
10. Shakeel M, McCluney N, Li L, Newton JR. Oropharyngeal infection with metastatic hand infection: an uncommon variant of Lemierre's syndrome. J Pak Med Assoc 2010;60:494–6.
11. Williams A, Nagy M, Wingate J, Bailey L, Wax M. Lemierre syndrome: a complication of acute pharyngitis. Int J Pediatr Otorhinolaryngol 1998;45:51–7.
12. Ridgway JM, Parikh DA, Wright R, Holden P, Armstrong W, Camilon F, et al. Lemierre syndrome: a pediatric case series and review of literature. Am J Otolaryngol 2010;31:38–45.
13. Seidenfeld SM, Sutker WL, Luby JP. Fusobacterium necrophorum septicemia following oropharyngeal infection. Jama 1982;248:1348–50.
14. GOLDHAGEN J, ALFORD BA, PREWITT LH, THOMPSON L, HOSTETTER MK. Suppurative thrombophlebitis of the internal jugular vein: report of three cases and review of the pediatric literature. The Pediatric infectious disease journal 1988;7:410–3.
15. Riordan T, Wilson M. .: Lemierre's syndrome: more than a historical curiosa. Postgrad Med J 2004;80:328–34.

Article information Continued

Fig. 1.

Chest X-ray (Admission day)

Fig. 2.

Computed tomography of neck. It shows diffuse enlargement of both tonsil (A) and reactive lymph nodes in both neck level II, III. (B) There is no definite evidence of internal jugular thrombophlebitis. (C)

Fig. 3.

Chest X-ray and Computed tomography of chest. It shows empyema of left lung (arrow).