Meningoencephalitis associated with Parvovirus B19 Infection in an Immunocompetent Patient

Article information

Kosin Med J. 2015;30(2):181-185

Publication date (electronic) : 2015 January 20

doi : https://doi.org/10.7180/kmj.2015.30.2.181

Dae-Seung Lee , Jin-Hyung Lee , So-Young Huh , Min Jeong Kim , Meyung-Kug Kim , Bong-Goo Yoo ^,

Department of Neurology, College of Medicine, Kosin University, Busan, Korea

Corresponding Author: Bong-Goo Yoo, MD, PhD Department of Neurology, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan 49267, Korea TEL: +82-51-990-6364 FAX: +82-51-990-3077 E-mail: ybgne@kosinmed.or.kr

Received 2015 November 30; 2015 November 30; Accepted 2015 November 30.

Abstract

Parvovirus B19 (PVB19) infection is a rare cause of meningoencephalitis. A 53-year-old previously healthy woman presented with fever, headache, and multiple erythema on the both legs. Cerebrospinal fluid study revealed pleocytosis and elevated opening pressure and protein level. Brain MRI showed multiple, asymmetric, hyperintensity in the brain stem, basal ganglia, white matter, and gray matter. Anti-B19 IgM antibody and PCR for PVB19 were positive in serum. Clinician should consider PVB19 infection in any case of acute febrile illness with erythema and meningoencephalitis

Keywords: Meningoencephalitis; MRI; Parvovirus B19

Fig. 1.

Axial FLAIR images show multiple, diffuse, asymmetric hyperintensities involving pons, midbrain, temporal lobe, bilateral thalami, basal ganglia, deep white matter, and temporal and occipital cortex.

Fig. 2.

Follow-up FLAIR images 6 months later demonstrate normal without any residual lesions.

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Fig. 1.

Axial FLAIR images show multiple, diffuse, asymmetric hyperintensities involving pons, midbrain, temporal lobe, bilateral thalami, basal ganglia, deep white matter, and temporal and occipital cortex.

Fig. 2.

Follow-up FLAIR images 6 months later demonstrate normal without any residual lesions.