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Review Article
An overview of the pathogenic mechanisms of autoimmune thyroid disorders
Keun Yong Park
Kosin Medical Journal 2014;29(2):93-98.
DOI: https://doi.org/10.7180/kmj.2014.29.2.93
Published online: December 18, 2014

1Department of Internal Medicine, College of Medicine, Konyang University, Daejeon, Korea

Corresponding Author : Keun Yong Park, Department of Internal Medicine, College of Medicine, Kangyang University, 685, Gasuwon-dong, Seo-gu, Daejeon, Korea TEL: +82-42-600-9169 E-mail: kypark5211@naver.com
• Received: July 29, 2014   • Accepted: August 1, 2014

Copyright © 2014 Kosin University School of Medicine Proceedings

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Objectives, recent epidemiologic studies in humans suggest an increased prevalence of thyroiditis associated with the excessive administration of iodine. More than three times of recommended daily intake of iodine was observed among people in North America. These people generally presented higher level of anti-thyroglobulin antibody, anti-thyroperoxidase antibody, serum thyroid-stimulating hormone and exacerbation of lymphocytic infiltration in thyroid, which indicated the overconsumption of iodine could induce hypothyroidism and enhance the autoimmune response. However, the precise mechanism of excessive iodine intake induced autoimmune thyroid disease remains largely unknown.
    Over half a century has elapsed since the 1956 identification of thyroglobulin antibodies and the devising of the first experimental model of autoimmune thyroiditis. Since then an incredible amount of experimental work has led to an ever deeper understanding of the nature of thyroid auto-antigens, the main immune mechanisms responsible for Hashimoto's thyroiditis and graves’ disease, their genetics, and therir environmental risk factor. Yet, in the majority of genetically predisposed people the individual trigger of thyroid autoimmunity remains obscure. Similarly, effective prevention strategies still remain to be established and, hopefully, will be the target of future studies.
  • Keywords: Autoimmune; Pathogenic mechanism; Thyroid disorders
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    • Selective Silencing of Disease-Associated B Lymphocytes from Hashimoto’s Thyroiditis Patients by Chimeric Protein Molecules
      Nikola Ralchev Ralchev, Aleksandar Mishel Markovski, Inna Angelova Yankova, Iliyan Konstantinov Manoylov, Irini Atanas Doytchinova, Nikolina Mihaylova Mihaylova, Alexander Dimitrov Shinkov, Andrey Ivanov Tchorbanov
      International Journal of Molecular Sciences.2022; 23(23): 15083.     CrossRef

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      An overview of the pathogenic mechanisms of autoimmune thyroid disorders
      Kosin Med J. 2014;29(2):93-98.   Published online December 18, 2014
      DOI: https://doi.org/10.7180/kmj.2014.29.2.93
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