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Case Report
A Case of Glomerulonephritis Associated with Klinefelter' Syndrome - Jin Hyuk Cho, Yeoung Sin Sin, Eun Hee Sim, Min Gyu Park, Dong Heo, Hak Rim
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Kosin Medical Journal 2012;27(2):177-180.
DOI: https://doi.org/10.7180/kmj.2012.27.2.177
Published online: December 27, 2012
1Department of Internal Medecine, Dae Dong Hospital, Busan, Korea.
2Department of Nephrology, College of Medicine, Kosin University, Gospel Hospital, Busan, Korea.
- Corresponding Author: Jin Hyuck Cho, Department of internal medecine, Dae Dong Hospital, Myeongnyun-dong, Dongnae-gu, Busan 607-711, Korea. TEL: +82-10-5334-7508, FAX: +82-51-553-7575, happy2639@hanmail.net
• Received: June 14, 2012 • Revised: July 25, 2012 • Accepted: August 5, 2012
Copyright © 2012 Kosin University College of Medicine
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Abstract
- Klinefelter' syndrome is a disorder of sexual differentiation in males, characterized by the presence of two or more X-chromosomes, hypogonadism, and lack of secondary sexual characteristics. The association between Klinefelter' syndrome and glomerulonephritis has been reported, while cases of glomerulonephritis associated with Klinefelter' syndrome are rare. We report the Korean case: a 31-year-old man with Klinefelter' syndrome who developed glomerulonephritis. The patient's urine analysis shows microscopic hematuria and the result of kidney biopsy was minimal change disease. The onset and course of his disease might have been influenced by the sex hormone imbalance.
- 1. Smyth CM, Bremner WJ. Klinefelter syndrome. Arch Intern Med 1998;158:1309–1314.ArticlePubMed
- 2. Geschwind DH, Boone KB, Miller BL, Swerdloff RS. Neurobehavioral phenotype of Klinfelter syndrome. Ment Retard Dev Disabil Res Rev 2000;6:107–116.ArticlePubMed
- 3. Takeuchi Y, Murata Y, Sintani J, Masukawa H, Nakamura R, Oi K, et al. Klinefelter's syndrome accompanied by mixed connective tissue disease and diabetes mellitus. Intern Med 1999;38:875–881.ArticlePubMed
- 4. Aoki N. Klinefelter' syndrome, autoimmunity associated endocrinopathies. Intern Med 1999;38:838–839.ArticlePubMed
- 5. Carlotti AP, Franco PB, Elias LL, Facincani I, Costa EL, Foss N, et al. Glucocorticoid receptors, in vitro steroid sensitivity, and cytokine secretion in idiopathic nephrotic syndrome. Kidney Int 2004;65:403–408.ArticlePubMed
- 6. Friedman A, Waksman Y. Sex hormones and autoimmunity. Isr J Med Sci 1997;33:254–257.PubMed
- 7. Cutolo M, Balleari E, Giusti M, Intra E, Accardo S. Androgen replacement theraphy in male patients with rheumatoid arthritis. Arthritis Rheum 1991;34:1–5.ArticlePubMed
- 8. Zinn AR, Ramos P, Elder FF, Kowal K, Samango-Sprouse C, Ross JL. Androgen receptor CAGn repeat length influences phenotype of 47,XXY (klinefelter) syndrome. J Clin Endocrinol metab 2005;90:5041–5046.ArticlePubMed
- 9. Ichii O, Konno A, Sasaki N, Endoh D, Hashimoto Y, Kon Y. Onset of autoimmune glomerulonephritis derived from the telomeric region of MRL-chromosome 1 is associated with the male sex hormone in mice. Lupus 2009;18:491–500.ArticlePubMed
- 10. Xu Q, Wells CC, Garman JH, Asico L, Escano CS, Maric C. Imbalance in sex hormone levels exacerbates diabetic renal disease. Hypertension 2008;51:1218–1224.ArticlePubMed
- 11. Swerdlow AJ, Higgins CD, Schoemaker MJ, Wright AF, Jacobs PA. United Kingdom Clinical Cytogenetics Group. Mortality in patients with klinefelter syndrome in britain: a cohort study. J Clin Endocrinol Metab 2005;90:6516–6522.ArticlePubMed
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