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Case Report
Metachronous anterior urethral metastasis of prostatic ductal adenocarcinoma
Jeong Hyun Oh1, Taek Sang Kim1, Hyun Yul Rhew1, Bong Kwon Chun2
Kosin Medical Journal 2016;31(1):66-70.
Published online: February 4, 2016

1Deparment of Urology, College of Medicine, Kosin University, Busan, Korea

2Deparment of Pathology, College of Medicine, Kosin University, Busan, Korea

Corresponding Author: Taek Sang Kim, Department of Urology, Kosin University Hospital, 262, Gamcheon-ro, Seo-gu, Busan, 49267, Korea TEL: +82-51-990-6279 FAX: +82-51-990-3994 E-mail:
• Received: March 31, 2015   • Revised: March 31, 2015   • Accepted: June 3, 2015

Copyright © 2016 Kosin University School of Medicine Proceedings

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Prostate cancer is increasing in frequency in Korea. Among them, ductal adenocarcinoma (DCP) has a more aggressive and poor prognosis than acinar adenocarcinoma (ACP), despite its low incidence. Patients usually present with symptoms of lower urinary tract symptoms and hematuria due to increasing tumor mass within the lumen of the prostatic urethra, making diagnosis of DCP by the transrectal prostate biopsy difficult. DCP is often metastasized at the time of diagnosis. DCP is transferable to most other organs but the metastasis to the anterior urethra is rare. There is no doubt that localized DCP requires radical prostatectomy (RP) but the guidelines for adjuvant therapy after RP have not yet been established. Methods of the treatment are confounded by individual differences, and arriving at a consensus is challenging due to insufficient data. We report a case of DCP and urethral metastasis after RP, thus aiding in the determination of treatment guidelines.
Fig. 1.
Prostatic ductal adenocarcinoma Expanding and infiltrating adenocarcinoma is composed of tall columnar cells with abundant amphophilic cytoplasm, pseudostratified arrangement of nuclei and prominent or visible nucleoli.(H-E stain, x12, x40, x400)
Fig. 2A.
The mass in the urethra was showed a papillary shape by cystoscopy.
Fig. 2B.
The papillary urethral mass was removed by the trans urethral resection.
Fig. 3.
Urethral ductal adenocarcinoma This polypoid ductal adenocarcinoma shows large large glands lined by tall pseudostratified columnar cells (H-E stain, x12, x200, x400)
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        Metachronous anterior urethral metastasis of prostatic ductal adenocarcinoma
        Kosin Med J. 2016;31(1):66-70.   Published online February 4, 2016
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