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Original Article
A Comparison of the Recovery Characteristics between Propofol-remifentil and Sevoflurane-remifentail Anesthesia for Total Thyroidectomy
Dong Hee Kang, Jeong Gil Lee, Hyeong Ju Jung, Ju Deok Kim, Soo Bong Yu, Si Jeong Ryu, Gyeong Han Kim, Doo Sik Kim
Kosin Medical Journal 2013;28(2):137-143.
DOI: https://doi.org/10.7180/kmj.2013.28.2.137
Published online: January 19, 2013

Department of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, Busan, Korea

Corresponding author: Doo Sik Kim, Department of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, 34 Amnam-dong, Seo-gu, Busan, 602-702, Korea TEL: +82-51-990-6627 FAX: +82-51-254-2504 E-mail: kds0728@chol.com
• Received: March 12, 2013   • Accepted: June 26, 2013

Copyright © 2013 Kosin University School of Medicine Proceedings

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Objectives
    This study was investigated the recovery characteristics of propofol-remifentanil and sevoflurane-remifentanil anesthesia for total thyroidectomy
  • Methods
    Eighty patients in ASA physical status 1 and 2 scheduled for total thyroidectomy were allocated randomly to either group P (n = 40) or group S (n = 40). Anesthesia was maintained with remifentanil effect site concentration (Ce) 1-3 ng/mL and propofol Ce 2-4 μ g/mL in the group P, and was maintained with remifentanil Ce 1-3 ng/mL and sevoflurane 1.5-2% in the group S. Blood pressure, heart rate, and bispectral (BIS) index were measured during perioperative period. The times from discontinuance of anesthetic agent to eye opening, to extubation, and to stating name were measured. Postoperative complications were evaluated.
  • Objectives
    This study was investigated the recovery characteristics of propofol-remifentanil and sevoflurane-remifentanil anesthesia for total thyroidectomy
  • Methods
    Eighty patients in ASA physical status 1 and 2 scheduled for total thyroidectomy were allocated randomly to either group P (n = 40) or group S (n = 40). Anesthesia was maintained with remifentanil effect site concentration (Ce) 1-3 ng/mL and propofol Ce 2-4 μ g/mL in the group P, and was maintained with remifentanil Ce 1-3 ng/mL and sevoflurane 1.5-2% in the group S. Blood pressure, heart rate, and bispectral (BIS) index were measured during perioperative period. The times from discontinuance of anesthetic agent to eye opening, to extubation, and to stating name were measured. Postoperative complications were evaluated.
  • Results
    There were no significant differences between group P and S on the blood pressure, heart rate, and recovery time. BIS index of group P showed lower than that of group S during operation (P < 0.05). The incidences of side effects were similar in the two groups, though the incidence of nausea was higher in the group S (P < 0.05).
  • Conclusions
    Propofol-remifentanil anesthesia was more advantageous than sevoflurane-remifentanil anesthesia for thyroidectomy in view of side effect incidences.
  • Keywords: Propofol; Remifentanil; Sevoflurane; Total thyroidectomy
Fig. 1.
Perioperative changes of mean arterial pressure (MAP). T0, 2 minutes before the induction; T1, right before the endotracheal intubation; T2, right after the endotracheal intubation; T3, right before the beginning of operation; T4, right after the beginning of operation; T5, right before the extubation; T6, postanesthetic care unit (PACU). Group P, propofol and remifentanil; Group S, sevoflurane and remifentanil. Each data was shown as mean ± SD (between groups: P = 0.465).
kmj-28-137f1.jpg
Fig. 2.
Perioperative changes of heart rate (HR). T0, 2 minutes before the induction; T1, right before the endotracheal intubation; T2, right after the endotracheal intubation; T3, right before the beginning of operation; T4, right after the beginning of operation; T5, right before the extubation; T6, postanesthetic care unit (PACU). Group P, propofol and remifentanil; Group S, sevoflurane and remifentanil. Each data was shown as mean ± SD (between groups: P = 0.691).
kmj-28-137f2.jpg
Fig. 3.
Perioperative change of bispectral (BIS) index. T0, 2 minutes before the induction; T1, right before the endotracheal intubation; T2, right after the endotracheal intubation; T3, right before the beginning of operation; T4, right after the beginning of operation; T5, right before the extubation. Group P, propofol and remifentanil; Group S, sevoflurane and remifentanil. Each data was shown as mean ± SD (between groups: P = 0.001).
kmj-28-137f3.jpg
Table 1.
Characteristics of patients
Group P (n = 40) Group S (n = 40)
Age (yr) 039.2 ± 8.2 041.5 ± 7.5
Sex (M/F) 0005/35 0007/33
Height (cm) 163.7 ± 6.5 161.4 ± 6.7
Weight (kg) 060.6 ± 5.5 057.9 ± 7.2
Duration of anesthesia (min) 143.7 ± 23.5 155.1 ± 19.8

Values are mean ± SD.

Group P, propofol and remifentanil; Group S, sevoflurane and remifentanil. There were no differences between two groups.

Table 2.　Emergence
times from discontinuance of anesthetic drug
Group P (n = 40) Group S (n = 40)
Time to eye opening (min) 11.2 ± 2.7 10.4 ± 1.9
Time to extubation (min) 11.9 ± 2.4 11.1 ± 1.9
Time to stating name (min) 14.1 ± 2.2 14.5 ± 2.4

Each data was shown as mean ± SD.

Group P, propofol and remifentanil; Group S, sevoflurane and remifentanil. There were no differences between two groups.

Table 3.
Emergence complications of postoperative period
Group P Group S
(n = 40) (n = 40)
Coughing 0 (0%) 4 (10%)
Nausea and Vomiting 3 (7.5%) 13 (32.5%)*
Nausea only 3 (7.5%) 10 (25%)*
Nausea with vomiting 0 (0%) 3 (7.5%)
Breath holding 0 (0%) 0 (0%)
Shivering 1 (2.5%) 0 (0%)

Number (%). Group P, propofol and remifentanil; Group S, sevoflurane and remifentanil. *P < 0.05.

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    • Comparison of Postoperative Pain and Nausea and Vomiting between Desflurane and Desflurane-remifentanil Anesthesia for Gynecologic Laparoscopic Surgery
      In-Suk Lee, Yun-Mi Kim
      Korean Journal of Women Health Nursing.2015; 21(1): 1.     CrossRef

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      A Comparison of the Recovery Characteristics between Propofol-remifentil and Sevoflurane-remifentail Anesthesia for Total Thyroidectomy
      Kosin Med J. 2013;28(2):137-143.   Published online January 19, 2013
      DOI: https://doi.org/10.7180/kmj.2013.28.2.137
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