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Case Report
Two Cases of Increased Parasympathetic Nerve System in Irritable Bowel Syndrome with Diarrhea as a Predominant Symptom
Eui Kyu Kang, Jong Soon Choi
Kosin Medical Journal 2013;28(1):49-54.
Published online: January 19, 2013
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Department of Family Medicine, College of Medicine, Kosin University, Busan, Korea

Corresponding author: Jong Soon Choi, Department of Family Medicine, College of Medicine, Kosin University, #34, Amnamdong, Suhgu, Busan 602-030, Korea Tel: +82-51-990-6476, E-mail:
• Received: July 25, 2012   • Accepted: September 28, 2012

Copyright © 2013 Kosin University School of Medicine Proceedings

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • The irritable bowel syndrome(IBS) is a chronic functional gastrointestinal disorder, characterized by abdominal pain, bloating and bowel disturbance. The pathophysiology of IBS is very complicated. Recent studies indicate that the most important mechanisms include visceral hypersensitivity, abnormal gut motility, autonomic nervous system(ANS) dysfunction and disorder of regulation of the brain-gut axis. Patients with IBS frequently present impaired autonomic regulation. Heart rate variability(HRV) is an acknowledged tool for estimating autonomic function. We experienced two cases of increased parasympathetic nervous system by HRV in irritable bowel syndrome with diarrhea as a predominant symptom
Fig. 1.
Five-minute time & frequency domain indices of heart rate variability (case 1)
Fig. 2.
Five-minute time & frequency domain indices of heart rate variability (case 2)
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        Two Cases of Increased Parasympathetic Nerve System in Irritable Bowel Syndrome with Diarrhea as a Predominant Symptom
        Kosin Med J. 2013;28(1):49-54.   Published online January 19, 2013
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