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4 "Papillary thyroid cancer"
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Original articles
Risk factors for central and lateral lymph node metastasis in papillary thyroid carcinoma
Ji Hyun Ahn, Hee Kyung Chang
Kosin Med J. 2022;37(4):311-319.   Published online December 19, 2022
DOI: https://doi.org/10.7180/kmj.22.136
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Abstract PDFPubReader   ePub   
Background
Lymph node metastasis (LNM) is commonly observed in papillary thyroid carcinoma. This study aimed to investigate the risk factors for LNM in patients with papillary thyroid carcinoma.
Methods
The clinicopathological factors of 417 patients were investigated, and differences according to the presence or absence of LNM were evaluated.
Results
LNM was associated with age <55 years, male sex, tumor size >10 mm, multiple and bilateral tumors, tumor involving the lower pole or entire lobe, lymphovascular invasion (LVI), perineural invasion (PNI), and extrathyroidal extension (ETE). Univariable and multivariable analyses showed that age <55 years, male sex, tumor size >10 mm, LVI, and ETE were related to central LNM. Male sex, tumor size >10 mm, and LVI were correlated with lateral LNM (p<0.05). Compared to central LNM, more lymph nodes were involved in metastases and the metastatic tumors were larger in lateral LNM. Extranodal extension (ENE) was more commonly observed in lateral LNM (p<0.001) and was associated with tumor size >10 mm, multifocality, PNI, ETE, and the absence of lymphocytic thyroiditis (p<0.05).
Conclusions
Younger age, male sex, tumor size >10 mm, LVI, and ETE were risk factors for central LNM, while male sex, tumor size >10 mm, and LVI were risk factors for lateral LNM. ENE was more commonly observed in lateral LNM, and tumor size >10 mm, multifocal tumors, PNI, ETE, and tumors unrelated to lymphocytic thyroiditis were risk factors for ENE.

Citations

Citations to this article as recorded by  
  • Alterations in the amino acid profile in patients with papillary thyroid carcinoma with and without Hashimoto’s thyroiditis
    Andrzej Hellmann, Jacek Turyn, Agata Zwara, Justyna Korczynska, Aleksandra Taciak, Adriana Mika
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
Expressions of miRNAs in Papillary Thyroid Carcinoma and Their Associations with the BRAFV600E Mutation and Clinicopathological Features
Song I Yang, Young Sik Choi
Kosin Med J. 2020;35(1):1-14.   Published online June 30, 2020
DOI: https://doi.org/10.7180/kmj.2020.35.1.1
  • 961 View
  • 16 Download
Abstract PDFPubReader   ePub   
Objectives

The microRNAs (miRNAs) are known to be commonly expressed in papillary thyroid carcinoma. The BRAFV600E mutation is the most common genetic mutation in thyroid cancer. The main aim of this study was to determine the possible association between expression of the three miRNAs and that of BRAFV600E mutation and the clinicopathological features in papillary thyroid carcinoma.

Methods

This study was conducted on 51 paraffin-embedded tissues (42 thyroid cancer, 9 benign tumor) obtained from patients undergoing thyroidectomy at the Endocrine Center of OOO University Hospital.

Results

miRNAs expression was significantly high in patients with cervical lymph node metastasis and advanced TNM stage. In addition, miR-146b expression levels were significantly higher in papillary thyroid carcinoma patients with BRAFV600E mutation. The relative quantification (2-ΔΔCt) of miR-146b was also high among the miRNAs. Individually, the AUCs for miRNA-146b was 0.923 (cutoff value −1.97, sensitivity 88.9%, specificity 85.7%).

Conclusions

Especially, expression of miR-146b increased higher in PTC patients with BRAFV600E mutation. These findings showed a role of miR-146b as potential biomarkers in differentiating PTC from benign tumor and as a prognostic indicator of PTCs. Further investigation will need for the roles of miRNAs in the pathogenesis of papillary thyroid carcinomas.

Case report
A Case of Papillary Thyroid Carcinoma Associated with Familial Adenomatous Polyposis
Jong Hyun Paek, Chang Bae Sohn, Eun Young Lee, Jee Suk Lee, Eun Kyung Shin, Eun Ho Park, Jeong Ah Seo, Jae Hong Yang, Jun Young Song, Seon Ja Park, Yo Han Park, Young Sik Choi
Kosin Med J. 2007;22(2):147-150.   Published online December 31, 2007
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Original article
Analyses of Central Neck Lymph Node Metastasis from Papillary Thyroid Cancers
Jae Young Choi
Kosin Med J. 2007;22(2):181-185.   Published online December 31, 2007
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  • 1 Download
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KMJ : Kosin Medical Journal