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- Gut microbiota and nonalcoholic fatty liver disease
- Boyeon Kim, Bukyung Kim
- Kosin Med J. 2023;38(3):169-175. Published online September 22, 2023
- DOI: https://doi.org/10.7180/kmj.23.138
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Abstract
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- The gut microbiota has been reported to exert a significant influence on various physiological responses of hosts. Extensive evidence has recently emerged linking metabolic and cardiovascular disorders to the gut microbiota. Nonalcoholic fatty liver disease (NAFLD) is the most common underlying metabolic disorder, and its prevalence is increasing worldwide. In this study, we aim to review the relationship between the gut microbiota and NAFLD, and explore the potential of the gut microbiota as a novel target for NAFLD treatment.
- Obese Subjects with Non-Alcoholic Fatty Liver Disease Have a Higher Risk of Thyroid Dysfunction
- Minyoung Kim, Soo Kyoung Kim, Jaehoon Jung
- Kosin Med J. 2019;34(2):117-125. Published online December 31, 2019
- DOI: https://doi.org/10.7180/kmj.2019.34.2.117
- 1,440 View
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Objectives The effects of obesity on thyroid function have not been well established. The aim of this study was to investigate the effects of body mass index (BMI) and/or non-alcoholic fatty liver disease (NAFLD) on thyroid function.
Methods A retrospective longitudinal analysis was conducted among subjects who underwent comprehensive health check-ups at least four times between 2008 and 2017. Thyroid function was investigated according to BMI or presence of NAFLD at the end of follow-up. The subjects were divided into four groups: control (n = 216), subjects with obese (n = 94), subjects with NAFLD (n = 48), and subjects with obese + NAFLD (n = 93). Obesity was defined as BMI ≥ 25 kg/m2.
Results During the mean follow-up of 6.8 years (6.8 ± 1.2 years), 42 of the 451 subjects (9.3%) had subclinical hypothyroidism (SCH) but no subjects developed overt hypothyroidism. In multivariate Cox proportional hazard analysis, after adjustment for age, sex, smoking, and baseline thyroid stimulating hormone level, obese subjects with NAFLD had a higher risk of SCH than the control group.
Conclusions The obese subjects with NAFLD had a higher risk for SCH in the future.
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- Hypothyroidism-Induced Nonalcoholic Fatty Liver Disease (HIN): Mechanisms and Emerging Therapeutic Options
Daniela Maria Tanase, Evelina Maria Gosav, Ecaterina Neculae, Claudia Florida Costea, Manuela Ciocoiu, Loredana Liliana Hurjui, Claudia Cristina Tarniceriu, Mariana Floria
International Journal of Molecular Sciences.2020; 21(16): 5927. CrossRef
- Hypothyroidism-Induced Nonalcoholic Fatty Liver Disease (HIN): Mechanisms and Emerging Therapeutic Options
- Relationship with Metabolic Syndrome by Grade of Nonalcoholic Fatty Livers
- Eun Hee Kong
- Kosin Med J. 2009;24(2):103-108. Published online December 31, 2009
- 217 View
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