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23 "Metastasis"
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Case report
Selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4B epithelial ovarian cancer: a case series
Eun Taeg Kim, Seung Yeon Oh, Sun Young Ma, Tae Hwa Lee, Won Gyu Kim
Kosin Med J. 2023;38(4):293-299.   Published online December 20, 2023
DOI: https://doi.org/10.7180/kmj.23.146
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Abstract PDFPubReader   ePub   
Although the efficacy of surgery followed by taxane- and platinum-based systemic chemotherapy has been clearly demonstrated in the standard first-line treatment of epithelial ovarian cancer, the role of radiation therapy for distant lymph node metastasis in patients with epithelial ovarian cancer is not well-established due to a lack of reported studies. We identified four patients who underwent selective adjuvant radiation therapy for neck and para-aortic lymph node lesions after primary debulking surgery between 2020 and 2022, followed by platinum-based chemotherapy for stage 4B high-grade serous ovarian cancer. Through a retrospective review of medical records, we analyzed patient clinicopathologic features, treatment course, and imaging findings. The median age was 49.25 years (range, 46–54 years). All patients had the International Federation of Gynecology and Obstetrics stage 4B disease. Following primary debulking surgery, all patients received weekly paclitaxel-carboplatin chemotherapy and maintenance treatment with poly(ADP-ribose) polymerase (PARP) inhibitors. All patients received selective adjuvant radiation therapy for neck and para-aortic lymph node metastasis before PARP inhibitor maintenance. The median follow-up time was 36.75 months (range, 19–45 months). All patients achieved a complete response. None of the patients experienced disease recurrence or died during the follow-up period. The management of distant lymph node metastasis in patients with epithelial ovarian cancer remains a matter of debate. Selective adjuvant radiation therapy in first-line treatment for ovarian cancer appears to be a feasible approach with maintenance therapy for stage 4B epithelial ovarian cancer.
Original article
Risk factors for central and lateral lymph node metastasis in papillary thyroid carcinoma
Ji Hyun Ahn, Hee Kyung Chang
Kosin Med J. 2022;37(4):311-319.   Published online December 19, 2022
DOI: https://doi.org/10.7180/kmj.22.136
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  • 1 Citations
Abstract PDFPubReader   ePub   
Background
Lymph node metastasis (LNM) is commonly observed in papillary thyroid carcinoma. This study aimed to investigate the risk factors for LNM in patients with papillary thyroid carcinoma.
Methods
The clinicopathological factors of 417 patients were investigated, and differences according to the presence or absence of LNM were evaluated.
Results
LNM was associated with age <55 years, male sex, tumor size >10 mm, multiple and bilateral tumors, tumor involving the lower pole or entire lobe, lymphovascular invasion (LVI), perineural invasion (PNI), and extrathyroidal extension (ETE). Univariable and multivariable analyses showed that age <55 years, male sex, tumor size >10 mm, LVI, and ETE were related to central LNM. Male sex, tumor size >10 mm, and LVI were correlated with lateral LNM (p<0.05). Compared to central LNM, more lymph nodes were involved in metastases and the metastatic tumors were larger in lateral LNM. Extranodal extension (ENE) was more commonly observed in lateral LNM (p<0.001) and was associated with tumor size >10 mm, multifocality, PNI, ETE, and the absence of lymphocytic thyroiditis (p<0.05).
Conclusions
Younger age, male sex, tumor size >10 mm, LVI, and ETE were risk factors for central LNM, while male sex, tumor size >10 mm, and LVI were risk factors for lateral LNM. ENE was more commonly observed in lateral LNM, and tumor size >10 mm, multifocal tumors, PNI, ETE, and tumors unrelated to lymphocytic thyroiditis were risk factors for ENE.

Citations

Citations to this article as recorded by  
  • Alterations in the amino acid profile in patients with papillary thyroid carcinoma with and without Hashimoto’s thyroiditis
    Andrzej Hellmann, Jacek Turyn, Agata Zwara, Justyna Korczynska, Aleksandra Taciak, Adriana Mika
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
Case report
Metastatic ameloblastoma with postoperative accelerated tumor growth treated with carboplatin and paclitaxel: a case report
Joo Un Park, Jae Wan Jung
Kosin Med J. 2022;37(1):83-88.   Published online March 23, 2022
DOI: https://doi.org/10.7180/kmj.21.030
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Abstract PDFPubReader   ePub   
Ameloblastoma is a histologically benign odontogenic epithelial tumor that rarely metastasizes. However, metastasis to the lungs can occur, usually years after the development of the primary tumor. Here, we present the case of a 63-year-old woman with metastatic ameloblastoma in the lungs that developed 12 years after surgery for the primary lesion. As is typical for metastatic ameloblastomas, the tumor was incidentally found on radiography and surgically removed. However, the tumor exhibited accelerated progression with pleural metastasis after surgical removal, which is unusual in metastatic ameloblastoma. The patient was successfully treated with carboplatin/paclitaxel and showed a partial response to tumor progression, implying that this approach can be safely used in the absence of a standard treatment regimen.
Original article
Diagnostic value of magnetic resonance imaging using superparamagnetic iron oxide for axillary node metastasis in patients with breast cancer: a meta-analysis
Ru Da Lee, Jung Gu Park, Dong Won Ryu, Yoon Seok Kim
Kosin Med J. 2018;33(3):297-306.   Published online December 31, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.3.297
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Abstract PDFPubReader   
Objectives

Identification of axillary metastases in breast cancer is important for staging disease and planning treatment, but current techniques are associated with a number of adverse events. This report evaluates the diagnostic accuracy of superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) techniques for identification of axillary metastases in breast cancer patients.

Methods

We performed a meta-analysis of previous studies that compared SPIO enhanced MRI with histological diagnosis after surgery or biopsy. We searched PubMed, Ovid, Springer Link, and Cochrane library to identify studies reporting data for SPIO enhanced MRI for detection of axillary lymph node metastases in breast cancer until December 2013. The following keywords were used: “magnetic resonance imaging AND axilla” and “superparamagnetic iron oxide AND axilla”. Eligible studies were those that compared SPIO enhanced MRI with histological diagnosis. Sensitivity and specificity were calculated for every study; summary receiver operating characteristic and subgroup analyses were done. Study quality and heterogeneity were also assessed.

Results

There were 7 publications that met the criteria for inclusion in our meta-analysis. SROC curve analysis for per patient data showed an overall sensitivity of 0.83 (95% Confidence interval (CI): 0.75–0.89) and overall specificity of 0.97 (95% CI: 0.94–0.98). Overall weighted area under the curve was 0.9563.

Conclusions

SPIO enhanced MRI showed a trend toward high diagnostic accuracy in detection of lymph node metastases for breast cancer. So, when the breast cancer patients has axillary metastases histologically, SPIO enhanced MRI may be effective diagnostic imaging modality for axillary metastases.

Case report
A Case of needle-tract implantation of hepatocellular carcinoma in the ovary after radiofrequency ablation
Seong Woon Yoon, Jin-Sook Jeong, Su Young Kim, Sung Wook Lee, Seun Ja Park
Kosin Med J. 2017;32(2):251-257.   Published online January 19, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.2.251
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  • 2 Citations
Abstract PDFPubReader   ePub   

Radiofrequency ablation (RFA), a local ablative modality, is gaining acceptance for the treatment of liver malignancies. Despite a relatively low complication rate, tumor seeding resulting from RFA in hepatocellular carcinoma (HCC) treatment can occur. A 44-year-old woman was diagnosed with HCC. Spiral computed tomography (CT) revealed a 2.3 × 2.0-cm mass in the S5 segment, which was treated with RFA on May, 2005. Follow-up imaging, performed at 6-month intervals after RFA, showed complete tumor necrosis. In October 2009, CT revealed a heterogeneous mass, 5.7 cm in diameter, in the right ovary. Since the lesion was limited to the right ovary without evidence of spread, bilateral salpingo-oophorectomy was performed. Histopathology indicated that the metastatic spread from the HCC to the ovary was positive for hepatocyte-specific antigen on immunohistochemistry. The ovary is a rare site for HCC metastasis. Moreover, needle tract implantation of HCC in the ovary is very rare.

Citations

Citations to this article as recorded by  
  • A case of hepatocellular carcinoma with metastasis to the ovary
    Haruka AKAJI (KAJIO), Tomoko KURITA, Ryosuke TAJIRI, Hiroshi HARADA, Taeko UEDA, Kiyoshi YOSHINO, Haruko OKA, Nobuyuki TERADO, Aya NAWATA, Yusuke MATSUURA
    The Journal of the Japanese Society of Clinical Cytology.2023; 62(6): 300.     CrossRef
  • Long-term survival of 11 years with multidisciplinary therapy for hepatocellular carcinoma metastasis to the ovary and peritoneum: a case report
    Satoko Motegi, Takeshi Yokoo, Ryosuke Nozawa, Rie Azumi, Yuzo Kawata, Kohei Ogawa, Toru Setsu, Ken-ichi Mizuno, Koji Nishino, Hajime Umezu, Hirokazu Kawai, Takeshi Suda, Shuji Terai
    Clinical Journal of Gastroenterology.2021; 14(4): 1211.     CrossRef
Review articles
Morphine as a suspect of aiding the propagation of cancer cells
Yusom Shin
Kosin Med J. 2017;32(2):164-169.   Published online January 19, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.2.164
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Abstract PDFPubReader   ePub   

Controlling pain in cancer patients is important for several reasons including patient quality of life (QOL). In moderate-to-severe cancer-pain management, opioid analgesics are indispensable. Among these, morphine is the most representative. Unfortunately, many studies have shown that morphine is potentially associated with cancer growth, recurrence, and metastasis. Specifically, in animal as well as in vivo and in vitro studies, morphine has been demonstrated to have possibly positive effects on cancer progression. However, those effects have not yet been confirmed as entirely harmful, for several reasons: the results of animal and laboratory research have not been subjected to clinical trials; there are as yet no well-designed clinical studies, and indeed, some studies have shown that morphine can have negative, suppression effects on tumor growth. This review paper will present some of the data on the potentially positive relationships between morphine and cancer. It should not be forgotten, though, that such relationships remain controversial, and that pain itself promotes cancer progression.

Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
Sun-yong Hwang, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Juhyun Seo
Kosin Med J. 2015;30(2):103-107.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.2.103
  • 1,070 View
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  • 2 Citations
Abstract PDFPubReader   ePub   
Abstract

Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer. Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known as anticancer material especially breast cancer. Breast cancer is disease taking high occurrence level among feminine diseases. DHA has anticancer effects on breast cancer cell, representatively inducing apoptosis, inhibiting proliferation or metastasis. Main effect of DHA on breast cancer cell is apoptosis inducing, which has mechanism that treated DHA causes lipid peroxidation increasing reactive oxygen species (ROS) level and it activates caspase 8 and caspase 9 so activated caspase occurs apoptosis. Cell lines of breast cancer are MDA-MB-231, MCF-7, SK-BR-3, T47D and ZR75. Especially this article uses the MCF-7 cell line at experiment of anti-proliferation by DHA, the MDA-MB-231 cell line at experiment of anti-metastasis by DHA, because that cell line has specialized metastasis activity. Therefore, this paper discusses the effects of natural material DHA as drug of breast cancer.

Citations

Citations to this article as recorded by  
  • The Function and Mechanism of Lipid Molecules and Their Roles in The Diagnosis and Prognosis of Breast Cancer
    Rui Guo, Yu Chen, Heather Borgard, Mayumi Jijiwa, Masaki Nasu, Min He, Youping Deng
    Molecules.2020; 25(20): 4864.     CrossRef
  • Plasma metabolites as possible biomarkers for diagnosis of breast cancer
    Jiwon Park, Yumi Shin, Tae Hyun Kim, Dong-Hyun Kim, Anbok Lee, Mohana Krishna Reddy Mudiam
    PLOS ONE.2019; 14(12): e0225129.     CrossRef
Case reports
Peritoneal and gastric metastasis from invasive lobular breast carcinoma: a case report
Yoon Seok Kim, Eun Ae Jae, Dong Won Ryu, Chung Han Lee
Kosin Med J. 2015;30(1):87-92.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.1.87
  • 1,111 View
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  • 1 Citations
Abstract PDFPubReader   ePub   
Abstract

Peritoneal and gastrointestinal metastasis from breast cancer is very rare. We report here a rare case of metastatic peritoneal and gastric cancer from breast lobular carcinoma after modified radical mastectomy. A 65-year old woman presented with anorexia, nausea, vomiting and dyspepsia for several weeks at 44 months after surgery. Radiologic study showed peritoneal metastasis, and surgical histopathology reported peritoneal and omental metastatic carcinoma. Esophagogastroduodenoscopic (EGD) biopsy also confirmed metastatic carcinoma originated from breast primary.

Citations

Citations to this article as recorded by  
  • Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
    Sun-yong Hwang, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Juhyun Seo
    Kosin Medical Journal.2015; 30(2): 103.     CrossRef
Simultaneous Laparoscopy-Assisted Resection for Colorectal Cancer and Metastases
Seung Hyun Lee, Joong Jae Yoo, Sung Dal Park, Byung Kwon Ahn, Sung Uhn Baek
Kosin Med J. 2015;30(1):73-79.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.1.73
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Abstract PDFPubReader   ePub   
Abstract

With advancement of minimal invasive surgery, a simultaneous laparoscopy-assisted resection for colorectal cancer and metastasis has become feasible. Hence, we report three cases of simultaneous laparoscopic surgery for colorectal cancer with liver or lung metastasis. In the first case, laparoscopic right hemicolectomy and left lateral segmentectomy of liver was performed for ascending colon cancer and liver metastasis. In the second case, laparoscopic right hemicolectomy and wedge resection of right lower lung was performed for cecal cancer and lung metastasis. In the third case, laparoscopic right hemicolectomy and wedge resection of left lower lung was performed for ascending colon cancer and lung metastasis. In the first two cases, patients quickly returned to normal activity. In the third case, postoperative bleeding was observed, but spontaneously stopped. There was no postoperative mortality. Simultaneous laparoscopic surgery represents a feasible option for colorectal cancer with metastases on the other organs.

Original article
Expression of Cathpsin B in the Papillary Thyroid Microcarcinoma
Jae Hong Yang, Young Sik Choi, Yo Han Park, Woo Mi Kim, Jeong Hun Kim, Young Ok Kim
Kosin Med J. 2009;24(2):153-158.   Published online December 31, 2009
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Review article
Update of Targeted Molecular Therapy in Metastatic Renal Cell Carcinoma
Taek Sang Kim, Hyun Yul Rhew
Kosin Med J. 2009;24(1):110-118.   Published online June 30, 2009
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  • 1 Download
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Original article
Usefulness of Thyroglobulin Measurement in Fine-needle Aspiration Washout for Diagnostic of Lymph Ndoe Metastasis in the patients with Papillary Thyroid Cancer
Kyung Soon Jeong
Kosin Med J. 2009;24(1):131-134.   Published online June 30, 2009
  • 173 View
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Case reports
Gastric Metastasis from Hepatocellular Carcinoma
Sang Ho Lee
Kosin Med J. 2008;23(4):291-293.   Published online December 31, 2008
  • 151 View
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A Case of Metastatic Small Cell Lung Carcinoma to the Thyroid Gland
Lee La Jang, Young Sik Choi, Yo Han Park, Dae Sung Moon, Ja Kyung Kim, Sung Eun Kim, In Soo Choi, Chan Hee Yoo, Sung Jin Nam
Kosin Med J. 2008;23(3):118-121.   Published online September 30, 2008
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Original article
The Expression of Survivin mRNA in Patients with Colorectal Carcinomas to The Liver Metastasis
Jong Soon Choi, Hee Kyung Chang
Kosin Med J. 2008;23(1):26-30.   Published online March 31, 2008
  • 310 View
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KMJ : Kosin Medical Journal