Kosin Medical Journal

Gut microbiota and nonalcoholic fatty liver disease: Boyeon Kim, Bukyung Kim; Kosin Med J. 2023;38(3):169-175. Published online September 22, 2023; DOI: https://doi.org/10.7180/kmj.23.138

1,310 View
37 Download

Abstract PDF PubReader ePub: The gut microbiota has been reported to exert a significant influence on various physiological responses of hosts. Extensive evidence has recently emerged linking metabolic and cardiovascular disorders to the gut microbiota. Nonalcoholic fatty liver disease (NAFLD) is the most common underlying metabolic disorder, and its prevalence is increasing worldwide. In this study, we aim to review the relationship between the gut microbiota and NAFLD, and explore the potential of the gut microbiota as a novel target for NAFLD treatment.

Polycystic liver disease: an overview of clinical manifestations, diagnosis, and treatment: Joonho Jeong, Hyun Joon Park; Kosin Med J. 2023;38(2):75-86. Published online June 28, 2023; DOI: https://doi.org/10.7180/kmj.23.128

2,206 View
78 Download
1 Citations

Polycystic liver disease (PLD) is a hereditary disease characterized by the presence of 20 or more liver cysts. It is classified into three types: isolated autosomal dominant PLD, PLD with autosomal dominant polycystic kidney disease, and PLD with autosomal recessive polycystic kidney disease. Genetic alterations, ciliary dysfunction of the biliary epithelial cells, and aberrant cell signaling pathways are the main factors contributing to the pathophysiology of PLD; however, other complicated mechanisms are also involved. The Gigot and Schnelldorfer classifications are widely used in clinical practice. Most patients with PLD are asymptomatic; however, a few patients with advanced-stage disease may develop symptoms and complications that impair their quality of life and require treatment. The known treatment options for PLD are somatostatin analogues, aspiration with sclerotherapy, fenestration, hepatic resection, and liver transplantation. Although liver transplantation remains the only curative treatment for PLD, medical therapies are gradually being developed with the increasing knowledge of the disease’s pathophysiology. This review focuses on the clinical manifestations and diagnosis of PLD, as well as treatment strategies, to support clinicians regarding the clinical management of the disease.

Citations

Citations to this article as recorded by

Predicting Safe Liver Resection Volume for Major Hepatectomy Using Artificial Intelligence
Chol Min Kang, Hyung June Ku, Hyung Hwan Moon, Seong-Eun Kim, Ji Hoon Jo, Young Il Choi, Dong Hoon Shin
Journal of Clinical Medicine.2024; 13(2): 381. CrossRef

Alcohol-related liver disease and liver transplantation: Musheer Shafqat, Ji Hoon Jo, Hyung Hwan Moon, Young Il Choi, Dong Hoon Shin; Kosin Med J. 2022;37(2):107-118. Published online June 27, 2022; DOI: https://doi.org/10.7180/kmj.22.108

1,736 View
29 Download

Abstract PDF PubReader ePub: Alcohol-related liver disease (ALD) has become the major cause of liver transplantation (LT) in Korea, and is currently the most common cause of LT in Europe and the United States. Although, ALD is one of the most common indications for LT, it is traditionally not considered as an option for patients with ALD due to organ shortages and concerns about relapse. To select patients with terminal liver disease due to ALD for transplants, most LT centers in the United States and European countries require a 6-month sober period before transplantation. However, Korea has a different social and cultural background than Western countries, and most organ transplants are made from living donors, who account for approximately twice as many procedures as deceased donors. Most LT centers in Korea do not require a specific period of sobriety before transplantation in patients with ALD. As per the literature, 8%–20% of patients resume alcohol consumption 1 year after LT, and this proportion increases to 30%–40% at 5 years post-LT, among which 10%–15% of patients resume heavy drinking. According to previous studies, the risk factors for alcohol relapse after LT are as follows: young age, poor familial and social support, family history of alcohol use disorder, previous history of alcohol-related treatment, shorter abstinence before LT, smoking, psychiatric disorders, irregular follow-up, and unemployment. Recognition of the risk factors, early detection of alcohol consumption after LT, and regular follow-up by a multidisciplinary team are important for improving the short- and long-term outcomes of LT patients with ALD.

Hepatic steatosis changes after early gastric cancer surgery: Ki Hyun Kim, Soyoung Ock, Dohyung Lee, Yoonhong Kim, Jihoon Jo, Kyungwon Seo, Kiyoung Yoon, Sukyoung Kwon, Youngsik Choi, Bukyung Kim; Kosin Med J. 2022;37(1):68-74. Published online March 28, 2022; DOI: https://doi.org/10.7180/kmj.22.008

1,487 View
32 Download

Abstract PDF PubReader ePub: Background
Nonalcoholic fatty liver disease dramatically improves after bariatric surgery, primarily due to improvements in hepatic insulin sensitivity. Since the procedure for gastric cancer surgery is very similar to that for bariatric surgery, we investigated changes in fatty liver following gastrectomy for gastric cancer according to the type of surgery.
Methods
We evaluated hepatic steatosis in 212 early gastric cancer patients using Hounsfield units (HUs) on non-contrast computed tomography preoperatively and 6, 12, and 24 months after surgery. We compared the preoperative and postoperative liver-to-spleen HU ratio according to the type of surgery: Billroth I, Billroth II, and total gastrectomy with Roux-en-Y reconstruction.
Results
The initial results (liver/spleen HUs and the liver-to-spleen HU ratio) did not significantly differ according to surgical group. After surgery, only patients who underwent total gastrectomy with Roux-en-Y exhibited significant changes in the liver-to-spleen HU ratio at 6 months. In 26 patients who had higher initial HU levels of the spleen than the liver, the liver-to-spleen HU ratio significantly increased from 0.836 to 1.115 at 6 months, 1.109 at 12 months, and 1.102 at 24 months (P<0.01).
Conclusion
Significant changes in hepatic steatosis were found in even normal patients (with higher liver than spleen HU values) who underwent total gastrectomy with Roux-en-Y. Patients who initially had fatty liver also showed a significant increase in the liver-to-spleen HU ratio. These results suggest that total gastrectomy with Roux-en-Y reconstruction can have a positive effect on the improvement of hepatic steatosis.

Obese Subjects with Non-Alcoholic Fatty Liver Disease Have a Higher Risk of Thyroid Dysfunction: Minyoung Kim, Soo Kyoung Kim, Jaehoon Jung; Kosin Med J. 2019;34(2):117-125. Published online December 31, 2019; DOI: https://doi.org/10.7180/kmj.2019.34.2.117

1,444 View
5 Download
1 Citations

Abstract PDF PubReader ePub

Objectives

The effects of obesity on thyroid function have not been well established. The aim of this study was to investigate the effects of body mass index (BMI) and/or non-alcoholic fatty liver disease (NAFLD) on thyroid function.

Methods

A retrospective longitudinal analysis was conducted among subjects who underwent comprehensive health check-ups at least four times between 2008 and 2017. Thyroid function was investigated according to BMI or presence of NAFLD at the end of follow-up. The subjects were divided into four groups: control (n = 216), subjects with obese (n = 94), subjects with NAFLD (n = 48), and subjects with obese + NAFLD (n = 93). Obesity was defined as BMI ≥ 25 kg/m².

Results

During the mean follow-up of 6.8 years (6.8 ± 1.2 years), 42 of the 451 subjects (9.3%) had subclinical hypothyroidism (SCH) but no subjects developed overt hypothyroidism. In multivariate Cox proportional hazard analysis, after adjustment for age, sex, smoking, and baseline thyroid stimulating hormone level, obese subjects with NAFLD had a higher risk of SCH than the control group.

Conclusions

The obese subjects with NAFLD had a higher risk for SCH in the future.

Citations

Citations to this article as recorded by

Hypothyroidism-Induced Nonalcoholic Fatty Liver Disease (HIN): Mechanisms and Emerging Therapeutic Options
Daniela Maria Tanase, Evelina Maria Gosav, Ecaterina Neculae, Claudia Florida Costea, Manuela Ciocoiu, Loredana Liliana Hurjui, Claudia Cristina Tarniceriu, Mariana Floria
International Journal of Molecular Sciences.2020; 21(16): 5927. CrossRef

Relationship with Metabolic Syndrome by Grade of Nonalcoholic Fatty Livers: Eun Hee Kong; Kosin Med J. 2009;24(2):103-108. Published online December 31, 2009

217 View
0 Download

PDF

Hepatitis C Virus Antibodies Among Liver Diseases: Sook Ja Park, June Hyeun Park; The Journal of Kosin Medical College. 1991;7(1):39-46.

285 View
0 Download

PDF

Study of HBV and HCV coinfection according to serologic marker in patients with chronic liver disease: Byung Cheol Yun, Byung Hoon Han, Sang Uk Lee; Kosin Med J. 2004;19(1):94-100.

249 View
1 Download

PDF

The relationship between FattyLiver and Parameters of Metabolic Syndrome in the Non Alcoholic Health Screen Examinees: Kil Su Kim, Young Sik Choi, Yo Han Park; Kosin Med J. 2006;21(1):207-217.

216 View
0 Download

PDF

Search