Skip Navigation
Skip to contents

KMJ : Kosin Medical Journal

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
3 "Glomerulonephritis"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original article
The clinical significance of circulating microRNA-21 in patients with IgA nephropathy
A Young Cho, Ju Hwan Oh, Kwang Young Lee, In O Sun
Kosin Med J. 2022;37(3):242-248.   Published online September 27, 2022
DOI: https://doi.org/10.7180/kmj.22.116
  • 2,095 View
  • 31 Download
Abstract PDFPubReader   ePub   
Background
Urinary microRNA-21 (miR-21) has been reported to correlate with the histologic lesions of IgA nephropathy (IgAN). We investigated whether urinary or circulating miR-21 could serve as a biomarker for detecting the renal progression of IgAN.
Methods
Forty patients with biopsy-proven IgAN were enrolled in this study. Serum and urinary sediment miRs were extracted, and the expression of miR-21 was quantified by real-time quantitative polymerase chain reaction. Renal progression was defined as end-stage renal disease, a sustained doubling of serum creatinine, or a 50% decrease in estimated glomerular filtration rate (eGFR) from baseline.
Results
Six patients experienced renal progression during the follow-up period. The baseline eGFR was lower in the progression group (49±11 mL/min/1.73 m2 vs. 90±23 mL/min/1.73 m2, p<0.05) than in the non-progression group. The level of circulating miR-21 on kidney biopsy was higher in the progression group than in the non-progression group (40.0±0.6 vs. 38.2±1.1 ΔCt value of miR-21, p<0.01), whereas there was no significant difference in urinary miR-21 (38.1±2.1 vs. 37.8±1.4 ΔCt value of miR-21, p=0.687) between the two groups. Receiver operating characteristic curve analysis demonstrated that circulating miR-21 had good discriminative power for diagnosing renal progression of IgAN, with an area under the curve of 0.975.
Conclusions
The level of circulating miR-21 was higher in the progression group than in the non-progression group at the time of kidney biopsy. Therefore, circulating miR-21 could be a surrogate marker of renal progression in patients with IgAN.
Case reports
IgA nephropathy in a patient with ankylosing spondylitis well controlled with etanercept
Do-Hyeong Lee, Geun-Tae Kim, Na-Kyoung Hwang, Eun-Heui Kim
Kosin Med J. 2018;33(1):85-90.   Published online June 30, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.1.85
  • 2,065 View
  • 8 Download
  • 1 Citations
Abstract PDFPubReader   

Ankylosing spondylitis (AS) can involve the eye, gastrointestinal system, cardiopulmonary system, skin, kidneys, and spinal and peripheral joints. It is rarely accompanied by immunoglobulin A (IgA) nephropathy. Although IgA is involved in both AS and IgA nephropathy, the relationship between these diseases remains unclear. We detected hematuria and proteinuria in a 32-year-old male patient with ankylosing spondylitis that remained stable for 4 years through treatment with etanercept, a tumor necrosis factor-α (TNF-α) inhibitor, and diagnosed IgA nephropathy through a renal biopsy. IgA nephropathy seems to be less commonly associated with AS disease activity or specific treatment such as TNF-α inhibitor use.

Citations

Citations to this article as recorded by  
  • IgA Nephropathy—Ankylosing Spondylitis–Associated or Adalimumab-Induced?
    Joana Ricardo Pires, Anabela Tavares Valadão Barcelos
    JCR: Journal of Clinical Rheumatology.2021; 27(8S): S449.     CrossRef
A Case of Glomerulonephritis Associated with Klinefelter' Syndrome
Jin Hyuk Cho, Yeoung Sin Sin, Eun Hee Sim, Min Gyu Park, Dong Heo, Hak Rim
Kosin Med J. 2012;27(2):177-180.   Published online December 27, 2012
DOI: https://doi.org/10.7180/kmj.2012.27.2.177
  • 1,509 View
  • 11 Download
Abstract PDFPubReader   ePub   

Klinefelter' syndrome is a disorder of sexual differentiation in males, characterized by the presence of two or more X-chromosomes, hypogonadism, and lack of secondary sexual characteristics. The association between Klinefelter' syndrome and glomerulonephritis has been reported, while cases of glomerulonephritis associated with Klinefelter' syndrome are rare. We report the Korean case: a 31-year-old man with Klinefelter' syndrome who developed glomerulonephritis. The patient's urine analysis shows microscopic hematuria and the result of kidney biopsy was minimal change disease. The onset and course of his disease might have been influenced by the sex hormone imbalance.


KMJ : Kosin Medical Journal
TOP