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3 "Endometriosis"
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Original article
Observational Study for Adverse Effects and Discontinuation with Long-Term Post-Operative Hormonal Treatment for Endometriosis in Real-World Practice
In Hye Kim, Hyungjoon Yoon, Hyun Joo Lee, Hye Kyung Noh, Jong Kil Joo, Ki Hyung Kim
Kosin Med J. 2021;36(2):116-124.   Published online December 31, 2021
DOI: https://doi.org/10.7180/kmj.2021.36.2.116
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Abstract PDFPubReader   ePub   
Objectives

To evaluate the side effects and causes of discontinuation of either combined oral contraceptives or dienogest (DNG) used to prevent recurrence in patients with surgically confirmed endometriosis.

 Methods

We retrospectively analyzed the medical records of 213 women with endometriosis who had been treated with combined oral contraceptives (ethinyl estradiol 0.02 mg/drospirenone 3 mg [EE/DRSP]) or DNG 2 mg for 12 months or more. The side effects reported by the patients, laboratory parameters, causes of discontinuation of medication, and recurrence rates were evaluated one, two, three, four, and five years after starting medication (Y1, Y2, Y3, Y4, and Y5).

 Results

EE/DRSP were administered to 59 patients, while DNG was administered to 154 patients. The mean durations of postoperative use of EE/DRSP and DNG were 44.5 ± 22.6 months and 23.6 ± 13.5 months, respectively. The prevalence of side effects was 27.1%, 19.0%, 10.0%, 10.5%, and 7.4% in the EE/DRSP group and 29.2%, 15.7%, 14.0%, 23.1%, and 0.0% in the DNG group at Y1, Y2, Y3, Y4, and Y5, respectively. The discontinuation rates were 1.7%, 1.7%, 4.0%, 0.0%, and 7.4% at Y1, Y2, Y3, Y4, and Y5, respectively, in the EE/DRSP group and 10.4%, 3.3%, 4.0%, 3.8%, and 0.0% at the same times in the DNG group. The recurrence rates were less than 4% in both the groups.

 Conclusions

The side effects of commonly prescribed postoperative hormone treatments were relatively mild, and the occurrence of side effects decreased with continuous administration. Further, the long-term use of postoperative hormone treatments is likely to prevent recurrence of endometriosis after surgery.

Review article
Oxidative stress and endometriosis
Yeon Jean Cho, Heung Yeol Kim
Kosin Med J. 2018;33(2):135-140.   Published online December 31, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.2.135
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  • 2 Citations
Abstract PDFPubReader   ePub   

Endometriosis is an estrogen-dependent chronic inflammatory condition that affects women in their reproductive period and is associated with pelvic pain and infertility. Oxidative stress (OS) occurs when reactive oxygen stress (ROS) and anti-oxidants are in imbalance. OS is a potential factor involved in the pathophysiology of endometriosis. Iron-induced ROS may trigger a chain of events resulting in the development and progression of endometriosis. Endogenous ROS are correlated with increased cellular proliferation and ERK1/2 activation in human endometriotic cells. An oxidative environment leads to stimulation of the ERK and PI3K/AKT/mTOR signaling pathways that facilitate endometriotic lesion progression through adhesion, angiogenesis, and proliferation. OS is also known to be involved in epigenetic mechanisms in endometriosis. We summarize the recent knowledge in our understanding of the role of oxidative stress in the pathogenesis of endometriosis.

Citations

Citations to this article as recorded by  
  • Serum trace element levels and activity of enzymes associated with oxidative stress in endometriosis and endometrial cancer
    Miroslava Rabajdová, Ivana Špaková, Lukáš Smolko, Michaela Abrahamovská, Barbora Baranovičová, Anna Birková, Janka Vašková, Mária Mareková
    FEBS Open Bio.2024; 14(1): 148.     CrossRef
  • Zingiber officinale Roscoe (Ginger) as a Complementary Option for Clinical Treatment of Endometriosis: An Experimental Study in Rats
    José Meneses de Morais Filho, João Nogueira Neto, Lyvia Maria Rodrigues de Sousa Gomes, Izabelle Smith Frazão Ramos, Salie Santos Rodrigues Oliveira, George Castro F. Melo, Lucilene Amorim Silva, Ed Carlos Rey Moura, Plínio da Cunha Leal
    Journal of Medicinal Food.2021; 24(4): 342.     CrossRef
Case report
Abdominal Wall Endometriosis Presented with Recurrent Abdominal Pain
박선자
Kosin Med J. 2008;23(1):54-57.   Published online March 31, 2008
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KMJ : Kosin Medical Journal
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