Skip Navigation
Skip to contents

KMJ : Kosin Medical Journal

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
15 "Diagnosis"
Filter
Filter
Article category
Keywords
Publication year
Authors
Review articles
Mucinous carcinoma of the breast: distinctive histopathologic and genetic characteristics
Minjung Jung
Kosin Med J. 2022;37(3):176-186.   Published online August 25, 2022
DOI: https://doi.org/10.7180/kmj.22.022
  • 1,604 View
  • 41 Download
Abstract PDFPubReader   ePub   
Mucinous carcinoma is a rare histologic type of breast cancer that, when classified with favorable histology, can be treated with different therapeutic options. This study reviews the histologic findings of mucinous carcinoma that support or exclude favorable histology and emphasizes the necessity of an appropriate gross examination with radiologic findings for an accurate diagnosis. In addition, unusual findings such as micropapillary arrangements and lobular differentiation in mucinous carcinoma and their implications for prognosis and treatment are reviewed. Mucinous carcinoma involves upregulation of MUC2, a mucus-associated gene common in mucinous carcinoma of the breast as well as various other organs. In mucinous carcinoma, the fraction of genome altered and tumor mutation burden are lower than those of invasive carcinoma of no special type, the most common histology of breast cancer. In addition, the genetic alterations found in mucinous carcinoma are diverse, unlike the pathognomonic genetic alterations observed in other histologic types of breast cancer. These genetic features support the importance of conventional microscopic evaluations for the pathologic differential diagnosis of mucinous carcinoma of the breast in routine practice. A variety of breast lesions, including mucinous cystadenocarcinoma and mucocele-like lesions, as well as mucinous carcinoma from other organs, can mimic mucinous carcinoma of the breast. In order to obtain an accurate pathologic diagnosis, careful evaluation of the overall histopathologic characteristics and ancillary testing are required to provide information on appropriate treatment and prognosis.
The early diagnosis and treatments in multiple sclerosis
So Young Huh
Kosin Med J. 2017;32(2):151-163.   Published online January 19, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.2.151
  • 741 View
  • 4 Download
Abstract PDFPubReader   ePub   

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system that leads to neurological disability. The diagnosis of MS relies on the MRI criteria, which can demonstrate dissemination in space and time. Exclusion of other demyelinating mimics is essential because there are no specific biomarker for MS and MRI criteria are still have imperfect. There is incremental improvements in MS treatment option that have contributed to the delay of disease progression. The early initiation of DMT may ameliorate the neurological disability. In this review, we discusses the new diagnostic MS criteria and summarize the evidences supporting the early treatment in the course of MS.

Case report
Paradoxical response as a cervical lymph node enlargement after termination of anti-tuberculosis treatment in a patient with pulmonary tuberculosis
Hye-Rim Kang, Ho Young Lee, Mi-Yeong Kim, Young Min Lee, Soo Jin Jung, Hyun-Kyung Lee, Si Hyeong Lee, Yunmi Kim
Kosin Med J. 2016;31(1):71-78.   Published online February 4, 2016
DOI: https://doi.org/10.7180/kmj.2016.31.1.71
  • 758 View
  • 2 Download
Abstract PDFPubReader   ePub   
Abstract

A paradoxical response is not uncommon in non-HIV-infected patients, particularly those with extra-pulmonary tuberculosis. It is defined as the radiological and clinical worsening of a previous lesion or the development of new lesion during anti-tuberculosis therapy. The paradoxical response has been attributed to host immunologic reactions, such as a delayed hypersensitivity or a response to mycobacterial antigens. In most reports of paradoxical response, these responses occurred in the same location as a previous lesion. In this patient with pulmonary tuberculosis, cervical lymph node enlargement occurred as a paradoxical response after the completion of anti-tuberculosis treatment. Although the new lesion developed in another location, it could be considered as a paradoxical response based on the negative culture result of acid fast bacilli from the new lesion and drug sensitivity result from initial bronchoalveolar lavage specimen. Therefore we were able to decide on the termination of unnecessary anti-tuberculous treatment. Based on our case, we can conclude that paradoxical response can occur after the termination of anti-tuberculosis therapy even in new site.

Review article
Recent Trends in Chronic Pelvic Pain Diagnosis
Ari Kim, Heung Yeol Kim
Kosin Med J. 2012;27(1):11-16.   Published online June 11, 2012
DOI: https://doi.org/10.7180/kmj.2012.27.1.11
  • 852 View
  • 3 Download
Abstract PDFPubReader   ePub   

Chronic pelvic pain is a common and significant disorder of women. It is estimated to have a prevalence of 3.8% in women. The etiology of chronic pelvic pain in women is poorly understood. Although a specific diagnosis is not found in the majority of cases, some common diagnoses include endometriosis, adhesions, irritable bowel syndrome, and interstitial cystitis. The initial history and physical examination can narrow the diagnostic possibilities, guide any subsequent evaluation, and rule out malignancy or significant systemic disease. If the initial evaluation does not reveal a specific diagnosis, a limited laboratory and ultrasound evaluation can clarify the diagnosis, as well as rule out serious disease and reassure the patient.

Laboratory and imaging studies should be selectively utilized, as should laparoscopy. Conscious laparoscopic pain mapping has been proposed as a way to improve information derived from laparoscopic evaluations.

Original articles
Differential Diagnosis of Fibroadenoma and Phyllodes Tumor - Additional Histopathologic Feature besides Common Diagnostic Criteria
Min Jung Jung
Kosin Med J. 2009;24(2):109-118.   Published online December 31, 2009
  • 186 View
  • 0 Download
PDF
Expression of MAGE in Pleural Fluid for the Differential Diagnosis of Benign and Malignant Pleural Effusion
Chul Ho Oak, Tae Won Jang, Seong Hoon Shin, Man Hong Jung
Kosin Med J. 2008;23(3):17-21.   Published online September 30, 2008
  • 242 View
  • 0 Download
PDF
Case report
A Case of Poorly Differentiated Extraocularsebaceous Carcinoma Mimicking Basal Cell Carcinoma (BCC), Metastatic Skin Cancer
Sang Tae Kim, Hyo Jin Roh, Kee Suck Suh
Kosin Med J. 2008;23(1):47-50.   Published online March 31, 2008
  • 190 View
  • 0 Download
PDF
Original article
Chronic Granulomatous Mastitis
Ryu Dong Won, Jun Chang Wan, Lee Chung Han
Kosin Med J. 2007;22(1):125-128.   Published online June 30, 2007
  • 171 View
  • 0 Download
PDF
Case reports
Malignant Lymphoma with Primary Manifestation in the Ovary - A case report -
In Sun Jun
The Journal of Kosin Medical College. 1985;1(1):73-78.
  • 288 View
  • 0 Download
PDF
A Case of Omphalocele Associated with Meningomyelocele : Diagnosed in the Prenatal Care
Kee Muk Chung, Jae Hoon Chung
The Journal of Kosin Medical College. 1986;2(1):163-168.
  • 222 View
  • 0 Download
PDF
Original articles
Comparative Study on the Specificity and the Sensitivity of Immunoserologic Tests for Trematodes
Mee Sun Ock
The Journal of Kosin Medical College. 1992;8(1):57-62.
  • 186 View
  • 1 Download
PDF
Review article
Molecular Genetic Approaches in the Neuropsychiatric Disorders
JIN SOOK CHEON
The Journal of Kosin Medical College. 1993;9(1):105-127.
  • 270 View
  • 0 Download
PDF
Original articles
ANALYSIS OF REFERRAL CONTENTS IN OUTPATIENT DEPARTMENT OF FAMILY MEDICINE
Eun Hee Kong, Hyeong Soo Cha
Kosin Med J. 1999;14(1-2):81-89.
  • 239 View
  • 0 Download
PDF
Usefulness of Ultrasonic Evaluation in Rotator Cuff Tears
Jeong Ho Park, Won Kwon Choo
Kosin Med J. 2002;17(1):114-121.
  • 219 View
  • 0 Download
PDF

KMJ : Kosin Medical Journal