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KMJ : Kosin Medical Journal



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Ethical issues in clinical research and publication
Hyoung Shin Lee
Kosin Med J. 2022;37(4):278-282.   Published online December 15, 2022
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Clinical research including human participants should be based on truth, demonstrate scientific integrity, and follow ethical standards and guidelines to protect study participants. The publication of clinical research should be transparent and adhere to strict criteria for authorship. A thorough understanding and knowledge of ethical issues will limit investigator misconduct in clinical research and publication. In this article, basic ethical issues in clinical research and publication are reviewed and summarized based on recent guidelines.
How to conduct well-designed clinical research
Da Jung Kim, Song Yi Kil, Jongwon Son, Ho Sup Lee
Kosin Med J. 2022;37(3):187-191.   Published online September 27, 2022
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Clinicians and healthcare decision-makers conduct their clinical practice based on the results of clinical trials. However, some health problems remain unresolved; in such cases, further research is required. To ensure reliable research results, it is important to understand the study design and conduct well-designed clinical trials. Many study designs can be chosen within the two broad categories of observational and interventional. Clinical studies have a variety of designs, including case series, case-control, cross-sectional, and prospective and retrospective cohort studies. Well-designed clinical studies can clarify important differences between treatment options and provide data on long-term drug efficacy and safety. Interpreting the results of clinical trials can be difficult because weaknesses in research design, data collection methods, analytic methods, and reporting can compromise their value and usefulness. However, although randomized controlled trials are limited owing to ethical and practical issues, they are optimal for investigating the effects of therapy and establishing causality. Here we present an overview of different clinical research designs and review their advantages and limitations.


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KMJ : Kosin Medical Journal