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5 "Adolescent"
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Review article
Safety issues regarding melatonin use in child and adolescent patients with sleep problems
Eunsoo Moon, Jung Hyun Lee
Kosin Med J. 2022;37(4):264-270.   Published online December 23, 2022
DOI: https://doi.org/10.7180/kmj.22.142
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Abstract PDFPubReader   ePub   
Several studies have reported that melatonin may be effective in treating sleep problems in children and adolescents. However, evidence regarding the safety of melatonin use in children and adolescents in their growth and developmental stages is warranted. Therefore, we aimed to summarize the literature on the safety of melatonin use in children and adolescents with insomnia and sleep disturbances. According to existing evidence, there are no serious adverse effects of long-term melatonin use in children and adolescents. The common adverse effects reported in long-term studies are fatigue, somnolence, and mood swings. In addition, there is no evidence that long-term use of melatonin inhibits the natural secretion of melatonin. It is necessary to monitor potential drug interactions with medications such as inhibitors and enhancers of cytochrome P450 1A2 (CYP1A2). Furthermore, low CYP1A2 expression in young children requires proper dose adjustment. Although sufficient experience of melatonin use in children and adolescents has yet to be attained, accumulating evidence suggests that the use of melatonin in children and adolescents with sleep problems might be effective and tolerable. Considering the abuse or overdose risk of hypnotics or benzodiazepines, melatonin supplements may be a good therapeutic alternative. Future studies on the long-term safety of melatonin for physiological and mental function in children and adolescents are required to establish certainty about melatonin use in children and adolescents.
Original article
Growth Assessment of Children and Adolescents Complaining of Short Stature
Jung Hyun Lee
Kosin Med J. 2008;23(3):42-48.   Published online September 30, 2008
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Case report
A Case Report of Slipped Capital Femoral Epiphysis Associated with Hypothyroidism and Hypogonadism
Jae Do Kim, Jae Chang Lee, Jeong Ho Park
The Journal of Kosin Medical College. 1991;7(1):87-94.
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Original articles
The relationship between adolescents' permissiveness on moral transgressions and mental health
Young Kum Yoo, Geon-Ho Bahn, Sang Yoon Kim
The Journal of Kosin Medical College. 1996;11(1-2):85-94.
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Self-Concept and Related factors of the Cerebral Palsied Adolescents
Myung Hwa Lee, Hee Sook Hong
Kosin Med J. 2002;17(1):122-136.
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KMJ : Kosin Medical Journal