Skip Navigation
Skip to contents

KMJ : Kosin Medical Journal

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
43 "Young Sik Choi"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original articles
Immediate Changes of Glucose Metabolism After Gastretomy for Early Gastric Cancer in Patients with Type 2 Diabetes
Ki Hyun Kim, Yoon Hong Kim, Kyung Won Seo, Ki Young Yoon, Yeon Myeong Shin, Young Sik Choi, Bu Kyung Kim
Kosin Med J. 2021;36(1):25-33.   Published online June 30, 2021
DOI: https://doi.org/10.7180/kmj.2021.36.1.25
  • 2,019 View
  • 13 Download
  • 1 Citations
Abstract PDFPubReader   ePub   
Objectives

It is well known that type 2 diabetes (T2DM) is dramatically improved after bariatric surgery, although the mechanisms have not been clearly identified. The skill required for gastric surgery for gastric cancer is very similar to that needed in bariatric surgery. In this study, we evaluated the immediate improvement of T2DM after gastrectomy for gastric cancer.

Methods

A total of nine patients who were diagnosed with early gastric cancer (EGC) and already had T2DM underwent a 75 g oral glucose tolerance test (OGTT) before surgery and within two weeks after gastrectomy. Glucose, insulin, and c-peptide were measured before, and 30 and 60 minutes after ingesting 75 g of glucose. From these trials, we calculated the HOMA-IR, insulinogenic index, Matsuda index, and area under the curve (AUC).

Results

The mean age of participants was 57.23 ± 11.08 years and eight of them were men. HOMA-IR (4.2 vs. 2.3, P = 0.012) levels were decreased after surgery. There were no significant differences of insulinogenic index, fasting blood sugar before and after surgery. The Matsuda index (3.3 vs. 8.3, P = 0.002) was significantly increased and AUC (512.9 vs. 388.7 mg-hr/dL, P > 0.001) upon 75 g OGTT was significantly decreased after surgery.

Conclusions

Insulin sensitivity was immediately improved after gastrectomy for early gastric cancer in patients with T2DM.

Citations

Citations to this article as recorded by  
  • Remote health monitoring services in nursing homes
    Jiwon Kim, Hyunsoo Kim, Sungil Im, Youngin Park, Hae-Young Lee, Sookyung Kwon, Youngsik Choi, Linda Sohn, Chulho Oak
    Kosin Medical Journal.2023; 38(1): 21.     CrossRef
Expressions of miRNAs in Papillary Thyroid Carcinoma and Their Associations with the BRAFV600E Mutation and Clinicopathological Features
Song I Yang, Young Sik Choi
Kosin Med J. 2020;35(1):1-14.   Published online June 30, 2020
DOI: https://doi.org/10.7180/kmj.2020.35.1.1
  • 1,716 View
  • 19 Download
  • 1 Citations
Abstract PDFPubReader   ePub   
Objectives

The microRNAs (miRNAs) are known to be commonly expressed in papillary thyroid carcinoma. The BRAFV600E mutation is the most common genetic mutation in thyroid cancer. The main aim of this study was to determine the possible association between expression of the three miRNAs and that of BRAFV600E mutation and the clinicopathological features in papillary thyroid carcinoma.

Methods

This study was conducted on 51 paraffin-embedded tissues (42 thyroid cancer, 9 benign tumor) obtained from patients undergoing thyroidectomy at the Endocrine Center of OOO University Hospital.

Results

miRNAs expression was significantly high in patients with cervical lymph node metastasis and advanced TNM stage. In addition, miR-146b expression levels were significantly higher in papillary thyroid carcinoma patients with BRAFV600E mutation. The relative quantification (2-ΔΔCt) of miR-146b was also high among the miRNAs. Individually, the AUCs for miRNA-146b was 0.923 (cutoff value −1.97, sensitivity 88.9%, specificity 85.7%).

Conclusions

Especially, expression of miR-146b increased higher in PTC patients with BRAFV600E mutation. These findings showed a role of miR-146b as potential biomarkers in differentiating PTC from benign tumor and as a prognostic indicator of PTCs. Further investigation will need for the roles of miRNAs in the pathogenesis of papillary thyroid carcinomas.

Citations

Citations to this article as recorded by  
  • Cyto-Histological Profile of MicroRNAs as Diagnostic Biomarkers in Differentiated Thyroid Carcinomas
    Maria de Lurdes Matos, Mafalda Pinto, Marta Alves, Sule Canberk, Ana Gonçalves, Maria João Bugalho, Ana Luísa Papoila, Paula Soares
    Genes.2024; 15(3): 389.     CrossRef
Iodine nutritional status and awareness of iodine deficiency among adults, including pregnant women, in Tuguegarao, Philippines
Young Sik Choi, Kwang-Hyuk Seok, Jong Jin Lee, Gina Jieun Hong, Pablo M. Afidchao, Bu Kyung Kim, Jee-Yeong Jeong
Kosin Med J. 2018;33(1):64-74.   Published online January 21, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.1.64
  • 1,735 View
  • 7 Download
Abstract PDFPubReader   
Objectives

Iodine deficiency causes multiple health problems. Previously we reported that 96% of high school students in Tuguegarao, Philippines had adequate iodine levels. However, iodine deficiency-associated problems remain among adults in the Philippines. Therefore, we evaluated iodine nutritional status and goiter prevalence among adults, including pregnant women, in Tuguegarao, Philippines.

Methods

A total of 245 adults, including 31 pregnant women, provided samples for urinary iodine analysis, and all pregnant women completed a questionnaire about iodine deficiency.

Results

The median urinary iodine level was 164.0 ± 138.4 g/L; 38.4% of the participants were iodine deficient, according to the International Council for Control of Iodine Deficiency Disorders (ICCIDD) criteria. No severe iodine deficiency was observed. Among the 31 pregnant women, 24 (77.5%) fell into the iodine deficient category defined by a stricter World Health Organization (WHO) guideline, in which iodine deficiency is considered when urinary iodine levels are below 150 g/L. Almost half (42%) of the pregnant women were unaware of the harmful effects of iodine deficiency on the human body and their fetus.

Conclusions

Although iodine nutritional status in the Philippines has improved, iodine deficiency still exists among adults, especially among pregnant women. Therefore, our study strongly suggests that a better strategy should be established to monitor iodine nutritional status among adults continually, and to focus on populations susceptible to iodine deficiency, including pregnant women and women of reproductive age, to achieve the total elimination of iodine deficiency.

Diagnostic value of BRAFV600E mutation analysis in fine needle aspiration for evaluation of thyroid nodules
Hae Won Lee, So Young Ock, Bu Kyoung Kim, Su Kyoung Kwon, Young Sik Choi, Jeong Hoon Kim, Sang Bong Jung
Kosin Med J. 2018;33(1):1-11.   Published online January 21, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.1.1
  • 1,356 View
  • 8 Download
Abstract PDFPubReader   
Objectives

Ultrasound-guided fine-needle aspiration (FNA) is routinely used in the evaluation of thyroid nodules. However, it has several pitfalls, as has been noted in nondiagnostic and indeterminate cases. This study aims to investigate the value of BRAFV600E mutation co-testing in FNA cytology.

Method

A total of 310 patients underwent BRAFV600E mutation co-testing in FNA cytology on thyroid nodules between June 2013 and June 2014. Of the 310 patients, 69 patients who had undergone a surgery for thyroid nodules were included in this study. The presence of the BRAFV600E mutation was determined by allele-specific polymerase chain reaction amplification of exon 15 of the BRAF gene.

Results

Of 69 cases, 33 (47.8%) were BRAFV600E mutation positive. The BRAFV600E mutation was not significantly associated with high-risk features such as tumor size, lymph node metastasis, and pathological stage. The respective diagnostic performance of FNA (P = 0.02), BRAFV600E mutation (P = 0.03), and ultrasonographic (P = 0.00) findings was statistically significant. The sensitivity, specificity and positive predictive value of FNA was 64.9%, 83.3%, and 94.8%. The sensitivity, specificity and positive predictive value of BRAFV600E mutation was 56.1%, 91.7%, and 96.9% and the US features was 91.2%, 91.7%, and 98.1% respectively. However, sensitivity of FNA with BRAFV600E mutation (77.2%) was lower than FNA with US (92.9%) and combination all together (92.9%).

Conclusion

In this study, we found that US features were the most useful in preoperative differential diagnosis of thyroid nodules. BRAFV600E mutation co-testing in FNA cytology was also useful for diagnosis of thyroid tumors.

Obesity and Insulin Resistance According to Age in Newly Diagnosed Type 2 Diabetes Patients in Korea
Ju Won Lee, Nam Kyu Kim, Hyun Joon Park, Jun Yeob Lee, Seon Yoon Choi, Eun Mi Lee, So Young Ock, Su Kyoung Kwon, Young Sik Choi, Bu Kyung Kim
Kosin Med J. 2016;31(2):157-166.   Published online January 20, 2016
DOI: https://doi.org/10.7180/kmj.2016.31.2.157
  • 1,226 View
  • 6 Download
  • 1 Citations
Abstract PDFPubReader   ePub   
Abstract Objectives

With the rapid increase in the prevalence of diabetes, the age groups of diabetic patients are becoming diversified. This study will examine the degree of obesity, insulin resistance, and insulin secretion ability among patients first diagnosed with diabetes according to age and gender.

Methods

The subjects of this study included 616 patients who were first diagnosed with diabetes during a routine physical examination. This sample was obtained from a total of 28,075 adults aged 19 years and older who received the examination among 33,829 participants in the Korea National Health & Nutrition Examination Survey (KNHANES) from 2007–2010. The subjects were categorized by age into young age (age: 19 – 39 years), middle age (age: 40 – 59 years), and old age (age: 60 years and older). The degree of obesity was categorized according to body mass index (BMI) into normal weight (BMI: 18.5 ∼ 22.9), overweight (BMI: 23 ∼ 24.9), and obesity (BMI: 25 or above). Insulin resistance was evaluated by homeostatic model assessment of insulin resistance (HOMA-IR).

Results

It was found that 14.1% (n = 87) of a total of 616 subjects (324 men, 292 women) were in the young age group, 43.8% (n = 270) were in the middle age group, and 42.1% (n = 259) were in the old age group. In addition, 83.3% of men that were overweight or obesity were in the young age group, while 79.2% and 60.5% were in the middle age and old age groups, respectively. A total of 82.2% of women that were overweight or obesity were in the young age group, while 79.5% and 77% were in the middle age and old age groups, respectively. For men, the more obesity they were in all age groups, the higher their HOMA-IR. For women, the more obesity they were in the young age and middle age groups, the higher their HOMA-IR; however, women in the old age group showed the highest HOMA-IR when they were of normal weight.

Conclusion

Among diabetic patients first diagnosed with the disease in Korea, the youth population had the highest obesity rate. Insulin resistance increases as an individual's weight increases among those patients who are first diagnosed with diabetes; the only exception noted is for elderly women.

Citations

Citations to this article as recorded by  
  • Remote health monitoring services in nursing homes
    Jiwon Kim, Hyunsoo Kim, Sungil Im, Youngin Park, Hae-Young Lee, Sookyung Kwon, Youngsik Choi, Linda Sohn, Chulho Oak
    Kosin Medical Journal.2023; 38(1): 21.     CrossRef
Diagnostic Value of Preoperative Serum Thyroglobulin Measurement for the Diagnosis of Malignancy in Follicular or Hürthle Cell Neoplasms of the Thyroid Gland
Nam Kyu Kim, Seong Joo Kang, Weon Hyoung Lee, Go Eun Yeo, You Jin Han, Bu Kyung Kim, Su Kyoung Kwon, Yo-Han Park, Young Sik Choi
Kosin Med J. 2014;29(1):17-22.   Published online December 17, 2014
DOI: https://doi.org/10.7180/kmj.2014.29.1.17
  • 1,208 View
  • 3 Download
Abstract PDFPubReader   
Abstract Objectives

The aim of this retrospective study was whether serum Tg predicts malignancy in follicular or Hürthle-cell neoplasms on fine needle aspiration.

Methods

A chart review of 111 patients (90 females, 21 males; mean age 46.8 ± 11.9 years) with follicular or Hürthle-cell neoplasms on fine needle aspiration, who were surgically treated between Sep. 2001 and Sep. 2011, was performed. Predictive factors for malignancy were identified by the chi-squared test and multivariate logistic regression.

Results

There were no differences between 41 malignant and 70 benign lesions in serum Tg or any of the normalized indexes. Receiver-operator characteristic analysis revealed no cutoff value. Lesions with serum Tg levels greater than 500 g/L had no significant difference. And also there were no independent predictors of malignancy by multivariate logistic regression.

Conclusions

In this study, the author found that serum Tg has poor accuracy for predicting malignancy in follicular or Hürthle cell neoplasms on fine needle aspiration.

Case reports
A Case of Adrenal Tuberculosis with Atypical Clinical Manifestation
Moo Hyun Son, Jung Kyu Park, Hyun Sik Hwang, Byung Ho Kim, Eui Dal Jung, Young Sik Choi
Kosin Med J. 2013;28(2):183-186.   Published online January 19, 2013
DOI: https://doi.org/10.7180/kmj.2013.28.2.183
  • 1,206 View
  • 2 Download
Abstract PDFPubReader   ePub   

Addison’s disease is a rare disorder that causes fatigue, genral weakness, weight loss, pigmentation due to adrenal hypofunction and it’s underlying causes are various. We report a case of 42-year-old man with fatigue, generalized cutaneous pigmentation. Computed tomography showed bilateral adrenal enlargement, but no calcification. Adrenal tuberculosis was established by ultrasound-guided fine needle aspiration biopsy.

A Case of Pulmonary Hypertension Recurred by Graves’ Disease
Jun Seop Lee, Young Sik Choi, Jae Woo Lee, Jin Seok Yoo, Youn Jung Choi, Dong Hyun Park
Kosin Med J. 2013;28(2):171-176.   Published online January 19, 2013
DOI: https://doi.org/10.7180/kmj.2013.28.2.171
  • 1,083 View
  • 1 Download
Abstract PDFPubReader   ePub   

A few cases of severe pulmonary hypertension with right heart failure associated with Graves’ disease were reported in the literature. However, cases of pulmonary hypertension with right heart failure recurred by Graves’ disease is very rare. We describe the case of a 60-year old woman who had been treated pulmonary hypertension caused by right pulmonary artery thromboembolism seven years ago. Recently, her pulmonary hypertension with right heart failure was recurred by Graves’ disease. The patient’s symptoms of pulmonary hypertension was resolved after treatment of Graves’ disease.

A Case of Type III Autoimmune Polyglandular Syndrome
Sangeon Gwoo, Young Sik Choi, Bu Kyung Kim, Yo Han Park, Keun Tae Kim, Jun Seop Lee
Kosin Med J. 2013;28(2):167-170.   Published online January 19, 2013
DOI: https://doi.org/10.7180/kmj.2013.28.2.167
  • 1,247 View
  • 15 Download
Abstract PDFPubReader   ePub   

The autoimmune polyglandular syndromes (APS) are groups of syndromes comprising a combination of endocrine and nonendocrine autoimmune diseases. Among of those four types of APS, the main characteristics of the 3 APS are autoimmune thyroid diseases associated to other autoimmune diseases, excluding Addison’s disease. Type 3 APS are also subdivided into 3A, 3B, 3C, and 3D. Recently, we experience a case of APS manifesting 3A, 3C, and 3D subtype. A 28-year-old woman developed type I diabetes. According to her medical history, she had Graves’ disease, vitiligo, auimmune hemolytic anemia and systemic lupus erythematosus (SLE). The antoantibodies associated with Graves’ disease, SLE, and type I diabetes showed positive findings. We report this case with literatures review.

A Case of Thyrotoxic Periodic Paralysis Associated with Transient Thyrotoxicosis
Hye Jung Kwon, Young Sik Choi, Joon Seup Lee, Dong Hyun Park, Yeon Jung Choi, Jin Seok Yoo
Kosin Med J. 2012;27(2):167-171.   Published online December 27, 2012
DOI: https://doi.org/10.7180/kmj.2012.27.2.167
  • 1,163 View
  • 3 Download
Abstract PDFPubReader   ePub   

Thyrotoxic periodic paralysis is an acute muscle weakness of the limbs associated with hypokalemia. It can occur with any form of thyrotoxicosis. Thyrotoxic periodic paralysis associated with transient thyrotoxicosis due to thyroiditis is very rare. We experienced a case of thyrotoxic periodic paralysis associated with transient thyrotoxicosis. A 39-yr-old man was referred to our hospital because of paralysis of upper and lower extremity. The laboratory results were hypokalemia and mild thyrotoxicosis. A thyroid scan with Tc-99m revealed decreased uptake in the thyroid area compatible with destructive thyroiditis. The paralytic attack did not recur after the patient recovered to euthyroid state.

Original articles
Clinical Characteristics and Expression of BRAFV600E in the Papillary Thyroid Carcinoma Coexisting Hashimoto's Thyroiditis
Sung Jin Nam, Young Sik Choi, Yo Han Park, Jung Hun Kim
Kosin Med J. 2010;25(2):14-19.   Published online December 31, 2010
  • 291 View
  • 1 Download
PDF
Expression of Cathpsin B in the Papillary Thyroid Microcarcinoma
Jae Hong Yang, Young Sik Choi, Yo Han Park, Woo Mi Kim, Jeong Hun Kim, Young Ok Kim
Kosin Med J. 2009;24(2):153-158.   Published online December 31, 2009
  • 321 View
  • 0 Download
PDF
Case reports
A Cases of Chronic Hashimoto's Thyroiditis Associated with Hemiagenesis of Thyroid Gland
Hyun Joo Jung, Ye Na Kim, Young Sik Choi, Yo Han Park
Kosin Med J. 2009;24(1):154-156.   Published online June 30, 2009
  • 299 View
  • 0 Download
PDF
A Case of Diffuse Sclerosing Variant of Papillary Carcinoma
Jung Min Choi, Song Ju Lee, Bu Kyung Kim, young Sik Choi, Yo Han Park, Jun Hun Kim, Bang Hur
Kosin Med J. 2009;24(1):157-160.   Published online June 30, 2009
  • 263 View
  • 0 Download
PDF
Original article
Changes of Markers of Bone Turnover in Premenopausal Patients with Differential Thyroid Cancer Receiving Levo-Thyroxine Suppressive Therapy
Eun young Lee, Young Sik Choi, Yo Han Park, Jeong Hun Kim
Kosin Med J. 2008;23(4):83-87.   Published online December 31, 2008
  • 373 View
  • 0 Download
PDF

KMJ : Kosin Medical Journal
TOP