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19 "Seun Ja Park"
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Original articles
The effects of rebamipide, sucralfate, and rifaximin against inflammation and apoptosis in radiation-induced murine intestinal injury
Won Moon, Sangwook Lim, Yeonsoon Jung, Yuk Moon Heo, Seun Ja Park, Moo In Park, Sung Eun Kim, Jae Hyun Kim, Kyoungwon Jung
Kosin Med J. 2022;37(4):320-341.   Published online December 26, 2022
DOI: https://doi.org/10.7180/kmj.22.140
  • 1,632 View
  • 47 Download
Abstract PDFPubReader   ePub   
Background
Radiotherapy improves overall survival in patients with abdominopelvic malignancies. However, the toxic effects of radiation restrict the maximum dose that can be given, and there are no well-established preventive or therapeutic strategies. This study was conducted to evaluate whether rebamipide, sucralfate, and rifaximin have a suppressive effect on acute ionizing radiation (IR)-induced inflammation in the intestines of mice.
Methods
Thirty-six ICR mice were divided into a vehicle-treated group with sham irradiation; a vehicle-treated group with irradiation; rebamipide, sucralfate, or rifaximin-treated groups with irradiation; and a rebamipide-treated group with sham irradiation. The expression of proinflammatory, anti-inflammatory, proapoptotic, and antiapoptotic factors was investigated.
Results
The downregulated expression of nicotinamide phosphoribosyltransferase by IR was attenuated by all drugs (p<0.05). All drugs suppressed the IR-induced activation of NF-κB and phosphorylation of MAPKs (p<0.05) and attenuated the production of TNF-α, IL-1β, and IL-6 in response to IR (p<0.05). The administration of all drugs markedly attenuated IR-induced increases in iNOS, COX-2, and PGE2 (p<0.05), as well as [Ca2+] oscillations that were increased by IR. The expression of proapoptotic genes and antiapoptotic genes was suppressed and induced, respectively, by all drugs. IR treatment increased the release of cytochrome C, which was attenuated by all drugs (p<0.05). All drug treatments resulted in a significant decrease in the expression of caspase-3 and caspase-7 (p<0.05), which were both upregulated following IR treatment.
Conclusions
The administration of rebamipide, sucralfate, or rifaximin prior to radiation therapy may prevent or attenuate acute radiation-induced enterocolitis.
Differences in Endoscopic Findings of Primary and Secondary Gastric Lymphoma
Kyoungwon Jung, Hae Soo Jeon, Moo In Park, Il Hyeong Choe, Hyun Seung Je, Jae Hyun Kim, Sung Eun Kim, Won Moon, Seun Ja Park
Kosin Med J. 2020;35(2):114-124.   Published online December 31, 2020
DOI: https://doi.org/10.7180/kmj.2020.35.2.114
  • 1,634 View
  • 14 Download
  • 2 Citations
Abstract PDFPubReader   ePub   
Objectives

: Since endoscopic findings of primary gastric lymphoma are ambiguous and diverse, it is not easy to distinguish them from gastric adenocarcinoma or secondary gastric lymphoma. The aim of this study was to investigate the difference in clinical and endoscopic features between primary gastric lymphoma and gastric involvement of lymphoma.

Methods

: Forty-eight patients were enrolled in this retrospective study between June 2008 and February 2017. The patients were divided into primary gastric lymphoma group (primary group, n = 18) and gastric involvement group (secondary group, n = 30) based on whether or not they carried gastric lesions alone. Patients’ clinical characteristics, endoscopic findings and pathologic data were retrospectively reviewed based on electronic medical records.

Results

: The mean age of patients was 63.3 ± 13.1 years and 29 patients were female (60.4%). Diffuse large B-cell lymphoma pathology (81.3%), gastric body involvement (47.9%) and ulceroinfiltrative morphology on endoscopy (43.8%) were common features. Regardless of the two groups, the initial endoscopic diagnosis was considered as lymphoma only in 41.7%. Compared with the primary group, fundus (P = 0.035) and regional lymph node (P < 0.001) were significantly associated with the secondary group. However, there was no significant difference in endoscopic findings including location, size, number, and morphology of lesion.

Conclusions

: Endoscopic diagnosis of gastric lymphoma is a challenge. There is no difference in endoscopic findings between the primary and secondary groups even when confirmed separately. However, when the lesion is present in the fundus, we keep in mind the possibility of secondary gastric lymphoma.

Citations

Citations to this article as recorded by  
  • Endoscopic and Histopathological Characteristics of Gastrointestinal Lymphoma: A Multicentric Study
    Quang Trung Tran, Thinh Nguyen Duy, Bao Song Nguyen-Tran, Tung Nguyen-Thanh, Quy Tran Ngo, Nam Phuong Tran Thi, Vi Le, Thuan Dang-Cong
    Diagnostics.2023; 13(17): 2767.     CrossRef
  • A Differential Diagnosis of Unusual Gastric Ulcer
    Soo-Yoon Sung, Hyun Ho Choi, Kyung Jin Seo
    Diagnostics.2022; 12(8): 1929.     CrossRef
Case report
A Case of needle-tract implantation of hepatocellular carcinoma in the ovary after radiofrequency ablation
Seong Woon Yoon, Jin-Sook Jeong, Su Young Kim, Sung Wook Lee, Seun Ja Park
Kosin Med J. 2017;32(2):251-257.   Published online January 19, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.2.251
  • 1,124 View
  • 7 Download
  • 2 Citations
Abstract PDFPubReader   ePub   

Radiofrequency ablation (RFA), a local ablative modality, is gaining acceptance for the treatment of liver malignancies. Despite a relatively low complication rate, tumor seeding resulting from RFA in hepatocellular carcinoma (HCC) treatment can occur. A 44-year-old woman was diagnosed with HCC. Spiral computed tomography (CT) revealed a 2.3 × 2.0-cm mass in the S5 segment, which was treated with RFA on May, 2005. Follow-up imaging, performed at 6-month intervals after RFA, showed complete tumor necrosis. In October 2009, CT revealed a heterogeneous mass, 5.7 cm in diameter, in the right ovary. Since the lesion was limited to the right ovary without evidence of spread, bilateral salpingo-oophorectomy was performed. Histopathology indicated that the metastatic spread from the HCC to the ovary was positive for hepatocyte-specific antigen on immunohistochemistry. The ovary is a rare site for HCC metastasis. Moreover, needle tract implantation of HCC in the ovary is very rare.

Citations

Citations to this article as recorded by  
  • A case of hepatocellular carcinoma with metastasis to the ovary
    Haruka AKAJI (KAJIO), Tomoko KURITA, Ryosuke TAJIRI, Hiroshi HARADA, Taeko UEDA, Kiyoshi YOSHINO, Haruko OKA, Nobuyuki TERADO, Aya NAWATA, Yusuke MATSUURA
    The Journal of the Japanese Society of Clinical Cytology.2023; 62(6): 300.     CrossRef
  • Long-term survival of 11 years with multidisciplinary therapy for hepatocellular carcinoma metastasis to the ovary and peritoneum: a case report
    Satoko Motegi, Takeshi Yokoo, Ryosuke Nozawa, Rie Azumi, Yuzo Kawata, Kohei Ogawa, Toru Setsu, Ken-ichi Mizuno, Koji Nishino, Hajime Umezu, Hirokazu Kawai, Takeshi Suda, Shuji Terai
    Clinical Journal of Gastroenterology.2021; 14(4): 1211.     CrossRef
Original articles
A Case of Ischemic Colitis Related with Usual Dosage of Ibuprofen in a Young Man
Eun Jeong Kim, Moo In Park, Seun Ja Park, Won Moon, Go Eun Yeo, Weon Hyoung Lee
Kosin Med J. 2014;29(2):147-150.   Published online December 18, 2014
DOI: https://doi.org/10.7180/kmj.2014.29.2.147
  • 981 View
  • 2 Download
Abstract PDFPubReader   
Abstract

Ischemic colitis is a medical condition in which inflammation and injury of the large intestine result from inadequate blood supply. Although unoommon in the general p㢌pulation, ischemic colitis occurs with greater frequency in the elderly, and is the most common form of bowel ischemia. Other possible causes include medications s䴸ch as NSAIDs(non-steroidal antiinflammatory drugs), oral contraceptives, diuretics and others. In recent years, many of NSAID use in young age can cause ischemic lesions, but it is not common. Here we report a case of ischemic colitis in a 31-year-old man who had no specific medical history except taking 200mg of ibuprofen three times a day for seven days. It suggests the importance of precise history taking, including medications usage such as NSAIDs and other risk factors.

Characteristics of Clinical Features between Isolated Left Side Ischemic Colitis and Non-Isolated Left Side Ischemic Colitis
Jae Joon Heo, Hyung Hun Kim, Jun Young Song, Seun Ja Park, Moo In Park, Won Moon
Kosin Med J. 2013;28(2):99-106.   Published online January 19, 2013
DOI: https://doi.org/10.7180/kmj.2013.28.2.99
  • 1,140 View
  • 1 Download
Abstract PDFPubReader   ePub   
Objectives

Compared with all other patterns, isolated right colon ischemia has been found to be more associated with coronary artery disease and a poor prognosis. However, there has been no research on comparing isolated left side ischemic colitis (ILIC) and non-ILIC with vascular assessment. The aim of the present study was to evaluate the clinical and laboratory findings between these two different forms of ischemic colitis (IC).

Methods

We retrospectively investigated differences in clinical features, course, and mesenteric vascular (superior mesenteric artery, SMA; inferior mesenteric artery, IMA) findings between ILIC and non-ILIC patients who were hospitalized at Kosin University Gospel Hospital from 2004 to 2010.

Results

Our study population comprised 221 patients, all of whom met our entry criteria of biopsy-proven or -compatible IC. Of the 221 patients, 46 (20.8%) had non-ILIC. Congestive heart failure and hypercholesterolemia were more frequently observed in the non-ILIC group (P = 0.003 and P = 0.020, respectively). SMA atherosclerosis and SMA stenosis were more frequently observed in the non-ILIC group (P = 0.006 and P = 0.001, respectively). Recovery periods were longer in the non-ILIC group (P = 0.039), and mortality was lower in the ILIC group (6.9% vs. 17.3%, P = 0.026).

Conclusions

ILIC has favorable outcomes compared with non-ILIC. Furthermore, non-ILIC showed a close relationship with SMA atherosclerosis and SMA stenosis, which should be investigated carefully in the clinical field.

Case reports
Two Cases of Symptomatic Limy Bile in the Bile Duct
Sung Woo Yoon, Jee Young Lee, Kyung Ho Ha, Su Kyeong Lee, Na Han, Hyo Keun Bae, Seun Ja Park
Kosin Med J. 2010;25(2):141-145.   Published online December 31, 2010
  • 253 View
  • 1 Download
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Cerebral Venous Sinus Thrombosis in a Patient with Crohn Disease
So Young Huh, Jong Kuk Kim, Seun Ja Park
Kosin Med J. 2009;24(1):190-192.   Published online June 30, 2009
  • 240 View
  • 0 Download
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A Case of PTEN Gene Mutations Associated with Cowden's Disease
Sung Jin Nam, Young Sik Choi, Yo Han Park, Kyu Jong Kim, Seun Ja Park
Kosin Med J. 2008;23(4):239-242.   Published online December 31, 2008
  • 212 View
  • 0 Download
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A Case of Pneumomediastinum, Subcutaneous Emphysema, and Tension Pneumothorax after ERCP
Yong Gun Jo, Hyun Seung Lee, Kyun Hong Kwon, Ja Young Kim, Bong Jin Kim, Jee Yeon Kim, Yong Mock Bae, Seun Ja Park
Kosin Med J. 2008;23(4):258-260.   Published online December 31, 2008
  • 199 View
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A Case of Gastric Schwannoma with Enlargement of Size within 3 Years
Do Hyun Kim, Moo In Park, Chan Hui Yoo, Kyu Jong Kim, Won Moon, Seun Ja Park, Hee Kyung Jang
Kosin Med J. 2008;23(2):126-129.   Published online June 30, 2008
  • 199 View
  • 1 Download
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A Case of Juvenile polyp arising from Right sided Colon
Jun Sik Lee, Sung Han Park, Hyun Jin Hong, Kwang Soon Ahn, Jee Yeon Kim, Yong Mock Bae, Eun Young Lee, Seun Ja Park
Kosin Med J. 2007;22(2):177-180.   Published online December 31, 2007
  • 188 View
  • 0 Download
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Original article
Clinical findings and risk factors for Candida esophagitis
Sun Young Kim, Seung Hun Lee, Sung Hoon Kim, Jae Seung Lee, Hee Seung Park, Sung Ho Choi, Seun Ja Park
Kosin Med J. 2007;22(1):206-211.   Published online June 30, 2007
  • 229 View
  • 0 Download
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Case report
A case of Spontaneous esophageal submucosal dissection on esophageal candidiasis
Seung Heon Lee, Sun Young Kim, Kyung Won Yun, Seong Woo Lee, Sung Hoon Kim, Jae Seung Lee, Hee Seung Park, Sung Ho Choi, Seun Ja Park
Kosin Med J. 2007;22(1):270-274.   Published online June 30, 2007
  • 233 View
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Original article
The Effect of amiloride on the Growth of Hepatocellular Carcinoma Cells
Chae Hee Shin, Ki Ryong Park, Byung Ju Choi, Soo Hong Seo, Kim Sung Hoon, Moo In Park, Seun Ja Park, Kun Ok Chung, Kun Young Park, Ja Young Koo
Kosin Med J. 2002;17(1):25-34.
  • 284 View
  • 0 Download
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Case report
A Case of Primary Small Cell Carcinoma of the stomach
Seoung Hoon Kim, Jee Yeon Kim, Hyun Young Kim, Chae Hee Shin, Dong Wan Kim, Ki Hwan Kim, Hyeong Young Park Moo In Park, Seun Ja Park, Ja Young Koo
Kosin Med J. 2002;17(1):157-160.
  • 268 View
  • 0 Download
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KMJ : Kosin Medical Journal