KOSIN UNIVERSITY COLLEGE OF MEDICINE
Search
- Page Path
- HOME > Search
Original article
- Comparative analysis of Access PCT and Elecsys BRAHMS PCT assays for procalcitonin measurements
- Hyunji Choi, Sang-Shin Lee, Hyunyong Hwang
- Kosin Med J. 2024;39(4):272-280. Published online December 20, 2024
- DOI: https://doi.org/10.7180/kmj.24.155
- 7,051 View
- 133 Download
- 4 Citations
-
Abstract
PDF
PubReader 
ePub
- Background
Procalcitonin (PCT) is a crucial biomarker for diagnosing sepsis and managing antibiotic therapy. This study evaluated the analytical performance and comparability of the Access PCT and Elecsys BRAHMS PCT assays.
Methods
The precision, detection capability, linearity, and reference range of both assays were assessed. A comparative analysis included 182 patient samples categorized into four risk groups to compare the results between Access PCT and Elecsys BRAHMS PCT assays.
Results
The Access PCT assay demonstrated precision within the manufacturer’s threshold, and its detection capabilities were verified. This assay exhibited excellent linearity and appropriate reference intervals. Comparative analysis indicated that the Access PCT assay reported higher overall PCT levels than the Elecsys BRAHMS assay, with high agreement between the assays (κ=0.941). However, the biases varied across different PCT concentration intervals.
Conclusions
Both the Access PCT and Elecsys BRAHMS PCT assays performed robustly with notable concordance but varying biases at different concentration intervals. The observed biases require careful consideration in clinical decision-making, especially when adopting novel assay systems. Standardizing the calibration across different platforms is recommended to improve assay comparability. -
Citations
Citations to this article as recorded by
- Comparative evaluation of multimodal point-of-care tests to differentiate gram-negative from gram-positive infections in critically ill adults: a diagnostic accuracy study
Weijia Huang, Ting Yang, Sinan Ma, Jiatian Wang, Huangxin Gong, Haitao Wang, Jingying Sun, Na Wang, Li Zhang, Yan Wang
Infection.2026; 54(2): 863. CrossRef - KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initi
Márton Papp, Caner Turan, Nikolett Kiss, László Zubek, Dilan Márk Karim, Péter Hegyi, Zsolt Molnár
BMJ Open.2026; 16(5): e115344. CrossRef - Comparative performance of automated immunoassay systems for procalcitonin measurement: Vidas B.R.A.H.M.S vs. Maglumi
Nuray Arı, Hatice Handan Akbulut
Turkish Journal of Biochemistry.2026;[Epub] CrossRef - Comparative evaluation of two automated immunoassays for serum thyroglobulin quantification
Kyoung Ho Roh, Hyunyong Hwang
Kosin Medical Journal.2025; 40(3): 213. CrossRef
- Comparative evaluation of multimodal point-of-care tests to differentiate gram-negative from gram-positive infections in critically ill adults: a diagnostic accuracy study
First
Prev
