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From articles published since 2012.

Original article
Effects of L-ascorbic acid on the production of pro-inflammatory and anti-inflammatory cytokines in C57BL/6 mouse splenocytes
Eun Hee Kong, Sun Young Ma, Jee Yeong Jeong, Kwang Hyuk Kim
Kosin Med J. 2015;30(1):41-49.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.1.41
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  • 13 Citations
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Abstract Objective

The imbalance between pro-inflammatory and anti-inflammatory cytokines may underlie different pain states. Although ascorbic acid is the most important physiological antioxidant that affects host defense mechanisms and immune homeostasis, there is limited information on the effects of ascorbic acid on the production of cytokines.

Methods

In this study, we investigated the in vitro effect of L-ascorbic acid (AA) on the production of pro-inflammatory and anti-inflammatory cytokines by stimulating C57BL/6 mouse splenocytes with the polyclonal activators lipopolysaccharide or concanavalin A.

Results

AA significantly downregulated the expression of IL-6, IL-12, and TNF-α at 48 h and 72 h in mouse splenocytes treated with a combination of polyclonal activators and AA. AA treatment also resulted in upregulation of IL-4 and IL-10 at 72 h. These findings demonstrated that AA significantly potentiated production of anti-inflammatory cytokines whereas there was an inverse association between AA and expression of pro-inflammatory cytokines in mouse splenocytes.

Conclusion

AA may have potential applications in the reduction of inflammatory pain because of its function in modulating the production of cytokines. However, further in vivo investigations are necessary to elucidate the mechanisms involved.

Citations

Citations to this article as recorded by  
  • Sitagliptin Attenuates the Cognitive Deficits in L-Methionine-Induced Vascular Dementia in Rats
    Suzan A. Khodir, Manar A. Faried, Huda I. Abd-Elhafiz, Eman M. Sweed, Krzysztof Siemianowicz
    BioMed Research International.2022; 2022: 1.     CrossRef
  • Combination Treatment of Omega-3 Fatty Acids and Vitamin C Exhibited Promising Therapeutic Effect against Oxidative Impairment of the Liver in Methotrexate-Intoxicated Mice
    Mohammed Alorabi, Doha Saad Mohammed, Gomaa Mostafa-Hedeab, Suzy A. El-Sherbeni, Walaa A. Negm, Ali Ismail A. Mohammed, Hayder M. Al-kuraishy, Nani Nasreldin, Saqer S. Alotaibi, Bashir Lawal, Gaber El-Saber Batiha, Carlos Adam Conte-Junior, Valeria Pasciu
    BioMed Research International.2022; 2022: 1.     CrossRef
  • STAT3 inhibition decreases ATP-induced MUC8 gene expression in human airway epithelial cells
    Cheol Hong Kim, Kyoung Seob Song
    Kosin Medical Journal.2022; 37(2): 134.     CrossRef
  • Critical review on the immunomodulatory activities of carrot’s β-carotene and other bioactive compounds
    Gemala Anjani, Fitriyono Ayustaningwarno, Rafika Eviana
    Journal of Functional Foods.2022; 99: 105303.     CrossRef
  • Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
    Agnieszka Gęgotek, Elżbieta Skrzydlewska
    Antioxidants.2022; 11(10): 1993.     CrossRef
  • The Effect of Ascorbic Acid on Interleukin-10 and Tumor Necrosis Factor-α Cytokines in Rattus norvegicus with Endometritis
    Muhammad Oky Prabudi, M. F. G. Siregar, I. P. A. Nasution, S. Ilyas
    Open Access Macedonian Journal of Medical Sciences.2021; 9(A): 798.     CrossRef
  • Effect of Ascorbic Acid on Differentiation, Secretome and Stemness of Stem Cells from Human Exfoliated Deciduous Tooth (SHEDs)
    Shilpa Bhandi, Ahmed Alkahtani, Mohammed Mashyakhy, Abdulaziz S. Abumelha, Nassreen Hassan Mohammad Albar, Apathsakayan Renugalakshmi, Mazen F. Alkahtany, Ali Robaian, Asma Saleh Almeslet, Vikrant R. Patil, Saranya Varadarajan, Thodur Madapusi Balaji, Rod
    Journal of Personalized Medicine.2021; 11(7): 589.     CrossRef
  • Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research
    Hui Yee Tan, Sik Loo Tan, Seow Hui Teo, Margaret M. Roebuck, Simon P. Frostick, Tunku Kamarul
    PeerJ.2020; 8: e8740.     CrossRef
  • Active Cousinia thomsonii Extracts Modulate Expression of Crucial Proinflammatory Mediators/Cytokines and NFκB Cascade in Lipopolysaccharide-Induced Albino Wistar Rat Model


    Khalid Bashir Dar, Ishfaq Shafi Khan, Shajrul Amin, Aijaz Hassan Ganie, Aashiq Hussain Bhat, Showkat Ahmad Dar, Bilal Ahmad Reshi, Showkat Ahmad Ganie
    Journal of Inflammation Research.2020; Volume 13: 829.     CrossRef
  • The potential cytoprotective effect of Vitamin C and Vitamin E on monosodium glutamate-induced testicular toxicity in rats
    Safaa Mohamed El Kotb, Dalia El-sayed El-ghazouly, Omnia Ameen
    Alexandria Journal of Medicine.2020; 56(1): 134.     CrossRef
  • Combination of ascorbic acid and calcitriol attenuates chronic asthma disease by reductions in oxidative stress and inflammation
    Farzaneh Kianian, Seyed Morteza Karimian, Mehri Kadkhodaee, Nasrin Takzaree, Behjat Seifi, Soheila Adeli, Elham Harati, Hamid Reza Sadeghipour
    Respiratory Physiology & Neurobiology.2019; 270: 103265.     CrossRef
  • Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens
    Daniel Hernandez-Patlan, Bruno Solis-Cruz, Karine P. Pontin, Juan D. Latorre, Xochitl Hernandez-Velasco, Ruben Merino-Guzman, Abraham Mendez-Albores, Billy M. Hargis, Raquel Lopez-Arellano, Guillermo Tellez-Isaias
    Pathogens.2019; 8(4): 229.     CrossRef
  • Amelioration ofEscherichia coli-induced endometritis with ascorbic acid in non-pregnant mouse models
    Enitome Evi Bafor, Ikechukwu Onwukpa, Anne Oghenekevwe Itemire, Osemelomen Omoruyi, Ejiroghene Eferoba-Idio, Kevin Odega, Osas Jim Eghianruwa
    American Journal of Reproductive Immunology.2018; 80(3): e12976.     CrossRef
Review article
Aging of the respiratory system
Seung Hun Lee, Su Jin Yim, Ho Cheol Kim
Kosin Med J. 2016;31(1):11-18.   Published online February 4, 2016
DOI: https://doi.org/10.7180/kmj.2016.31.1.11
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Abstract

Changes in the respiratory system caused by aging generally include structural changes in the thoracic cage and lung parenchyma, abnormal findings on lung function tests, ventilation and gas exchange abnormalities, decreased exercise capacity, and reduced respiratory muscle strength. Decreased respiratory system compliance caused by reduced elastic recoil of the lung parenchymaand thoracic cage is related to decreased energy expenditure by the respiratory system. Lung function, as measured by 1-second forced expiratory volume and forced vital capacity (FVC), decreases with age, whereas total lung capacity remains unchanged. FVC decreases because of increased residual volume and diffusion capacity also decreases. Increased physiological dead space and ventilation/perfusion imbalance may reduce blood oxygen levels and increase the alveolar-arterial oxygen difference. More than 20% decrease in diaphragmstrength is thought to beassociated withaging-related muscle atrophy. Ventilation per minute remains unchanged, and blood carbon dioxide concentration does not increase with aging. However, responses to hypoxia and hypercapnia are decreased. Exercise capacity also decreases, and maximum oxygen consumption decreases by >1%/year. Consequence of these changes, many respiratory diseases occur with aging. Thus, it is important to recognize these aging-related respiratory system changes.

Citations

Citations to this article as recorded by  
  • Activities of Daily Living and Related Factors in Elderly Patients with Pulmonary Disease Preparing for Discharge
    Hyunwoo Jeong, Sanghee Kim, Mona Choi, Eui Geum Oh
    Korean Journal of Adult Nursing.2022; 34(4): 391.     CrossRef
  • Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
    Anteneh Mehari Tizazu, Hylemariam Mihiretie Mengist, Gebreselassie Demeke
    Immunity & Ageing.2022;[Epub]     CrossRef
  • Determinants of dynamic inspiratory muscle strength in healthy trained elderly
    A Roldán, A Forte, P Monteagudo, A Cordellat, J Monferrer-Marín, C Blasco-Lafarga
    Postgraduate Medicine.2021; 133(7): 807.     CrossRef
  • Comparison of Voice-Related Quality of Life for the Elderly with and without Voice Disorders According to Genders by Aging Voice Index-Korean Version
    Hwa-Young Pyo, Jae-Yol Lim, Sung-Eun Lim, Seung Jin Lee
    Communication Sciences & Disorders.2021; 26(4): 933.     CrossRef
  • Age‐related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review
    Benjamin Zimmerman, Bart Rypma, Gabriele Gratton, Monica Fabiani
    Psychophysiology.2021;[Epub]     CrossRef
  • Perubahan Fungsi Paru Pada Usia Tua
    Helmia Hasan, Rena Arusita Maranatha
    Jurnal Respirasi.2019; 3(2): 52.     CrossRef
  • Possibilities of modern anesthetic management of laparoscopic cholecystectomy in elderly patients
    O. V. Bielykh
    Problems of Uninterrupted Medical Training and Science.2019; 2019(2): 84.     CrossRef
  • Beneficial Effects of Inspiratory Muscle Training Combined With Multicomponent Training in Elderly Active Women
    Ainoa Roldán, Ana Cordellat, Pablo Monteagudo, Consolación García-Lucerga, Nieves M. Blasco-Lafarga, Mª Carmen Gomez-Cabrera, Cristina Blasco-Lafarga
    Research Quarterly for Exercise and Sport.2019; 90(4): 547.     CrossRef
  • Factors Affecting Lung Function: A Review of the Literature
    Alejandro Talaminos Barroso, Eduardo Márquez Martín, Laura María Roa Romero, Francisco Ortega Ruiz
    Archivos de Bronconeumología (English Edition).2018; 54(6): 327.     CrossRef
  • Factores que afectan a la función pulmonar: una revisión bibliográfica
    Alejandro Talaminos Barroso, Eduardo Márquez Martín, Laura María Roa Romero, Francisco Ortega Ruiz
    Archivos de Bronconeumología.2018; 54(6): 327.     CrossRef
  • Normal aging: definition and physiologic changes
    Chul Ho Chang, Ki-Young Lee, Yon Hee Shim
    Journal of the Korean Medical Association.2017; 60(5): 358.     CrossRef
Case report
Spontaneous Coronary Artery Dissection in a female patient with fragile X syndrome
Hyun-Young Park, Jin-Man Cho, Dong-Hee Kim, Chang-Bum Park, Chong-Jin Kim
Kosin Med J. 2017;32(2):240-243.   Published online January 19, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.2.240
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  • 4 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM

We report a case of Spontaneous coronary artery dissection associated with fragile X syndrome. The relationship between fragile X syndrome and Spontaneous coronary artery dissection is unclear. However, More research will need about the causes and treatment of Spontaneous coronary artery dissection.

Citations

Citations to this article as recorded by  
  • Hypermobile Ehlers-Danlos syndrome (hEDS) phenotype in fragile X premutation carriers: case series
    Nattaporn Tassanakijpanich, Forrest J McKenzie, Yingratana A McLennan, Elisabeth Makhoul, Flora Tassone, Mittal J Jasoliya, Christopher Romney, Ignacio Cortina Petrasic, Kaye Napalinga, Caroline B Buchanan, Paul Hagerman, Randi Hagerman, Emily L Casanova
    Journal of Medical Genetics.2022; 59(7): 687.     CrossRef
  • Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing
    Ingrid Tarr, Stephanie Hesselson, Siiri E. Iismaa, Emma Rath, Steven Monger, Michael Troup, Ketan Mishra, Claire M.Y. Wong, Pei-Chen Hsu, Keerat Junday, David T. Humphreys, David Adlam, Tom R. Webb, Anna A. Baranowska-Clarke, Stephen E. Hamby, Keren J. Ca
    Circulation: Genomic and Precision Medicine.2022;[Epub]     CrossRef
  • Spontaneous Coronary Artery Dissection in Females With the Fragile X FMR1 Premutation
    Forrest J. McKenzie, Nattaporn Tassanakijpanich, Kelly C. Epps, S. Kimara March, Randi J. Hagerman
    JACC: Case Reports.2020; 2(1): 40.     CrossRef
  • Cardiovascular Problems in the Fragile X Premutation
    Nattaporn Tassanakijpanich, Jonathan Cohen, Rashelle Cohen, Uma N. Srivatsa, Randi J. Hagerman
    Frontiers in Genetics.2020;[Epub]     CrossRef
Original articles
Antinociceptive Effect of BPC-157 in the Formalin-induced Pain Model
Sang Yoong Park, So Ron Choi, Jeong Ho Kim, Seung Cheol Lee, Seong Yeop Jeong, Joon Ho Jeong, Tae Young Lee
Kosin Med J. 2021;36(1):1-13.   Published online June 30, 2021
DOI: https://doi.org/10.7180/kmj.2021.36.1.1
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  • 3 Citations
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Objectives

Body protective compound-157 (BPC-157) is a stable gastric pentadecapeptide that has been effective in trials aiming to increase wound healing capabilities and decrease inflammatory cell influx, including studies on the healing of muscles and tendons. There are no studies about the effect of BPC-157 on pain transmission via nociception. This study examined the antinociceptive effects of BPC-157 using formalin tests and immunohistochemistry.

Methods

Rats were randomly divided into the control, morphine and BPC-157 groups. Pain behavior was quantified periodically at 5- and 35- min intervals (representative values of phases 1 and 2) by counting the number of flinches exhibited by the injected paw after injection. The dorsal root ganglia (DRG) and spinal cords (SC) were collected, and then, the number of cytokine-positive cells was determined via immunostaining.

Results

BPC-157 dose-dependently decreased the number of flinches during phase 1 but did not decrease the number of flinches during phase 2. During phase 1, interleukin-1β (IL-1β) in the DRG tissue was significantly different in the morphine, 10 μg/kg BPC-157, and 20 μg/kg BPC-157 groups. During phase 2, statistical significance was achieved in the DRG tissue in the morphine, 20 μg/kg BPC-157, and 40 μg/kg BPC-157 groups. During phase 1, interleukin-6 was significantly different in the DRG tissue in the morphine group and the SC tissue in the 10 μg/kg BPC-157 group. During phase 2, statistical significance was achieved in the morphine group and the BPC-157 20 μg/kg group in both the DRG and SC tissues. There were no significant differences in tumor necrosis factor-α between the DRG and SC tissues.

Conclusions

BPC-157 was effective during phase 1 but not during phase 2, as determined by the formalin test. BPC-157 decreased the expression of IL-1β in the DRG tissue in phases 1 and 2.

Citations

Citations to this article as recorded by  
  • The anti-nociceptive effect of BPC-157 on the incisional pain model in rats
    Young-Hoon Jung, Haekyu Kim, Hyaejin Kim, Eunsoo Kim, Jiseok Baik, Hyunjong Kang
    Journal of Dental Anesthesia and Pain Medicine.2022; 22(2): 97.     CrossRef
  • Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation
    Predrag Sikiric, Mario Udovicic, Ivan Barisic, Diana Balenovic, Gordana Zivanovic Posilovic, Dean Strinic, Sandra Uzun, Suncana Sikiric, Ivan Krezic, Helena Zizek, Haidi Yago, Slaven Gojkovic, Ivan Maria Smoday, Luka Kalogjera, Hrvoje Vranes, Marija Sola,
    Biomedicines.2022; 10(11): 2696.     CrossRef
  • Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle
    Mario Staresinic, Mladen Japjec, Hrvoje Vranes, Andreja Prtoric, Helena Zizek, Ivan Krezic, Slaven Gojkovic, Ivan Maria Smoday, Katarina Oroz, Eva Staresinic, Vilim Dretar, Haidi Yago, Marija Milavic, Suncana Sikiric, Eva Lovric, Lovorka Batelja Vuletic,
    Biomedicines.2022; 10(12): 3221.     CrossRef
Genipin Inhibits Hypoxia-Induced Accumulation of HIF-1α and VEGF Expressions in Human Cervical Carcinoma Cells
Cho Eui Jin, Jung Hyun Lee, Geun Joo Kim, Tae Hwa Lee
Kosin Med J. 2019;34(2):106-116.   Published online December 31, 2019
DOI: https://doi.org/10.7180/kmj.2019.34.2.106
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  • 3 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

Hypoxia—a characteristic of almost all types of solid tumors—has been associated with poor outcomes in several human malignancies. Genipin—an active constituent of Gardenia fruit— has been reported to exert an anti-tumor effect in several cancers. In this study, we investigated inhibition of angiogenesis using Genipin-mediated hypoxia-induced hypoxia inducible factor (HIF-1) and VEGF expression in human cervical cancer cells.

Methods

Under normoxic and hypoxic conditions, the expression of HIF-1α and VEGF in cervical cancer HeLa cells was detected by quantitative reverse transcription polymerase chain reaction and western blotting. Luciferase reporter assays were used to investigate the molecular mechanisms underlying the hypoxia-induced survivin activation.

Results

Surprisingly, we found that Genipin suppressed the HIF-1α accumulation during hypoxia in human liver cancer cell line (HepG2), human prostate cancer cell line (LNCaP), colon cancer cell line (HCT116), and breast cancer cell line (MDA231). Genipin treatment also significantly reduced hypoxia-induced secretion of VEGF.

Conclusions

Suppression of HIF-1α accumulation following treatment with Genipin under hypoxia was associated with PI3K and MAPK pathways. Taken together, these results suggested that Genipin inhibits HIF-1α expression through inhibition of PI3K and MAPK signaling pathways. These results provide new insights into a potential mechanism of the anticancer properties of Genipin.

Citations

Citations to this article as recorded by  
  • Novel Findings regarding the Bioactivity of the Natural Blue Pigment Genipin in Human Diseases
    Magdalena Bryś, Karina Urbańska, Beata Olas
    International Journal of Molecular Sciences.2022; 23(2): 902.     CrossRef
  • The Effects of Natural and Synthetic Blue Dyes on Human Health: A Review of Current Knowledge and Therapeutic Perspectives
    Beata Olas, Jacek Białecki, Karina Urbańska, Magdalena Bryś
    Advances in Nutrition.2021; 12(6): 2301.     CrossRef
  • Polyphenols Extracted from Chinese Hickory (Carya cathayensis) Promote Apoptosis and Inhibit Proliferation through the p53-Dependent Intrinsic and HIF-1α-VEGF Pathways in Ovarian Cancer Cells
    Zhiping He, Shaozhen Wu, Ju Lin, Ashley Booth, Gary O’Neal Rankin, Ivan Martinez, Yi Charlie Chen
    Applied Sciences.2020; 10(23): 8615.     CrossRef
The Study in Vitamin D Concentration in the Blood for Infants with High Level of Alkaline Phosphatase
Ji Sung Kim, Jae Yong Choi, Kyun Woo Lee, Ick Jin Song, Cheol Am Kim, Byeong Hee Son, Jung Hyun Lee
Kosin Med J. 2012;27(1):17-24.   Published online June 11, 2012
DOI: https://doi.org/10.7180/kmj.2012.27.1.17
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  • 3 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

Nowadays most infants on exclusively breast feeding have vitamin D deficiency due to the increase of breast feeding. However, domestic research lacks appropriate materials. Therefore, we researched practical clinical aspects of vitamin D deficiency related to breast milk feeding for infants who have a high amount of alkaline phosphatase (> 500 IU/L).

Methods

The subjects of the study were 31 infants with high alkaline phosphatase level. We tested with 25-hydroxycholecalciferol (25-OHD3), parathyroid hormone, calcium, ionized calcium, phosphorus in their blood and with a wrist x-ray. Then, we divided them into two groups of breast feeding and formula feeding and compared the results.

Results

Eighteen infants (58%) out of 31 infants that have high alkaline phosphatase were vitamin D insufficiency or deficiency, and 16 (100%) breast feeding infants of them showed vitamin D deficiency or insufficiency. However, only 2 (13%) of 15 formula feeding infants were at insufficiency. There was a correlation between alkaline phosphatase and 25-OHD3 concentration in multiple regression analysis, but no correlation in other variables was found in group of breast milk feeding infants. There was neither correlation between vitamin D concentration and alkaline phosphatase nor other correlated variables in the group of formula milk feeding infants.

Conclusions

In this study, there was a high probability of vitamin D deficiency in the breast feeding infants with a high alkaline phosphatase level. Therefore, it is considered to be worth utilizing alkaline phosphatase as a screening test for vitamin D deficiency or rickets for breast feeding infants.

Citations

Citations to this article as recorded by  
  • The Role of Vitamin D in Menopausal Medicine
    Mijin Kim, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Min-Jung Oh
    Kosin Medical Journal.2016; 31(2): 97.     CrossRef
  • The Role of Vitamin D in Menopausal Medicine
    Mijin Kim, Tae-Hee Kim, Hae-Hyeog Lee, Heung Yeol Kim, Min-Jung Oh
    Kosin Medical Journal.2016; 31(2): 97.     CrossRef
  • Recent Updates on Vitamin D and Pediatric Gastrointestinal Diseases
    Ji-Hyun Seo, Ju Young Chang, Ji Sook Park, Chan-Hoo Park, Hee-Shang Youn
    Pediatric Gastroenterology, Hepatology & Nutrition.2012; 15(3): 138.     CrossRef
Review articles
How to conduct well-designed clinical research
Da Jung Kim, Song Yi Kil, Jongwon Son, Ho Sup Lee
Kosin Med J. 2022;37(3):187-191.   Published online September 27, 2022
DOI: https://doi.org/10.7180/kmj.22.122
  • 516 View
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  • 2 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Clinicians and healthcare decision-makers conduct their clinical practice based on the results of clinical trials. However, some health problems remain unresolved; in such cases, further research is required. To ensure reliable research results, it is important to understand the study design and conduct well-designed clinical trials. Many study designs can be chosen within the two broad categories of observational and interventional. Clinical studies have a variety of designs, including case series, case-control, cross-sectional, and prospective and retrospective cohort studies. Well-designed clinical studies can clarify important differences between treatment options and provide data on long-term drug efficacy and safety. Interpreting the results of clinical trials can be difficult because weaknesses in research design, data collection methods, analytic methods, and reporting can compromise their value and usefulness. However, although randomized controlled trials are limited owing to ethical and practical issues, they are optimal for investigating the effects of therapy and establishing causality. Here we present an overview of different clinical research designs and review their advantages and limitations.

Citations

Citations to this article as recorded by  
  • Evaluation of automated calibration and quality control processes using the Aptio total laboratory automation system
    Namhee Kim, Yein Kim, Jeongeun Park, Jungsoo Choi, Hyunyong Hwang
    Kosin Medical Journal.2022; 37(4): 342.     CrossRef
  • The effects of rebamipide, sucralfate, and rifaximin against inflammation and apoptosis in radiation-induced murine intestinal injury
    Won Moon, Sangwook Lim, Yeonsoon Jung, Yuk Moon Heo, Seun Ja Park, Moo In Park, Sung Eun Kim, Jae Hyun Kim, Kyoungwon Jung
    Kosin Medical Journal.2022; 37(4): 320.     CrossRef
How to write an original article in medicine and medical science
Gwansuk Kang, Sung Eun Kim
Kosin Med J. 2022;37(2):96-101.   Published online June 24, 2022
DOI: https://doi.org/10.7180/kmj.22.105
  • 845 View
  • 41 Download
  • 2 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Excellent research in the fields of medicine and medical science can advance the field and contribute to human health improvement. In this aspect, research is important. However, if researchers do not publish their research, their efforts cannot benefit anyone. To make a difference, researchers must disseminate their results and communicate their opinions. One way to do this is by publishing their research. Therefore, academic writing is an essential skill for researchers. However, preparing a manuscript is not an easy task, and it is difficult to write well. Following a structure may be helpful for researchers. For example, the standard structure of medical and medical science articles includes the following sections: introduction, methods, results, and discussion (IMRAD). The purpose of this review is to present an introduction for researchers, especially novices, on how to write an original article in the field of medicine and medical science. Therefore, we discuss how to prepare and write a research manuscript for publication, using the IMRAD structure. We also included specific tips for writing manuscripts in medicine and medical science.

Citations

Citations to this article as recorded by  
  • How does quiz activity affect summative assessment outcomes? An analysis of three consecutive years’ data on self-directed learning
    Chi Eun Oh, Hyunyong Hwang
    Kosin Medical Journal.2022; 37(3): 228.     CrossRef
  • The effects of rebamipide, sucralfate, and rifaximin against inflammation and apoptosis in radiation-induced murine intestinal injury
    Won Moon, Sangwook Lim, Yeonsoon Jung, Yuk Moon Heo, Seun Ja Park, Moo In Park, Sung Eun Kim, Jae Hyun Kim, Kyoungwon Jung
    Kosin Medical Journal.2022; 37(4): 320.     CrossRef
The Roles of Human Endogenous Retroviruses (HERVs) in Inflammation
Eun-Ji Ko, Hee-Jae Cha
Kosin Med J. 2021;36(2):69-78.   Published online December 31, 2021
DOI: https://doi.org/10.7180/kmj.2021.36.2.69
  • 886 View
  • 15 Download
  • 2 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM

Human endogenous retroviruses (HERVs) are ancient, currently inactive, and non-infectious due to recombination, deletions, and mutations in the host genome. However, HERV-derived elements are involved in physiological phenomena including inflammatory response. In recent studies, HERV-derived elements were involved directly in various inflammatory diseases including autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis, amyotrophic lateral sclerosis (ALS), and Sjogren’s syndrome. Regarding the involvement of HERV-derived elements in inflammation, two possible mechanisms have been proposed. First, HERV-derived elements cause nonspecific innate immune processes. Second, HERV-derived RNA or proteins might stimulate selective signaling mechanisms. However, it is unknown how silent HERV elements are activated in the inflammatory response and what factors and signaling mechanisms are involved with HERV-derived elements. In this review, we introduce HERV-related autoimmune diseases and propose the possible action mechanisms of HERV-derived elements in the inflammatory response at the molecular level.

Citations

Citations to this article as recorded by  
  • Effect of human endogenous retrovirus-K env gene knockout on proliferation of ovarian cancer cells
    Eun-Ji Ko, Eun Taeg Kim, Heungyeol Kim, Chul Min Lee, Suk Bong Koh, Wan Kyu Eo, Hongbae Kim, Young Lim Oh, Mee Sun Ock, Ki Hyung Kim, Hee-Jae Cha
    Genes & Genomics.2022; 44(9): 1091.     CrossRef
  • A Systems Biology Approach on the Regulatory Footprint of Human Endogenous Retroviruses (HERVs)
    Georgios S. Markopoulos
    Diseases.2022; 10(4): 98.     CrossRef
Original article
Influence of Orthokeratology Lens on Axial length Elongation and Myopic Progression in Childhood Myopia
Su Jin Kim, Ji Eun Lee
Kosin Med J. 2017;32(2):204-211.   Published online December 29, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.2.204
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  • 2 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

To investigate the clinical effects of orthokeratology lens wear on inhibition of the myopic progression and axial length elongation in Korean children with myopia.

Methods

The authors reviewed out-patient records of 37 eyes of 19 patients wearing orthokeratology lenses. The 46 eyes of 23 patients wearing spectacles were included into the control group. We evaluated the relationship between orthokeratology lens wear and control group according to age, initial myopia, initial astigmatism, axial length elongation.

Results

There were no significant differences between two groups as for age, initial myopia, astigmatism, spherical equivalent, and axial length at baseline (t-test, P > 0.05). Significant reduction of refraction was shown in patients with wearing lenses after 1 year (t-test, P < 0.001). The mean axial length before and after 1 year was 24.62 ± 1.39 mm and 24.73 ± 1.28 mm respectively after lens wearing, and 24.59 ± 0.74 mm and 24.80 ± 0.71 mm respectively after wearing glasses. The axial length elongation was 0.11 ± 0.12 mm, and 0.21 ± 0.07 mm in patients with wearing lenses and glasses, respectively, which showed statistically significant difference (t-test, P < 0.0001).

Conclusions

The orthokeratology lens was found to be effective in suppression of myopic progression through less axial length elongation, compared with the glasses.

Citations

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  • Refractive and corneal responses of young myopic children to short-term orthokeratology treatment with different compression factors
    Kin Wan, Jason Ki-kit Lau, Sin Wan Cheung, Pauline Cho
    Contact Lens and Anterior Eye.2020; 43(1): 65.     CrossRef
  • The Impact of Overnight Orthokeratology on Accommodative Response in Myopic Subjects
    Ana F. Pereira-da-Mota, Jéssica Costa, Ana Amorim-de-Sousa, José M. González-Méijome, António Queirós
    Journal of Clinical Medicine.2020; 9(11): 3687.     CrossRef
Case report
Aortic Dissection after Intravenous Thrombolysis in Acute Cerebral Infarction
Young Rok Do
Kosin Med J. 2017;32(1):127-132.   Published online June 30, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.1.127
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Use of recombinant tissue plasminogen activator (rt-PA) for the treatment of acute cerebral infarction secondary to aortic dissection is challenging because of a narrow time window and potential life-threatening complications. An 80-year-old woman with right middle cerebral artery infarction was treated with rt-PA. Although she had no history, symptoms, or sign of aortic dissection, carotid CT angiography revealed aortic arch dissection. Mediastinal widening, which did not show on initial chest X-ray, developed on follow-up chest X-ray. This observation indicates that physicians should monitor patient symptoms for signs of aortic dissection during thrombolysis and perform chest X-ray or carotid angiography immediately after thrombolysis even if the patient has no symptoms or signs of aortic dissection on onset of acute cerebral infarction.

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  • Successful intravenous thrombolysis for acute ischemic stroke caused by aortic dissection with severe hypofibrinogenemia: a case report and literature review
    Liming Cao, Xuming Huang, Fei-qi Zui
    International Journal of Neuroscience.2022; 132(9): 939.     CrossRef
  • Clinical Usefulness of Common Carotid Artery Dissection in Carotid Ultrasound for the Diagnosis of Asymptomatic Aortic Dissection
    Seon-Jae Im, Hyun Young Park
    Journal of the Korean Neurological Association.2020; 38(1): 66.     CrossRef
Original articles
Effect of Rheumatoid Factor on Vascular Stiffness in General Population without Joint Symptoms
Ji Hyun Lee, Hee Sang Tag, Geun Tae Kim, Min Jeong Kim, Seung Geun Lee, Eun Kyung Park, Dong Wa Koo
Kosin Med J. 2017;32(1):25-35.   Published online January 19, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.1.25
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Objectives

The role of rheumatoid factor (RF) in vascular stiffness and cardiovascular risk in subjects without joint symptoms remains unclear. We investigated vascular stiffness in subjects without joint symptoms using pulse wave velocity (PWV), calculated Framingham risk scores (FRS), an estimator of cardiovascular risk, and analyzed whether vascular stiffness and FRS were affected by RF.

Methods

Two hundred forty-two subjects were included in this population-based study. RF was quantified with turbid immunometry using a cut-off of RF > 15 IU/ml to denote RF positivity. Information was then obtained on joint symptoms. Brachial-ankle PWV (baPWV) was measured using an automated device.

Results

Of the 242 subjects, 15 were RF-positive. RF-positive subjects without joint symptoms had a higher baPWV and FRS than RF-negative subjects without joint symptoms, but the difference did not reach statistical significance. However, when we stratified the subjects into two groups (group A – high RF: RF ≥ 40 IU/ml; group B – low RF: RF < 40 IU/ml), group A showed significantly higher baPWV (1640.7 ± 179.6 ㎝/s vs. 1405.7 ± 225.7 ㎝/s, P= 0.008) and FRS (25.7 ± 4.87 vs. 11.8 ± 9.6, P< 0.001). Multiple regression analysis was used to examine potential confounders, and RF exhibited significant but modest effects on baPWV (adjusted R-squared = 0.038, P= 0.030).

Conclusions

In a sample of the general population without joint symptoms, higher levels of RF were associated with increased vascular stiffness, suggesting a pathophysiologic link between RF and endothelial dysfunction.

Citations

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  • Model-Based Design of Defense Cyber-Physical Systems to Analyze Mission Effectiveness and Network Performance
    Bong Gu Kang, Kyung-Min Seo, Tag Gon Kim
    IEEE Access.2019; 7: 42063.     CrossRef
  • Communication Analysis of Network-Centric Warfare via Transformation of System of Systems Model into Integrated System Model Using Neural Network
    Bong Gu Kang, Kyung-Min Seo, Tag Gon Kim
    Complexity.2018; 2018: 1.     CrossRef
A Computer-Assisted, Real-Time Feedback System for Medical Students as a Tool for Web-Based Learning
Hyunyong Hwang
Kosin Med J. 2016;31(2):134-145.   Published online January 20, 2016
DOI: https://doi.org/10.7180/kmj.2016.31.2.134
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Abstract Objectives

Medical students sometimes do not receive proper feedback from their instructors. This study evaluated a newly developed automated and personalized real-time feedback system intended to address this issue.

Methods

Third- and fourth-year medical students participated in quizzes focusing on 17 learning objectives and a five-scale survey that queried their prior knowledge related to blood transfusions. Immediately after completing the quizzes, the students received automated and personalized, real-time feedback and were instructed to take part in self-directed learning. This activity was followed by a final quiz. After completion of the final quiz, the students responded to the five-scale survey that probed the usefulness of and satisfaction with the automated, personalized, real-time feedback system.

Results

Eighty students took part in this study. The third-year group had a higher score for prior knowledge and also on the first quiz (P= 0.008, P= 0.046, respectively). There was no significant difference in final quiz scores between the third- and fourth-year groups (P= 0.633). The scores for usefulness of and satisfaction with the automated, real-time feedback system were 4.45 and 4.34, and 4.55 and 4.40 in the third- and fourth-year students, respectively.

Conclusions

The automated, personalized, real-time feedback system provided timely and effective feedback for medical students and was helpful for their self-directed learning.

Citations

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  • New approach to learning medical procedures using a smartphone and the Moodle platform to facilitate assessments and written feedback
    Sang-Shin Lee, Haeyoung Lee, Hyunyong Hwang
    Kosin Medical Journal.2022; 37(1): 75.     CrossRef
  • How does quiz activity affect summative assessment outcomes? An analysis of three consecutive years’ data on self-directed learning
    Chi Eun Oh, Hyunyong Hwang
    Kosin Medical Journal.2022; 37(3): 228.     CrossRef
Review article
Women, Stress and Heart Health: Mindfulness-Based Stress Reduction and Cardiovascular Disease
Kyoung-Im Cho
Kosin Med J. 2016;31(2):103-112.   Published online January 20, 2016
DOI: https://doi.org/10.7180/kmj.2016.31.2.103
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Abstract

Psychological stress including depression and anxiety are independent risk factors for cardiovascular disease morbidity and mortality, especially in women. Emotional regulation plays a mediating role in the development of depression and physical illness, and can alter resting physiologic responses associated with the stress response. Mindfulness-based stress reduction (MBSR) is a structured group program that employs mindfulness meditation to alleviate suffering associated with physical, psychosomatic, and psychiatric disorders. MBSR was originally developed for the management of chronic pain, which is now used widely to reduce psychological morbidity associated with chronic illnesses and to treat emotional and behavioral disorders. In cardiovascular disease, MBSR may be helpful for controlling several risk factors for coronary heart disease such as hypertension, type 2 diabetes mellitus, dyslipidemia, oxidative and psychosocial stress, obesity, and smoking, and improvements in submaximal exercise responses and heart rate variability. Although the most effective mode of stress reduction therapy is yet to be established, increasing recognition is being given to MBSR therapy.

Citations

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  • Psychosomatic Approach to Fibromyalgia Syndrome: Concept, Diagnosis and Treatment
    Sang-Shin Lee
    Kosin Medical Journal.2021; 36(2): 79.     CrossRef
  • Investigating the effect of meditation on spiritual wellbeing of Type-2 diabetic amputees: A clinical trial study
    Ali Heydari Movahed, Fakhri Sabouhi, Reza Mohammadpourhodki, Sepideh Mahdavi, Sima Goudarzian, Malihe Amerian, Mona Mohtashami, Mansoure Kheiri, Malihe Imeni
    Heliyon.2020; 6(11): e05567.     CrossRef
Case report
A Case of Disseminated Extranodal Interdigitating Dendritic Cell Sarcoma Arising from Parotid Gland
Young Hoon Park, Shin Il Kim, Suk Jin Choi, Joo Han Lim, Hyeon Gyu Yi, Moon Hee Lee, Chul Soo Kim
Kosin Med J. 2015;30(2):163-169.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.2.163
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Abstract

Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare tumor derived from professional antigen presenting cell and primarily found in lymph nodes, with rarer case report about extranodal presentation of IDCS. A 71-yr-old man was admitted with progressively enlarging and painless mass in the right parotid area for 2 months. Computed tomography of the neck and chest revealed enhancing mass in right parotid gland, multiple lymphadenopathies around neck and mediastinum, and an osteolytic metastasis at thoracic spine. Morphological and immunohistochemical analysis of an excisional biopsy specimen from parotid mass were consistent with a diagnosis of IDCS. Palliative chemotherapy with 6 cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) regimen and 2 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) regimen plus radiotherapy on parotid mass failed in tumor reduction. We describe a rare case of disseminated extranodal IDCS arising from parotid gland.

Citations

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  • Interdigitating dendritic cell sarcoma involving head and neck region- a report of four cases with review of literature
    Archana Lakshmanan, Ann Kurian, S. Annapurneswari
    Human Pathology: Case Reports.2021; 24: 200514.     CrossRef
  • New insights inside the interdigitating dendritic cell sarcoma—pooled analysis and review of literature
    Amr Muhammed, Ahmed R. H. Ahmed, Hashem Maysa, Ahmed E. S. Mohamed, Asmaa Abd-ElGhany Abd-ElLateef, Esraa Elnakib
    Annals of Hematology.2019; 98(12): 2641.     CrossRef

KMJ : Kosin Medical Journal