Kosin Medical Journal

Yun Kyu Oh

1 Article

Are you ready to accompany autosomal dominant polycystic kidney disease patients in their treatment journey? Real practice for selecting rapid progressors and treatment with tolvaptan: Yeonsoon Jung, Yun Kyu Oh; Kosin Med J. 2023;38(2):87-97. Published online June 28, 2023; DOI: https://doi.org/10.7180/kmj.23.125

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Tolvaptan treatment is costly, often accompanied by aquaresis-related adverse events, and requires careful monitoring by medical staff due to the possibility of hepatotoxicity. Nevertheless, it is the only disease-modifying drug to date that has been shown to successfully delay renal replacement therapy. For more patients to receive proper treatment, medical doctors, the rest of the medical team, and the patient must all work together. This paper reviews parameters that can help identify rapid autosomal dominant polycystic kidney disease progressors, who are the target of tolvaptan therapy. It is expected that these parameters will help nephrologists learn practical prescription methods and identify patients who can benefit from tolvaptan treatment. Although several strategies can be used to find rapid progressors, the present review focuses on a practical method to identify rapid progressors according to the presence or absence of evidence and the factors associated with rapid progression based on the Mayo image classification.

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Evaluating physician confidence and barriers in prescribing tolvaptan for ADPKD management: a comprehensive online survey study
Niloufar Ebrahimi, Mehrbod Vakhshoori, Fouad Chebib, Pranav S. Garimella, Yasar Caliskan, Amir Abdipour, Sayna Norouzi
Journal of Nephrology.2024;[Epub] CrossRef

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