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Young Shin Shin 1 Article
A Case of Seizure and Metabolic Acidosis Due to Renal Adjustment Dosage of Isoniazid in an Elderly Woman
Young Shin Shin, Eun Hee Sim, Chang Woo Yeo, Jin Doo Kang, Ji Yeon Kim, Seon Ja Park
Kosin Med J. 2014;29(1):63-68.   Published online December 17, 2014
DOI: https://doi.org/10.7180/kmj.2014.29.1.63
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Abstract

Isoniazid is one of the most commonly used antituberculosis drug. Acute into xication is characterized by repetitious convulsions, high anion gap metabolic a cidosis and coma. The basis of theraphy consists of parental pyridoxine admi nistration in a dose equivalent to that of isoniazid ingested. Here we present a case of seizure and metabolic acidosis due to only renal adjustment dosage of Isoniazid in an elderly woman.


KMJ : Kosin Medical Journal