- Analysis of ultradian rest-activity rhythms using locomotor activity in mice
-
Jung Hyun Lee, Eunsoo Moon, Jeonghyun Park, Yoo Rha Hong, Min Yoon
-
Kosin Med J. 2022;37(2):127-133. Published online June 24, 2022
-
DOI: https://doi.org/10.7180/kmj.22.023
-
-
 Abstract
 PDF PubReader  ePub  Crossref - TDM
- Background
Locomotor activity in mice may have an ultradian rest-activity rhythm. However, to date, no study has shown how locomotor activity can be explained statistically using fitted cosine curves. Therefore, this study explored whether the ultradian rhythm of locomotor activity in mice could be analyzed using cosine fitting analysis.
Methods
The locomotor activity of 20 male mice under a 12/12-hour dark/light cycle for 2 days was fitted to a cosine function to obtain the best fit. The mean absolute error (MAE) values were used to determine the explanatory power of the calculated cosine model for locomotor activity. The cosine fitting analysis was performed using R statistical software (version 4.1.1).
Results
The mean MAE was 0.2944, whereas the mean MAE for integrating the individual analyses in the two experimental groups was 0.3284. The periods of the estimated ultradian rest-activity rhythm ranged from 1.602 to 4.168 hours.
Conclusions
These results suggest that locomotor activity data reflect an ultradian rhythm better than a circadian rhythm. Locomotor activity can be statistically fitted to a cosine curve under well-controlled conditions. In the future, it will be necessary to explore whether this cosine-fitting analysis can be used to analyze ultradian rhythms under different experimental conditions.
- Performance comparison between Elecsys Anti-SARS-CoV-2 and Anti-SARS-CoV-2 S and Atellica IM SARS-CoV-2 Total and SARS-CoV-2 IgG assays
-
Seri Jeong, Yoo Rha Hong, Hyunyong Hwang
-
Kosin Med J. 2022;37(2):154-162. Published online June 27, 2022
-
DOI: https://doi.org/10.7180/kmj.22.114
-
-
1,438
View
-
36
Download
-
1
Citations
-
Abstract
PDFPubReader Crossref - TDM
- Background
Although serological severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests from several manufacturers have been introduced in South Korea and some are commercially available, the performance of these test kits has not yet been sufficiently validated. Therefore, we compared the performance of Elecsys Anti-SARS-CoV-2 (ACOV2) and Anti-SARS-CoV-2 S (ACOV2S) and Atellica IM SARS-CoV-2 Total (COV2T) and SARS-CoV-2 IgG (sCOVG) serological tests in this study.
Methods
A total of 186 patient samples were used. For each test, we analyzed the positive rate of serological antibody tests, precision, linearity, and agreement among the four assays.
Results
The positive rates of COV2T, sCOVG, and ACOV2S were high (81.7%–89.2%) in total, with those for ACOV2S being the highest, while those of ACOV2 were as low as 44.6%. This may be related to the high completion rate of vaccination in Korea. The repeatability and within-laboratory coefficients of variation were within the claimed allowable imprecision; however, further research is needed to establish an allowable imprecision at low concentrations. COV2T showed a linear fit, whereas sCOVG and ACOV2S were appropriately modeled with a nonlinear fit. Good agreement was found among COV2T, sCOVG, and ACOV2S; however, the agreement between ACOV2 and any one of the other methods was poor.
Conclusions
Considering the different antigens used in serological SARS-CoV-2 antibody assays, the performance of the tested assays is thought to show no significant difference for the qualitative detection of antibodies to SARS-CoV-2.
-
Citations
Citations to this article as recorded by  - Evaluation of automated calibration and quality control processes using the Aptio total laboratory automation system
Namhee Kim, Yein Kim, Jeongeun Park, Jungsoo Choi, Hyunyong Hwang
Kosin Medical Journal.2022; 37(4): 342. CrossRef
- Clinical Features and Factors Associated with the Frequency of Phototherapy in Premature Birth Gestation < 35 Weeks and Birth Weight ≤2,500 g
-
So Yoon Choi, Ho Yeon Hwang, Yoo Rha Hong, Yu Jin Jung
-
Kosin Med J. 2012;27(2):133-139. Published online December 27, 2012
-
DOI: https://doi.org/10.7180/kmj.2012.27.2.133
-
-
Abstract
PDFPubReader ePub Crossref - TDM
-
Objectives
Clinical features according to the frequency of phototherapy and clinical risk factors on the number of phototherapy were investigated in premature births with gestation <35 weeks and birth weight ≤2,500 g.
Methods
The 186 infants with gestation <35 weeks and birth weight ≤2,500 g were admitted to the neonatal intensive care unit of Kosin University Gospel Hospital from March 2009 to August 2010. The 171 infants were alive and had jaundice requiring phototherapy. Phototherapy was usually started to 50-70% of the maximal bilirubin level. They were divided into two groups according to the frequency of phototherapy as single phototherapy group (group I) and multiple phototherapy group (group II). We retrospectively reviewed the medical records of all patients.
Results
The mean gestational age and birth weight of group I were 31.0±2.9 weeks and 1,596±485 g and those of group II were 31.1±2.6 weeks and 1,592±430 g. Compared with group I, albumin and Apgar score at 1 minute of group II were significantly higher and the day of peak bilirubin was also late. Duration of phototherapy in group II was statistically longer than that group I but duration of ventilator and aminophylline use for apnea was significantly shorter. The frequency of antibiotic use, incidence of bronchopulmonary dysplasia (BPD), and intraventricular hemorrhage (IVH) of group II were significantly lower than those of group I.
Conclusions
The day of peak bilirubin was late and the frequency of antibiotic use, incidence of BPD, and IVH were low in group II. The aggressive phototherapy may be considered in premature births with jaundice.
- Emotional and Behavioral Problems Based on Parent Reported Problem Checklist in Primary School Children
-
Soon Yoe, Yoo Rha Hong, Jae Sun Park, Yong Hwan Lee, Min Hyang Kim
-
Kosin Med J. 2007;22(2):71-82. Published online December 31, 2007
-
-
-
PDF
- A Case of Prader-Willi Syndrome with Hypotonia and Cryptorchidism Diagnosed at Neonate
-
Soon Yoe, Jung Hyun Lee, Yoo Rha Hong
-
Kosin Med J. 2007;22(2):186-190. Published online December 31, 2007
-
-
-
PDF
- Treatment of ulcerated perineal hemangioma in extremely low birth weight infant
-
Yoo Rha Hong
-
Kosin Med J. 2007;22(2):199-204. Published online December 31, 2007
-
-
-
PDF
- Leukemia cutis with congenital acute myeloid leukemia
-
Yoo Rha Hong, Mi Hyang Kim
-
Kosin Med J. 2007;22(2):205-209. Published online December 31, 2007
-
-
-
PDF
- High Dose Ara-C Based Chemotherapy in the Children with Acute Myelocytic Leukemia
-
Yoo Rha Hong, Bo Young Lee, Jung Hyun Lee, Ji Hae Kang, Jae Sun Park, Mi Hyang Kim
-
Kosin Med J. 2004;19(1):1-8.
-
-
-
PDF
|
KOSIN UNIVERSITY COLLEGE OF MEDICINE
