- Retrospective analysis on the clinical efficacy of bevacizumab combined with FOLFOX4 in the first line treatment of metastatic colorectal cancer
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Eun Mi Lee, Lee Chun Park, Ho Sup Lee, Seong Hoon Shin, Yang Soo Kim
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Kosin Med J. 2017;32(2):170-178. Published online January 19, 2017
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DOI: https://doi.org/10.7180/kmj.2017.32.2.170
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Abstract
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- Objectives
The addition of bevacizumab to standard chemotherapy has been improved survival outcomes in patients with metastatic colorectal cancer. However, the combination of bevacizumab with oxaliplatin-based chemotherapy as first-line treatment showed limited survival benefit. The purpose of this study was to investigate the clinical efficacy and toxicity of the combination of bevacizumab to oxaliplatin and leucovorin (FOLFOX4) in the first-line treatment of patient with metastatic colorectal cancer.
MethodsBetween December 2004 and September 2009, medical records of patients who were diagnosed with metastatic colorectal cancer and received the first line chemotherapy with bevacizumab and FOLFOX4, were retrospectively reviewed.
ResultsA total of forty patients were analyzed. The median age of the patients was 55 years (range, 33-80), and 55% was male. The patients received a total of 206 cycles of therapy (median 4 cycles per patient; range 1 – 15 cycles). Of these 40 patients, none achieved complete response (CR) and 15 achieved a partial response (PR), for the overall response rate (ORR) 37.5% (95% CI, 22.5-52.5). Median progression free survival (PFS) was 6.9 months (95% CI, 3.4-10.5) and median overall survival (OS) was 22.6 months (95% CI, 17.3-27.8The most common grade 3 or 4 hematologic toxicity and non-hematologic toxicity were neutropenia (10.0%) and diarrhea (10.0%), respectively. Two patients experienced gastrointestinal perforation.
ConclusionsIn this study, the combination bevacizumab with FOLFOX4 was associated with favorable OS, but did not showed favorable PFS and ORR.
- Prognostic Significance of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Diffuse Large B-Cell Lymphoma Patients Treated with R-CHOP
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Lee Chun Park, Ho Sup Lee, Eun Mi Lee, Seong Hoon Shin, Yang Soo Kim
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Kosin Med J. 2016;31(2):122-133. Published online January 20, 2016
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DOI: https://doi.org/10.7180/kmj.2016.31.2.122
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Abstract
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- Abstract
Objectives
The both values of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) were reported as indexes of systemic inflammation and readily available and inexpensive prognostic markers in patients with solid cancer. The objective of this study was to clarify whether the NLR and PLR were significant prognostic markers in Korean diffuse large B-cell lymphoma (DLBCL) patients treated with R-CHOP as a first line therapy.
Methods
: We retrospectively collected the clinical data of ninety nine DLBCL patients treated with R-CHOP from 2004 to 2012 and analyzed. NLR and PLR were calculated from complete blood count (CBC) and differential leukocyte count.
Results
: In univariate analysis, NLR was significantly associated with 5-year progression free survival(PFS) rate (P= 0.039), but not significantly associated with 5-year overal survival (OS) rate (P= 0.276). PLR was not significantly associated with 5-year PFS (P= 0.632) and OS rate (P= 0.855). In multivariate analysis, NLR was not a significant independent prognostic factor for 5-year PFS (P= 0.415) and OS rate (P= 0.991).
Conclusion
: The NLR can be considered a useful predictor of survival outcome. The PLR is not a valid predictor of survival outcome.
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Citations
Citations to this article as recorded by
- Prognostic Role of Neutrophil to Lymphocyte Ratio at Diagnosis in Patients with Diffuse Large B-Cell Lymphoma
G Korkmaz, F Ceran, S Dağdaş, AK Güneş, C Sunu, MS Pepeler, M Pamukçuoğlu, G Özet Nigerian Journal of Clinical Practice.2024; 27(8): 1012. CrossRef - Prognostic role of neutrophil-to-lymphocyte ratio in diffuse large B cell lymphoma patients: an updated dose–response meta-analysis
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- Herpesviridae Viral Infections Following Stem Cell Transplantation in Hematologic Malignancy
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Ho Sup Lee, Hee Sang Tag, Seong Hoon Shin, Yang Soo Kim, Sung Jin Nam, Hye Soo Kim, Jin Hee Park, Su Hyeon Jeong, Sung Bin Kim, Ye Na Kim
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Kosin Med J. 2010;25(1):20-26. Published online June 30, 2010
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- Cytotoxic Effect of Ganoderma Lucidum to Peripheral Blood Cells
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Yang Soo Kim
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Kosin Med J. 2008;23(4):20-26. Published online December 31, 2008
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- 4 Cases of Extramedullary Plasmacytomas Treated with Bortezomib and Dexamethasone
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Jong Hyun Paek, Eun Young Lee, Ri Ra Jang, Chang Bae Sohn, Eun Kyung Shin, Jeong Ah Seo, Jee Suk Lee, Ho Seop Lee, Sang Min Lee, Seong Hoon Shin, Yang Soo Kim
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Kosin Med J. 2007;22(2):216-220. Published online December 31, 2007
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- Apoptosis by Cyanate in Kidney Mesangial Cell
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Ji Yeol Kim, Yang Soo Kim, Ki Yeon Hong, Wan Kyu Eo, Young Sik Choi
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Kosin Med J. 2007;22(1):160-169. Published online June 30, 2007
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- The Relationship Between Initial Biochemical Bone Markers and Change of Bone Mineral Density in Post Menopausal Women with Hormone Therapy
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Chi Heui Cho, Eun Hee Kong, Young Sik Choi, Yang Soo Kim, Heung Yeol Kim, Wan Kyu Eo, Ki Yeon Hong
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Kosin Med J. 2007;22(1):212-219. Published online June 30, 2007
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- The Effect of Apoptosis Related Protein Expression by Cyclosporine in Osteoblast
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Young Lim Oh, Wan Kyu Eo, Ki Yeon Hong, Yang Soo Kim, Heung Yeol Kim
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Kosin Med J. 2007;22(1):232-239. Published online June 30, 2007
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- Change of NK cell activity in case of iron deficiency anemia adult patients
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Su Hong Kim, Jeoung Hoon Seo, Yang Soo Kim, Wan Gyu Eo
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Kosin Med J. 2005;20(1):49-56.
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- A Case of Primary Plasma Cell Leukemia with Atypical Morphology
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Byoung Joo Choi, Su Hong Seo, Seong Hoon Chang, Yang Soo Kim, Wan Kyu Eo, Hyo Kyoung Kim
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Kosin Med J. 2002;17(1):161-165.
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- A case of POEMS syndrome
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Soo Hong Seo, Byoung Joo Choi, Chee Whan No, Chae Hee Shin, Seong Hoon Chang, Yang Soo Kim, Wan Kyu Eo, Hyo Kyoung Kim
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Kosin Med J. 2002;17(1):152-156.
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