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Taek Sang Kim 10 Articles
Comparative study of off-clamp, laparoscopic partial nephrectomy (OCLPN) and conventional hilar control, laparoscopic partial nephrectomy (HCLPN) for renal tumors: One-year follow-up results of renal function change
Su Hwan Kang, Hyun Yul Rhew, Taek Sang Kim
Kosin Med J. 2018;33(2):191-199.   Published online December 31, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.2.191
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

We designed the study to compare the oncologic and renal function outcomes of off-clamp, laparoscopic partial nephrectomy (OCLPN) and conventional laparoscopic partial nephrectomy (HCLPN) for renal tumors.

Methods

Between March 2008 and July 2015, 114 patients who underwent laparoscopic partial nephrectomy (LPN) of a renal neoplasm were studied. We performed LPN without hilar clamp on 40 patients (OCLPN, Group 1), and conventional LPN with hilar control and renorrhaphy on another 40 patients (HCLPN, Group 2). We retrospectively reviewed the medical records of each patient's age, sex, R.E.N.A.L. nephrometry score (RNS), operation time, complications, hospitalization period, tumor size, positive resection margin, histologic classification of tumor, pathologic stage, Fuhrman grade, estimated blood loss (EBL), warm ischemic time (WIT), and estimated glomerular filtration rate (eGFR) before and one year after surgery.

Results

There were no significant differences in age, sex, preoperative eGFR, EBL, surgical (anesthesia) time, and tumor size between the two groups. The mean eGFR was not significantly different between the OCLPN and HCLPN groups 1 month (95 and 86.2 mL/min/1.73 m2, respectively; P = 0.106), 6 months (92.9 and 83.6 mL/min/1.73 m2, respectively; P = 0.151) and 12 months (93.8 and 84.7 mL/min/1.73 m2, respectively; P = 0.077) postoperatively. The change in eGFR after one year was 3.9% in the OCLPN group and −7.9% in the HCLPN group.

Conclusions

OCLPN was superior to HCLPN in preserving renal function one year after surgery, and there was no statistically significant difference in tumor treatment results.

Clinical significance of serum neutrophil gelatinase-associated lipocalin in the early diagnosis of renal function deterioration after radical nephrectomy
Taek Sang Kim, Su Hwan Kang, Pil Moon Kang, Hongkoo Ha, Su Dong Kim, Jangho Yoon, Hyunyong Hwang
Kosin Med J. 2018;33(1):20-28.   Published online January 21, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.1.20
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Abstract PDFPubReader   CrossRef-TDMCrossref - TDM
Objectives

The standard metrics used to monitor the progression of acute kidney injury (AKI) include markers such as serum creatinine, blood urea nitrogen, and estimated glomerular filtration rate (eGFR). Moreover, neutrophil gelatinase-associated lipocalin (NGAL) expression has been reported to modulate oxidative stress.

Methods

We aimed to evaluate the usefulness of serum NGAL levels for monitoring renal function after radical nephrectomy (RN). We prospectively collected data from 30 patients who underwent RN. We analyzed serum NGAL and creatinine at 6 time points: preoperative day 1, right after surgery, 6 hours after surgery, postoperative day (POD) 1, POD 3, and POD 5. We compared these measurements according to the eGFR values (classified as chronic kidney disease stage III; CKD III or not) using data obtained 3 months after surgery.

Results

The mean age was 65.5 years (range, 45–77 years), and the male-to-female ratio was 2:1. At the last follow-up examination, there were 12 patients (40%) with CKD III. Using receiver operating characteristic analysis, we found that serum creatinine on POD 5 (area under the curve [AUC], 0.887; P = 0.000) and NGAL at 6 hours after LRN (AUC, 0.743, P = 0.026) were significant predictors of CKD III. The development of CKD III after LRN was associated with the serum creatinine level on POD 5 and the NGAL at 6 hours after surgery.

Conclusions

Compared to serum creatinine, serum NGAL enabled earlier prediction of postoperative CKD III. Therefore, serum NGAL measured 6 hours after surgery could be a useful marker for managing patients after RN.

Metachronous anterior urethral metastasis of prostatic ductal adenocarcinoma
Jeong Hyun Oh, Taek Sang Kim, Hyun Yul Rhew, Bong Kwon Chun
Kosin Med J. 2016;31(1):66-70.   Published online February 4, 2016
DOI: https://doi.org/10.7180/kmj.2016.31.1.66
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Abstract

Prostate cancer is increasing in frequency in Korea. Among them, ductal adenocarcinoma (DCP) has a more aggressive and poor prognosis than acinar adenocarcinoma (ACP), despite its low incidence. Patients usually present with symptoms of lower urinary tract symptoms and hematuria due to increasing tumor mass within the lumen of the prostatic urethra, making diagnosis of DCP by the transrectal prostate biopsy difficult. DCP is often metastasized at the time of diagnosis. DCP is transferable to most other organs but the metastasis to the anterior urethra is rare. There is no doubt that localized DCP requires radical prostatectomy (RP) but the guidelines for adjuvant therapy after RP have not yet been established. Methods of the treatment are confounded by individual differences, and arriving at a consensus is challenging due to insufficient data. We report a case of DCP and urethral metastasis after RP, thus aiding in the determination of treatment guidelines.

Current Status of Laparoscopic Partial Nephrectomy
Taek Sang Kim
Kosin Med J. 2013;28(2):79-86.   Published online January 19, 2013
DOI: https://doi.org/10.7180/kmj.2013.28.2.79
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM

Recently, nephron-sparing, minimally invasive surgery of small renal masses has become popular. The most typical surgery is laparoscopic partial nephrectomy (LPN). However, due to technical difficulties, the indications for LPN had been limited to small, exophytic, and peripheral tumors. This paper introduces current status of oncological outcomes and technical considerations.

Carbon Monoxide Prevents Ob-Rb Transfected Neuronal Cells from ER Stress-Induced Leption Resistance
Seong Ju Kim, Taek Sang Kim, Hyun Yul Rhew, Hun Taeg Chung
Kosin Med J. 2010;25(1):42-50.   Published online June 30, 2010
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Update of Targeted Molecular Therapy in Metastatic Renal Cell Carcinoma
Taek Sang Kim, Hyun Yul Rhew
Kosin Med J. 2009;24(1):110-118.   Published online June 30, 2009
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Therapeutical Value of Adrenalectomy in case of Metastatic Spead Originating from Primary Renal Cell Solitary Carcinoma
Han Seok Kim, Taek Sang Kim, Hyun Yul Rhew
Kosin Med J. 2007;22(1):184-189.   Published online June 30, 2007
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The Effect of Alfuzosin, Doxazosin, Tamsulosin and Finasteride Combination Therapy in Patients with Benign Prostatic Hyperplasia
Du Yong Kim, Han Seok Kim, Taek Sang Kim, Seong Choi, Hyun Yul Rhew
Kosin Med J. 2007;22(1):190-195.   Published online June 30, 2007
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Regulatory Mechanisms for the Expression of Inducible Nitric Oxide Synthase (iNOS) Gene in Rat Vascular Smooth Muscle Cells
Ho Jun An, Taek Sang Kim, Ju Seok Kang, Hyun Yul Rhew, Hun Taeg Chung
Kosin Med J. 2005;20(1):12-131.
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KMJ : Kosin Medical Journal