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Tae Hwa Lee 10 Articles
Genipin Inhibits Hypoxia-Induced Accumulation of HIF-1α and VEGF Expressions in Human Cervical Carcinoma Cells
Cho Eui Jin, Jung Hyun Lee, Geun Joo Kim, Tae Hwa Lee
Kosin Med J. 2019;34(2):106-116.   Published online December 31, 2019
DOI: https://doi.org/10.7180/kmj.2019.34.2.106
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

Hypoxia—a characteristic of almost all types of solid tumors—has been associated with poor outcomes in several human malignancies. Genipin—an active constituent of Gardenia fruit— has been reported to exert an anti-tumor effect in several cancers. In this study, we investigated inhibition of angiogenesis using Genipin-mediated hypoxia-induced hypoxia inducible factor (HIF-1) and VEGF expression in human cervical cancer cells.

Methods

Under normoxic and hypoxic conditions, the expression of HIF-1α and VEGF in cervical cancer HeLa cells was detected by quantitative reverse transcription polymerase chain reaction and western blotting. Luciferase reporter assays were used to investigate the molecular mechanisms underlying the hypoxia-induced survivin activation.

Results

Surprisingly, we found that Genipin suppressed the HIF-1α accumulation during hypoxia in human liver cancer cell line (HepG2), human prostate cancer cell line (LNCaP), colon cancer cell line (HCT116), and breast cancer cell line (MDA231). Genipin treatment also significantly reduced hypoxia-induced secretion of VEGF.

Conclusions

Suppression of HIF-1α accumulation following treatment with Genipin under hypoxia was associated with PI3K and MAPK pathways. Taken together, these results suggested that Genipin inhibits HIF-1α expression through inhibition of PI3K and MAPK signaling pathways. These results provide new insights into a potential mechanism of the anticancer properties of Genipin.

Citations

Citations to this article as recorded by  
  • Novel Findings regarding the Bioactivity of the Natural Blue Pigment Genipin in Human Diseases
    Magdalena Bryś, Karina Urbańska, Beata Olas
    International Journal of Molecular Sciences.2022; 23(2): 902.     CrossRef
  • The Effects of Natural and Synthetic Blue Dyes on Human Health: A Review of Current Knowledge and Therapeutic Perspectives
    Beata Olas, Jacek Białecki, Karina Urbańska, Magdalena Bryś
    Advances in Nutrition.2021; 12(6): 2301.     CrossRef
  • Polyphenols Extracted from Chinese Hickory (Carya cathayensis) Promote Apoptosis and Inhibit Proliferation through the p53-Dependent Intrinsic and HIF-1α-VEGF Pathways in Ovarian Cancer Cells
    Zhiping He, Shaozhen Wu, Ju Lin, Ashley Booth, Gary O’Neal Rankin, Ivan Martinez, Yi Charlie Chen
    Applied Sciences.2020; 10(23): 8615.     CrossRef
Active Tuberculosis Occurred in Rheumatoid Arthritis Patient Who is Treated with Etanercept after Antituberculosis Chemoprophylaxis with Rifampin
Hae Won Lee, Tae Hwa Lee, Geun-Tae Kim
Kosin Med J. 2010;25(2):203-207.   Published online December 31, 2010
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Clinical Significance of HPV DNA Test for Follow up of Patients with Cervical Intraepithelial Neoplasm After LEETZ
Mi Hyang Kim, Tae Hwa Lee, Young Lim Oh, Chun Jun Lee, Won Gyu Kim
Kosin Med J. 2009;24(2):141-146.   Published online December 31, 2009
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A Case of Misplaced IUD
Tae Hwa Lee, Sung Han Kim
Kosin Med J. 2008;23(4):294-296.   Published online December 31, 2008
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Clinical Characteristics of Clear Cell Carcinoma of The Ovary
Tae Hwa Lee
Kosin Med J. 2008;23(2):52-57.   Published online June 30, 2008
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A Clinical Study of Borderline Malignant Tumors of the Ovary
Tae Hwa Lee, Sung Han Kim
Kosin Med J. 2008;23(2):58-65.   Published online June 30, 2008
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Lifetime and Age Conditional Probabilities of Reproductive Organ cancers in Women of Korea
Min Jung Kim, Tae Hwa Lee, Sung Han Kim
Kosin Med J. 2007;22(2):89-99.   Published online December 31, 2007
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A Case of Delivery in Severe Gestational Thrombocytopenia
Tae Hwa Lee, Chun June Lee
Kosin Med J. 2007;22(2):195-198.   Published online December 31, 2007
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A Case of Gate Disturbance after Separation of the Symphysis Pubis during Labor
Tae Hwa Lee, chun june lee
Kosin Med J. 2006;21(2):162-165.
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A Case of Primary Signet Ring Cell Adenocarcinoma of Uterine Cervix
Tae Hwa Lee, chun june lee, Sung Han Kim
Kosin Med J. 2006;21(2):166-169.
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KMJ : Kosin Medical Journal