- Current understanding of modulated electro-hyperthermia in cancer treatment
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Sungmin Kim, Jesang Yu, Jihun Kang, Yunkyung Kim, Taek Yong Ko
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Kosin Med J. 2024;39(3):160-168. Published online September 23, 2024
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DOI: https://doi.org/10.7180/kmj.24.127
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 Abstract
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- Traditional hyperthermia involves increasing the temperature at the tumor site to above 39 ℃, inducing death in cancer cells. Although hyperthermia is an effective cancer treatment, its clinical application has decreased due to potential complications, including damage to surrounding normal tissue. In recent years, modulated electro-hyperthermia (mEHT) has emerged as an effective and safe treatment modality. mEHT selectively heats tumor cells to 42–43 °C, while reducing the average temperature in the treatment area, including the surrounding normal tissue, compared to conventional methods. Additionally, mEHT may be used in combination with systemic chemotherapy and radiation therapy in tumor treatment, providing a synergistic effect to increase efficacy. As chemotherapy and radiation therapy technologies advance, the application of combined mEHT may improve clinical outcomes. In this study, we review and discuss reports on the clinical outcomes of mEHT combined with chemotherapy and/or radiation therapy, which are established anticancer treatments.
- IgG4-Related Disease with lymphadenopathy Presenting as a Cervical lymph node enlargement
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Yeon Seok Choi, SungMin Kim, Jang Sihn Sohn, JiYong Hwang, TaeSoo Chang, Do Yeon Cho
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Kosin Med J. 2017;32(2):233-239. Published online December 29, 2017
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DOI: https://doi.org/10.7180/kmj.2017.32.2.233
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Abstract
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During the course of evaluation and management of neck masses, consideration for Immunoglobulin G4-related disease (IgG4-RD) should be given. IgG4-RD is relatively a new growing entity of immune-mediated origin, characterized by a mass-forming lesion, the infiltration of IgG4-positive plasma cells and occasionally elevated serum IgG4. The most common manifestations are parotid and lacrimal swelling, lymphadenopathy and autoimmune pancreatitis.
A previously healthy 72-year-old man was referred to our clinic with a 2-month history of left cervical lymph node enlargement without systemic manifestations . A cervical lymph node biopsy was planned because of elevated serum IgG4 levels. Pathological findings showed prominent infiltration of IgG4-postive plasma cells in the lymph node. After steroid therapy, a computed tomography scan revealed a decrease in the cervical lymph node size.
This case illustrates the importance of including IgG4-RD in the differential diagnosis of a cervical lymph node enlargement.
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KOSIN UNIVERSITY COLLEGE OF MEDICINE
