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Sung Wook Chun 2 Articles
Spontaneous uterine rupture due to placenta percreta in the second trimester of pregnancy: a case report
So Young Seo, Dong Wook Kim, Bo Mi Kim, Sung Wook Chun
Kosin Med J. 2017;32(2):263-268.   Published online December 29, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.2.263
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM

A 32-year-old multiparous woman (gravida 2, para 2) with a history of previous cesarean section had acute abdominal pain and collapsed at 21 weeks of gestation. Exploratory laparotomy was performed because of the patient's worsening condition; ultrasound examination results were suggestive of massive hemoperitoneum, and fetus in vertex presentation with bradycardia. Uterine rupture between the left lower segment and borderline of the cervix in the anterior wall with active bleeding was confirmed. An uncomplicated classical cesarean section was performed, but the fetus was stillborn due to preterm birth. Hysterectomy was performed after the cesarean section. The patient was admitted to intensive care units for 3 days and was discharged in 12 days following delivery. Placenta percreta at the anterior lower segment of the uterus was confirmed in the pathology report.

An Overview of the Clinical Efficacy and Safety of Tissue Selective Estrogen Complex: From the Selective Estrogens, Menopause, and Response to Therapy (SMART) Trials
Sung Wook Chun
Kosin Med J. 2017;32(1):5-16.   Published online June 30, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.1.5
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM

Hormone therapy (HT) is the most effective treatment for menopausal symptoms, and reduces both spinal and non-spinal postmenopausal osteoporotic fractures. However, a Women's Health Initiative (WHI) trial revealed that progestin-containing HT is associated with higher incidences of breast cancer and coronary heart disease than those associated with placebo. Tissue selective estrogen complex (TSEC) is a novel progestin-free HT option composed of conjugated estrogens (CE) and a selective estrogen receptor modulator. CE at a dose of 0.45 mg combined with 20 mg of bazedoxifene was the first TSEC medication approved in the United States and Korea for women with moderate to severe menopause-related vasomotor symptoms (VMS) and for preventing postmenopausal osteoporosis. This review summarizes the clinical efficacy, safety, and tolerability of TSEC as obtained from the five SMART clinical trials.


KMJ : Kosin Medical Journal