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Sun Young Ma 3 Articles
Effects of L-ascorbic acid on the production of pro-inflammatory and anti-inflammatory cytokines in C57BL/6 mouse splenocytes
Eun Hee Kong, Sun Young Ma, Jee Yeong Jeong, Kwang Hyuk Kim
Kosin Med J. 2015;30(1):41-49.   Published online January 20, 2015
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  • 16 Citations
Abstract PDFPubReader   ePub   
Abstract Objective

The imbalance between pro-inflammatory and anti-inflammatory cytokines may underlie different pain states. Although ascorbic acid is the most important physiological antioxidant that affects host defense mechanisms and immune homeostasis, there is limited information on the effects of ascorbic acid on the production of cytokines.


In this study, we investigated the in vitro effect of L-ascorbic acid (AA) on the production of pro-inflammatory and anti-inflammatory cytokines by stimulating C57BL/6 mouse splenocytes with the polyclonal activators lipopolysaccharide or concanavalin A.


AA significantly downregulated the expression of IL-6, IL-12, and TNF-α at 48 h and 72 h in mouse splenocytes treated with a combination of polyclonal activators and AA. AA treatment also resulted in upregulation of IL-4 and IL-10 at 72 h. These findings demonstrated that AA significantly potentiated production of anti-inflammatory cytokines whereas there was an inverse association between AA and expression of pro-inflammatory cytokines in mouse splenocytes.


AA may have potential applications in the reduction of inflammatory pain because of its function in modulating the production of cytokines. However, further in vivo investigations are necessary to elucidate the mechanisms involved.


Citations to this article as recorded by  
  • Antioxidant Activity, Stability in Aqueous Medium and Molecular Docking/Dynamics Study of 6-Amino- and N-Methyl-6-amino-L-ascorbic Acid
    Lara Saftić Martinović, Nada Birkic, Vedran Miletić, Roberto Antolović, Danijela Štanfel, Karlo Wittine
    International Journal of Molecular Sciences.2023; 24(2): 1410.     CrossRef
  • Anticancer Activity of Mineral-Supplemented Organically Cultivated Carrot on HT-29 Cells and Its Anti-Inflammatory Effect on Mice Splenocytes
    Yanni Pan, Yeon-Jun Lee, Sin-Il Sin, Seung-Hwan Park, Kun-Young Park
    Applied Sciences.2023; 13(16): 9209.     CrossRef
  • Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency
    Chanunya Santiworakul, Wilasinee Saisorn, Nuanpan Siripen, Asada Leelahavanichkul, Pornpimol Rianthavorn
    Pediatric Nephrology.2023;[Epub]     CrossRef
  • Sitagliptin Attenuates the Cognitive Deficits in L-Methionine-Induced Vascular Dementia in Rats
    Suzan A. Khodir, Manar A. Faried, Huda I. Abd-Elhafiz, Eman M. Sweed, Krzysztof Siemianowicz
    BioMed Research International.2022; 2022: 1.     CrossRef
  • Combination Treatment of Omega-3 Fatty Acids and Vitamin C Exhibited Promising Therapeutic Effect against Oxidative Impairment of the Liver in Methotrexate-Intoxicated Mice
    Mohammed Alorabi, Doha Saad Mohammed, Gomaa Mostafa-Hedeab, Suzy A. El-Sherbeni, Walaa A. Negm, Ali Ismail A. Mohammed, Hayder M. Al-kuraishy, Nani Nasreldin, Saqer S. Alotaibi, Bashir Lawal, Gaber El-Saber Batiha, Carlos Adam Conte-Junior, Valeria Pasciu
    BioMed Research International.2022; 2022: 1.     CrossRef
  • STAT3 inhibition decreases ATP-induced MUC8 gene expression in human airway epithelial cells
    Cheol Hong Kim, Kyoung Seob Song
    Kosin Medical Journal.2022; 37(2): 134.     CrossRef
  • Critical review on the immunomodulatory activities of carrot’s β-carotene and other bioactive compounds
    Gemala Anjani, Fitriyono Ayustaningwarno, Rafika Eviana
    Journal of Functional Foods.2022; 99: 105303.     CrossRef
  • Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
    Agnieszka Gęgotek, Elżbieta Skrzydlewska
    Antioxidants.2022; 11(10): 1993.     CrossRef
  • The Effect of Ascorbic Acid on Interleukin-10 and Tumor Necrosis Factor-α Cytokines in Rattus norvegicus with Endometritis
    Muhammad Oky Prabudi, M. F. G. Siregar, I. P. A. Nasution, S. Ilyas
    Open Access Macedonian Journal of Medical Sciences.2021; 9(A): 798.     CrossRef
  • Effect of Ascorbic Acid on Differentiation, Secretome and Stemness of Stem Cells from Human Exfoliated Deciduous Tooth (SHEDs)
    Shilpa Bhandi, Ahmed Alkahtani, Mohammed Mashyakhy, Abdulaziz S. Abumelha, Nassreen Hassan Mohammad Albar, Apathsakayan Renugalakshmi, Mazen F. Alkahtany, Ali Robaian, Asma Saleh Almeslet, Vikrant R. Patil, Saranya Varadarajan, Thodur Madapusi Balaji, Rod
    Journal of Personalized Medicine.2021; 11(7): 589.     CrossRef
  • Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research
    Hui Yee Tan, Sik Loo Tan, Seow Hui Teo, Margaret M. Roebuck, Simon P. Frostick, Tunku Kamarul
    PeerJ.2020; 8: e8740.     CrossRef
  • Active Cousinia thomsonii Extracts Modulate Expression of Crucial Proinflammatory Mediators/Cytokines and NFκB Cascade in Lipopolysaccharide-Induced Albino Wistar Rat Model

    Khalid Bashir Dar, Ishfaq Shafi Khan, Shajrul Amin, Aijaz Hassan Ganie, Aashiq Hussain Bhat, Showkat Ahmad Dar, Bilal Ahmad Reshi, Showkat Ahmad Ganie
    Journal of Inflammation Research.2020; Volume 13: 829.     CrossRef
  • The potential cytoprotective effect of Vitamin C and Vitamin E on monosodium glutamate-induced testicular toxicity in rats
    Safaa Mohamed El Kotb, Dalia El-sayed El-ghazouly, Omnia Ameen
    Alexandria Journal of Medicine.2020; 56(1): 134.     CrossRef
  • Combination of ascorbic acid and calcitriol attenuates chronic asthma disease by reductions in oxidative stress and inflammation
    Farzaneh Kianian, Seyed Morteza Karimian, Mehri Kadkhodaee, Nasrin Takzaree, Behjat Seifi, Soheila Adeli, Elham Harati, Hamid Reza Sadeghipour
    Respiratory Physiology & Neurobiology.2019; 270: 103265.     CrossRef
  • Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens
    Daniel Hernandez-Patlan, Bruno Solis-Cruz, Karine P. Pontin, Juan D. Latorre, Xochitl Hernandez-Velasco, Ruben Merino-Guzman, Abraham Mendez-Albores, Billy M. Hargis, Raquel Lopez-Arellano, Guillermo Tellez-Isaias
    Pathogens.2019; 8(4): 229.     CrossRef
  • Amelioration of Escherichia coli‐induced endometritis with ascorbic acid in non‐pregnant mouse models
    Enitome Evi Bafor, Ikechukwu Onwukpa, Anne Oghenekevwe Itemire, Osemelomen Omoruyi, Ejiroghene Eferoba‐Idio, Kevin Odega, Osas Jim Eghianruwa
    American Journal of Reproductive Immunology.2018;[Epub]     CrossRef
A Case of Retrospective Four-dimensional Computed Tomography for Gated Radiotherapy
Sang Wook Lim, Sun Young Ma, Tae Sig Jeung
Kosin Med J. 2009;24(1):135-137.   Published online June 30, 2009
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Selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4B epithelial ovarian cancer: a case series
Eun Taeg Kim, Seung Yeon Oh, Sun Young Ma, Tae Hwa Lee, Won Gyu Kim
Received October 12, 2023  Accepted October 28, 2023  Published online November 21, 2023  
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Abstract PubReader   ePub   
Although the efficacy of surgery followed by taxane- and platinum-based systemic chemotherapy has been clearly demonstrated in the standard first-line treatment of epithelial ovarian cancer, the role of radiation therapy for distant lymph node metastasis in patients with epithelial ovarian cancer is not well-established due to a lack of reported studies. We identified four patients who underwent selective adjuvant radiation therapy for neck and para-aortic lymph node lesions after primary debulking surgery between 2020 and 2022, followed by platinum-based chemotherapy for stage 4B high-grade serous ovarian cancer. Through a retrospective review of medical records, we analyzed patient clinicopathologic features, treatment course, and imaging findings. The median age was 49.25 years (range, 46–54 years). All patients had the International Federation of Gynecology and Obstetrics stage 4B disease. Following primary debulking surgery, all patients received weekly paclitaxel-carboplatin chemotherapy and maintenance treatment with poly(ADP-ribose) polymerase (PARP) inhibitors. All patients received selective adjuvant radiation therapy for neck and para-aortic lymph node metastasis before PARP inhibitor maintenance. The median follow-up time was 36.75 months (range, 19–45 months). All patients achieved a complete response. None of the patients experienced disease recurrence or died during the follow-up period. The management of distant lymph node metastasis in patients with epithelial ovarian cancer remains a matter of debate. Selective adjuvant radiation therapy in first-line treatment for ovarian cancer appears to be a feasible approach with maintenance therapy for stage 4B epithelial ovarian cancer.

KMJ : Kosin Medical Journal