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Sol Jin 2 Articles
Adverse events following vaccination against coronavirus disease 2019
Minji Jeon, Sol Jin, Jin-Young Lee
Kosin Med J. 2022;37(1):18-26.   Published online March 28, 2022
DOI: https://doi.org/10.7180/kmj.22.017
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
To overcome the coronavirus disease 2019 (COVID-19) pandemic, large-scale vaccination is proceeding worldwide. As of December 23, 2021, 10 novel vaccines against COVID-19 had been validated for use by the World Health Organization (WHO), including BNT162b2 (Pfizer/BioNTech), mRNA-1273 (Moderna), AZD1222 (AstraZeneca), and Ad26.COV2.S (Janssen). These novel vaccines against COVID-19 showed acceptable safety profiles in randomized clinical trials. Most adverse events following immunization (AEFIs) associated with these novel vaccines ranged from mild to moderate and improved within a few days after administration. However, serious adverse events associated with vaccines that were not observed in the clinical trials were reported in real-world data. Adverse events of special interest include not only anaphylaxis or neurologic disorders (such as Guillain-Barré syndrome, transverse myelitis, or seizure) but also myocarditis or pericarditis associated with the messenger RNA (mRNA) vaccines and thrombosis with thrombocytopenia syndrome associated with the adenovirus-vector vaccines. Although several fatal cases of serious AEFIs that may have been related to vaccination have been reported, it is recommended to continue vaccination because the benefits of vaccines’ preventive effects against COVID-19 outweigh the risks of rare serious adverse events. Long-term monitoring of various AEFIs and sharing of clinical experiences are necessary for safe and efficient large-scale vaccination.
Effects of White-coat Hypertension on Heart Rate Recovery and Blood Pressure Response during Exercise Test
Sol Jin, Jung Ho Heo, Bong Jun Kim
Kosin Med J. 2020;35(2):89-100.   Published online December 31, 2020
DOI: https://doi.org/10.7180/kmj.2020.35.2.89
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  • 1 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

White-coat hypertension is defined as high blood pressure (BP) on clinical assessment but normal BP elsewhere or on ambulatory measurement. Autonomic dysfunction may be one of the mechanisms causing white-coat hypertension. Slowed heart rate recovery and excessive BP response during exercise test are associated with autonomic dysfunction. The purpose of this study was to determine the association between white-coat hypertension and abnormal autonomic nervous system response.

Methods

We assessed 295 patients stratified into three groups via 24hr ambulatory BP monitoring, following 2017 ACC/AHA guidelines: normal BP group, white-coat hypertension group, and a hypertension group. We analyzed medical history, blood test, echocardiography, 24hr ambulatory BP monitoring, and exercise test data.

Results

There was no difference in basement characteristics and echocardiography among the groups. Blunted heart rate recovery of each group showed a significant difference. Control group had 0% blunted heart rate recovery, but 33.3% in white coat group and 27.6% in true hypertension group (P < 0.001). Also, in the control group, 4.5% showed excessive BP response, but 31.5% in the white coat hypertension group and 29.3% in the true hypertension group (P < 0.001). Excessive BP response during the exercise test or blunted heart rate recovery, which is an indicator of autonomic nervous system abnormality, was more common in the hypertensive group and white-coat hypertension group than in the normal BP group.

Conclusions

These results confirmed that white-coat hypertension has an autonomic nervous system risk. Therefore, white-coat hypertension can be a future cardiovascular risk factor.

Citations

Citations to this article as recorded by  
  • Study on Maximal Oxygen Uptake of Respiration and Heart Rate in Exercise Training Based on Regression Equation
    Yongqing Liang, Qiufen Yu, Balakrishnan Nagaraj
    Journal of Healthcare Engineering.2022; 2022: 1.     CrossRef

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