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Seong Hoon Shin 14 Articles
Retrospective analysis on the clinical efficacy of bevacizumab combined with FOLFOX4 in the first line treatment of metastatic colorectal cancer
Eun Mi Lee, Lee Chun Park, Ho Sup Lee, Seong Hoon Shin, Yang Soo Kim
Kosin Med J. 2017;32(2):170-178.   Published online January 19, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.2.170
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

The addition of bevacizumab to standard chemotherapy has been improved survival outcomes in patients with metastatic colorectal cancer. However, the combination of bevacizumab with oxaliplatin-based chemotherapy as first-line treatment showed limited survival benefit. The purpose of this study was to investigate the clinical efficacy and toxicity of the combination of bevacizumab to oxaliplatin and leucovorin (FOLFOX4) in the first-line treatment of patient with metastatic colorectal cancer.

Methods

Between December 2004 and September 2009, medical records of patients who were diagnosed with metastatic colorectal cancer and received the first line chemotherapy with bevacizumab and FOLFOX4, were retrospectively reviewed.

Results

A total of forty patients were analyzed. The median age of the patients was 55 years (range, 33-80), and 55% was male. The patients received a total of 206 cycles of therapy (median 4 cycles per patient; range 1 – 15 cycles). Of these 40 patients, none achieved complete response (CR) and 15 achieved a partial response (PR), for the overall response rate (ORR) 37.5% (95% CI, 22.5-52.5). Median progression free survival (PFS) was 6.9 months (95% CI, 3.4-10.5) and median overall survival (OS) was 22.6 months (95% CI, 17.3-27.8The most common grade 3 or 4 hematologic toxicity and non-hematologic toxicity were neutropenia (10.0%) and diarrhea (10.0%), respectively. Two patients experienced gastrointestinal perforation.

Conclusions

In this study, the combination bevacizumab with FOLFOX4 was associated with favorable OS, but did not showed favorable PFS and ORR.

Prognostic Significance of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Diffuse Large B-Cell Lymphoma Patients Treated with R-CHOP
Lee Chun Park, Ho Sup Lee, Eun Mi Lee, Seong Hoon Shin, Yang Soo Kim
Kosin Med J. 2016;31(2):122-133.   Published online January 20, 2016
DOI: https://doi.org/10.7180/kmj.2016.31.2.122
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Abstract Objectives

The both values of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) were reported as indexes of systemic inflammation and readily available and inexpensive prognostic markers in patients with solid cancer. The objective of this study was to clarify whether the NLR and PLR were significant prognostic markers in Korean diffuse large B-cell lymphoma (DLBCL) patients treated with R-CHOP as a first line therapy.

Methods

: We retrospectively collected the clinical data of ninety nine DLBCL patients treated with R-CHOP from 2004 to 2012 and analyzed. NLR and PLR were calculated from complete blood count (CBC) and differential leukocyte count.

Results

: In univariate analysis, NLR was significantly associated with 5-year progression free survival(PFS) rate (P= 0.039), but not significantly associated with 5-year overal survival (OS) rate (P= 0.276). PLR was not significantly associated with 5-year PFS (P= 0.632) and OS rate (P= 0.855). In multivariate analysis, NLR was not a significant independent prognostic factor for 5-year PFS (P= 0.415) and OS rate (P= 0.991).

Conclusion

: The NLR can be considered a useful predictor of survival outcome. The PLR is not a valid predictor of survival outcome.

Citations

Citations to this article as recorded by  
  • Prognostic role of neutrophil-to-lymphocyte ratio in diffuse large B cell lymphoma patients: an updated dose–response meta-analysis
    Shidai Mu, Lisha Ai, Fengjuan Fan, You Qin, Chunyan Sun, Yu Hu
    Cancer Cell International.2018;[Epub]     CrossRef
2 Cases of Pubic Insufficiency Fractures Mimicking Malignanant Tumor
Jong Hwa Park, Kyung Woo Lee, Dong Hyun Kim, Soon Il Lee, Byung Kil Ha, Seong Hoon Shin
Kosin Med J. 2011;26(2):173-177.   Published online December 1, 2011
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Herpesviridae Viral Infections Following Stem Cell Transplantation in Hematologic Malignancy
Ho Sup Lee, Hee Sang Tag, Seong Hoon Shin, Yang Soo Kim, Sung Jin Nam, Hye Soo Kim, Jin Hee Park, Su Hyeon Jeong, Sung Bin Kim, Ye Na Kim
Kosin Med J. 2010;25(1):20-26.   Published online June 30, 2010
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A Case of HIV Related Gastric Non-Hodgkin's Lymphoma Treating with R-CHOP
Seong Hoon Shin
Kosin Med J. 2008;23(4):197-201.   Published online December 31, 2008
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Expression of MAGE in Pleural Fluid for the Differential Diagnosis of Benign and Malignant Pleural Effusion
Chul Ho Oak, Tae Won Jang, Seong Hoon Shin, Man Hong Jung
Kosin Med J. 2008;23(3):17-21.   Published online September 30, 2008
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A Case of Pyothorax-Associated Pleural T Cell Lymphoma
Seong Hoon Shin
Kosin Med J. 2008;23(3):79-81.   Published online September 30, 2008
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Case Report : Leptomeningeal Granulocytic Sarcoma of Chronic Myelogenous Lleukemia
Seong Hoon Shin
Kosin Med J. 2008;23(3):82-85.   Published online September 30, 2008
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A Case of Clopidogel Induced Thrombotic Thrombocytopenic Purpura
Seong Hoon Shin
Kosin Med J. 2008;23(3):86-89.   Published online September 30, 2008
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4 Cases of Extramedullary Plasmacytomas Treated with Bortezomib and Dexamethasone
Jong Hyun Paek, Eun Young Lee, Ri Ra Jang, Chang Bae Sohn, Eun Kyung Shin, Jeong Ah Seo, Jee Suk Lee, Ho Seop Lee, Sang Min Lee, Seong Hoon Shin, Yang Soo Kim
Kosin Med J. 2007;22(2):216-220.   Published online December 31, 2007
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Prognostic Value of Serum B2-microglobulin in Diffuse Large B-cell Lymphomas
Wan Kyu Eo, Seong Hoon Shin
Kosin Med J. 2006;21(1):61-68.
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A Case of Rhabdomyolysis associated with Cerivastatin and Cyclosporine Combination Therapy in a Kidney Transplant Recipient
Seong Hoon Shin, Min Dae Kim, Seung Su Kang, Chan Ook Kim, Jee Young Lee, Jae Sup Eum, Kil Su Kim, Sung Il Kweon, Yeon Soon Jung, Hark Rim
Kosin Med J. 2002;17(1):137-141.
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Prevalence of Multidrug Resistant Tuberculosis
Kil Su Kim, Seong Hoon Shin, Min Dae Kim, Ik Soo Jeon, Seung Su Kang, Sung Il Kwon, Chul Ho Oak, Hyun Myung Cho, Tae Won Jang, Maan Hong Jung
Kosin Med J. 2001;16(1):92-96.
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Esophageal Motility Abnormalities in Non-Insulin Dependent Diabetic Patients
Jee Young Lee, Sang Won Yi, Seong Hoon Shin, Jee Youn Kim, Moo In Park, Seon Ja Park, Ja Young Koo
Kosin Med J. 2001;16(1):76-84.
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KMJ : Kosin Medical Journal