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Seok-O Park 1 Article
Case of hyperosmolar hyperglycemic state by a sodium-glucose cotransporter 2 inhibitor
In-Young Nho, Hae-Sung Kim, Nam-Kyu Kang, Myung-Won Lee, Soo-Kyung Kim, Seok-O Park
Kosin Med J. 2018;33(3):402-408.   Published online December 31, 2018
DOI: https://doi.org/10.7180/kmj.2018.33.3.402
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Abstract PDFPubReader   CrossRef-TDMCrossref - TDM

Inhibitors of sodium-glucose cotransporters type 2 (SGLT2) are proposed as a novel approach for the management of type 2 diabetes mellitus. SGLT2 cotransporters are responsible for reabsorption of 90 % of the glucose filtered by the kidney. The glucuretic effect resulting from SGLT2 inhibition contributes to reduce hyperglycaemia and also assists weight loss and blood pressure reduction.

In this study, we presented the case of a 59-year-old male who developed hyperosmolar hyperglycemic state (HHS), possibly caused by a sodium-glucose cotransporter 2 (SGLT2) inhibitor, a novel class of antihyperglycemic agents. This case highlights that HHS can develop in patients with diabetes treated with SGLT2 inhibitors


KMJ : Kosin Medical Journal