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Sang Uk Lee 9 Articles
The Combination Therapy with Peg-interferon Alfa and Ribavirin for Chronic Hepatitis C in Korea as an Initial Treatment
Dong Hyun Park, Sang Uk Lee, Jin Seok Yu, Jun Seop Lee, Hye Jung Kwon
Kosin Med J. 2012;27(2):111-118.   Published online December 27, 2012
DOI: https://doi.org/10.7180/kmj.2012.27.2.111
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

The combination therapy with peginterferon and ribavirin has been used to treat chronic hepatitis C for several years in Korea but there is a few report about the results of the treatment. We evaluated safety and efficacy of the combination therapy with Peg-interferon and ribavirin and analyzed factors that may affect treatment.

Methods

Total 72 untreated chronic hepatitis C patients were administered pegylated interferon alfa-2a (180µg/week) or alfa-2b (1.5µg/kg/week) and ribavirin (800 mg/day in genotype 2, 1000-1200 mg/day in genotype 1). Duration of the treatment was 24 weeks in genotype 2 and 48 weeks in genotype 1. Response of the treatment was evaluated by rapid virologic response (RVR), early virologic response (EVR), end treatment virologic response (ETR), sustained virologic response (SVR) and adverse event.

Results

The RVR, EVR, ETR, SVR were 61.8%, 82.5%, 88.9% and 80.5% retrospectively. The SVR of genotype 1 was 63.4% and non-genotype 1 was 96.7%. Genotype (Odds ratio: 14.92) was an independent predictor of the SVR. Leukocytopenia, flu-like symptoms, itching, rash and anemia were common adverse events of the combination therapy and if then we reduced dose and there was one case of cessation.

Conclusions

The combination therapy with Peg-interferon and ribavirin shows efficacy to the Korean patients with chronic hepatitis C as an initial treatment. Genotypes 2 and 3 were more likely to have a sustained virologic response.

The Efficacy of Adefovir Dipivoxil in Chronic Hepatitis B with Lamivudine Resistance
Jee Suk Lee, Lee La Jang, Sang Uk Lee, Byung Hoon Han, Byung Chul Yoon
Kosin Med J. 2008;23(2):36-43.   Published online June 30, 2008
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The correlation between cyclooxygenase-2 and p53 expression in hepatocellular carcinoma and the effects recurrence after surgery
Byung CHeol Yun, Byung Hoon Han, Sang Uk Lee, Bang Hur
Kosin Med J. 2007;22(1):72-80.   Published online June 30, 2007
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Expression profile of topoisomerase, ras and myc genes in HL-60 cells treated with camptothecin
In Cheol Jeong, Neung Ju Lee, Sang Uk Lee, Song Jae Lee, Moo Youn Cho
Kosin Med J. 2004;19(1):271-278.
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A Case of Esophageal Perforation Accompanied with Pneumothorax Developed during Endoscopic Retrograde Cholangiogram
Sung In Ha, Sin Kim, Yuri Kim, Chan Bog Park, Jee Hyun Lee, Byung Cheol Yun, Byung Hoon Han, Sang Uk Lee, Dong Hoon Shin
Kosin Med J. 2004;19(1):101-105.
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Study of HBV and HCV coinfection according to serologic marker in patients with chronic liver disease
Byung Cheol Yun, Byung Hoon Han, Sang Uk Lee
Kosin Med J. 2004;19(1):94-100.
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Natural Killer cell activity and T cell subsets in peripheral blood of hepatocellular carcinoma according to etiology
Jin Wuk Hur, Paul Choi, Hyun Jeung Lim, Su Hong Kim, Eun Seok Kim, Byung Chul Yun, Byung Hun Han, Sang Uk Lee
Kosin Med J. 2003;18(1):36-42.
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The Study for Clinical Significance of CD34 Expression in Hepatocellular Carcinoma
Ki Bum Kwon, Byung Joo Choe, Jun Chul Pyun, Byung Chul Youn, Sang Uk Lee, Byung Hoon Han
Kosin Med J. 2001;16(1):1-6.
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Effects of benzo(a)pyrene on the DNA topoisomerase Ⅱ-mediated DNA cleavage in human c-myc protooncogene
In Cheol Jeong, Song Jae Lee, Moo Youn Cho, Sang Uk Lee
The Journal of Kosin Medical College. 1995;10(2):91-95.
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KMJ : Kosin Medical Journal