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Namho Kim 1 Article
The clinical features and infectious etiologies of acute diarrhea in immunocompromised hosts
Jin Young Lee, Ye Na Kim, Namho Kim, Kyoung Soon Cho, Ji Young Park
Kosin Med J. 2017;32(2):191-203.   Published online December 29, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.2.191
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  • 3 Citations
Abstract PDFPubReader   ePub   
Objectives

The acute diarrhea is a common complaint among immunocompromised hosts, and may cause life threatening event. The infectious etiologies vary depending on virus, bacteria, and parasites. The most common etiology of acute gastroenteritis is known as enteric virus in Korea.1 But there are few studies about the infectious etiology of acute gastroenteritis in immunocompromised hosts.23 The aim of this study was to investigate the infectious etiologies of acute diarrhea in immunocompromised hosts.

Methods

Seventy three patients were enrolled prospectively in a university hospital from January 2013 to July 2014. Immunocompromised hosts included above 65-year-old people, patients with chronic diseases, solid organ or stem cell transplants, solid organ malignancies, hematologic malignancies, immunosuppressive or steroid taking patients. The clinical data were collected and stool samples collected during diarrhea were undergone laboratory analysis for enteric viruses and bacterial enteropathogens including Salmonella spp., Shigella spp., and Clostridium difficile.

Results

Fifty five patients were analyzed as follows : above 65 year-old people were 36 cases (66%), previous antibiotic usage was 22 cases (41.5%). 44 cases (81.1%) were admitted to general ward whereas 9 cases to ICU (17%). 41 cases (73.6%) were treated with antibiotics. Positive C. difficile toxin assays were 6 cases (11.9%). Other infectious etiologies were not found.

Conclusions

C. difficile infection was more common infectious etiology while enteric viruses and other bacteria are not associated with acute diarrhea among immunocompromised hosts in this study. So C. difficile infection must be considered preferentially in immunocompromised hosts with acute diarrhea.

Citations

Citations to this article as recorded by  
  • Evaluation of the detection of diarrhoea-associated RNA viruses in immunocompromised children in Iran
    Shokouh Yasaie, Seyed Dawood Mousavi Nasab, Saeed Shams, Atousa Ferdousi, Hooman Kaghazian
    Infection Prevention in Practice.2024; 6(3): 100370.     CrossRef
  • Prevalence of Human Adenovirus, Epstein-Barr Virus, and Cytomegalovirus in Pediatric Hematologic Diseases in Iran
    Shokouh Yasaie, Atousa Ferdousi, Seyed Dawood Mousavi Nasab, Hooman Kaghazian, Saeed Shams
    Infection Epidemiology and Microbiology.2024; 10(1): 51.     CrossRef
  • Mucoprotectants
    Sung Eun Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2022; 22(2): 108.     CrossRef

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