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Min Jeong Kim 22 Articles
Nilotinib-Induced Acute Interstitial Nephritis during the Treatment of Chronic Myeloid Leukemia
Min Jeong Kim
Kosin Med J. 2021;36(2):153-160.   Published online December 31, 2021
DOI: https://doi.org/10.7180/kmj.2021.36.2.153
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM

Tyrosine kinase inhibitors (TKIs) are targeted therapy drugs that selectively inhibit protein kinases. Nephrotoxicity associated with TKIs is uncommon. We report a case of a 39-year-old man with acute kidney injury that developed after nilotinib treatment for chronic myeloid leukemia (CML). The renal function of the patient decreased during treatment with nilotinib but improved when treatment was discontinued due to neutropenia. However, the renal function of the patient deteriorated again with the reintroduction of nilotinib for treatment. A renal biopsy revealed acute interstitial nephritis (AIN). The patient had no history of comorbidities and medication causing renal injury. Finally, we diagnosed the patient with nilotinib-induced AIN. After switching to imatinib mesylate, the renal function of the patient stabilized without further deterioration. Our case indicates that nilotinib can be a potential cause of renal dysfunction by inducing AIN when renal function deteriorates in patients treated with nilotinib.

Effect of Rheumatoid Factor on Vascular Stiffness in General Population without Joint Symptoms
Ji Hyun Lee, Hee Sang Tag, Geun Tae Kim, Min Jeong Kim, Seung Geun Lee, Eun Kyung Park, Dong Wa Koo
Kosin Med J. 2017;32(1):25-35.   Published online January 19, 2017
DOI: https://doi.org/10.7180/kmj.2017.32.1.25
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  • 2 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Objectives

The role of rheumatoid factor (RF) in vascular stiffness and cardiovascular risk in subjects without joint symptoms remains unclear. We investigated vascular stiffness in subjects without joint symptoms using pulse wave velocity (PWV), calculated Framingham risk scores (FRS), an estimator of cardiovascular risk, and analyzed whether vascular stiffness and FRS were affected by RF.

Methods

Two hundred forty-two subjects were included in this population-based study. RF was quantified with turbid immunometry using a cut-off of RF > 15 IU/ml to denote RF positivity. Information was then obtained on joint symptoms. Brachial-ankle PWV (baPWV) was measured using an automated device.

Results

Of the 242 subjects, 15 were RF-positive. RF-positive subjects without joint symptoms had a higher baPWV and FRS than RF-negative subjects without joint symptoms, but the difference did not reach statistical significance. However, when we stratified the subjects into two groups (group A – high RF: RF ≥ 40 IU/ml; group B – low RF: RF < 40 IU/ml), group A showed significantly higher baPWV (1640.7 ± 179.6 ㎝/s vs. 1405.7 ± 225.7 ㎝/s, P= 0.008) and FRS (25.7 ± 4.87 vs. 11.8 ± 9.6, P< 0.001). Multiple regression analysis was used to examine potential confounders, and RF exhibited significant but modest effects on baPWV (adjusted R-squared = 0.038, P= 0.030).

Conclusions

In a sample of the general population without joint symptoms, higher levels of RF were associated with increased vascular stiffness, suggesting a pathophysiologic link between RF and endothelial dysfunction.

Citations

Citations to this article as recorded by  
  • Model-Based Design of Defense Cyber-Physical Systems to Analyze Mission Effectiveness and Network Performance
    Bong Gu Kang, Kyung-Min Seo, Tag Gon Kim
    IEEE Access.2019; 7: 42063.     CrossRef
  • Communication Analysis of Network-Centric Warfare via Transformation of System of Systems Model into Integrated System Model Using Neural Network
    Bong Gu Kang, Kyung-Min Seo, Tag Gon Kim
    Complexity.2018; 2018: 1.     CrossRef
Polycystic Ovary Syndrome
Yong-Il Ji, Min Jeong Kim
Kosin Med J. 2015;30(2):109-114.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.2.109
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Abstract

Polycystic ovary syndrome affects 6%-7% of reproductive-aged women, making it the most common endocrine disorder in this population. It is characterized by chronic anovulation and hyperandrogenism. Affected women may present with reproductive manifestations such as irregular menses or infertility, or cutaneous manifestations, including hirsutism, acne, or male-pattern hair loss. Over the past decade, several serious metabolic complications also have been associated with polycystic ovary syndrome including type 2 diabetes mellitus, metabolic syndrome, sleep apnea, and possibly cardiovascular disease and nonalcoholic fatty liver disease. In addition to treating symptoms by regulating menstrual cycles and improving hyperandrogenism, it is imperative that clinicians recognize and treat metabolic complications. Lifestyle therapies are first-line treatment in women with polycystic ovary syndrome, particularly if they are overweight. Pharmacological therapies are also available and should be tailored on an individual basis. This article reviews the diagnosis, clinical manifestations, metabolic complications, and treatment of the syndrome.

Students' Satisfaction and Perception of Problem Based Learning Evaluated by Questionnaire
Min Jeong Kim
Kosin Med J. 2015;30(2):149-157.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.2.149
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  • 1 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Abstract Objectives

The aim of this study is to analyze the student's satisfaction and perception in problem based learning of Kosin University College of Medicine, and to propose effective strategies for improvement of problem based learning.

Methods

Students satisfaction of problem based learning was assessed using the structured questionnaire. The questionnaire consisted of 33 items covered satisfaction of self-evaluation and small group activity, learning resources and environment, tutor and content and construction of modules.

Result

A total of 80 students were surveyed. Students recognized PBL as more effective and interesting learning method than traditional lectures. Most of students highly satisfied with self-directed learning of their own and small group, tutor, composition and contents of modules. Students had difficult process to build a logical clinical reasoning by combining clues in the PBL process. Students regard that they can easily connect knowledge in real-clinical situations with the greatest advantages of PBL. Students cited as the biggest disadvantage is that students may not receive a fair evaluation.

Conclusion

Through the results of this survey it showed that students are satisfied with the PBL classes and recognized as effective compared to traditional instructor-led classes. However, further efforts in improving evaluation system and learning environments was necessary for the success of the PBL curriculum.

Citations

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  • Problem based learning approach increases the academic satisfaction of health science students in Ethiopian universities: a comparative cross sectional study
    Selamawit Girma Tadesse, Dereje Girma Tadesse, Eyaya Habtie Dagnaw
    BMC Medical Education.2022;[Epub]     CrossRef
Meningoencephalitis associated with Parvovirus B19 Infection in an Immunocompetent Patient
Dae-Seung Lee, Jin-Hyung Lee, So-Young Huh, Min Jeong Kim, Meyung-Kug Kim, Bong-Goo Yoo
Kosin Med J. 2015;30(2):181-185.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.2.181
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  • 1 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Abstract

Parvovirus B19 (PVB19) infection is a rare cause of meningoencephalitis. A 53-year-old previously healthy woman presented with fever, headache, and multiple erythema on the both legs. Cerebrospinal fluid study revealed pleocytosis and elevated opening pressure and protein level. Brain MRI showed multiple, asymmetric, hyperintensity in the brain stem, basal ganglia, white matter, and gray matter. Anti-B19 IgM antibody and PCR for PVB19 were positive in serum. Clinician should consider PVB19 infection in any case of acute febrile illness with erythema and meningoencephalitis

Citations

Citations to this article as recorded by  
  • Clinical manifestations and treatment outcomes of parvovirus B19 encephalitis in immunocompetent adults
    Jin-Sun Jun, Jangsup Moon, Jung-Ick Byun, Jun-Sang Sunwoo, Jung-Ah Lim, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Manho Kim, Sang Kun Lee, Kon Chu
    Journal of NeuroVirology.2017; 23(6): 903.     CrossRef
Increased carotid atherosclerosis and carotid artery stiffness according to the disease duration and activity in patients with systemic lupus erythematosus
Gi Sup Byun, Ji Hyun Lee, Kyoung Im Cho, HongJik Lee, Hyun Jung Yeo, Min Jeong Kim, Ho Joon Im
Kosin Med J. 2014;29(2):107-116.   Published online December 18, 2014
DOI: https://doi.org/10.7180/kmj.2014.29.2.107
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Abstract PDFPubReader   CrossRef-TDMCrossref - TDM
Abstract Objective:

The ᅵink among carotid intimamedia thickness (IMT), vascular elastic property and the disease activity of systemic lupus erythematosus (SLE) is not well defined. We investigated the association between carotid atherosclerosis, elastic properties of the carotid arterial wall and clinical parameters of SLE.

Methods:

Fifty-one SLE patients and fifty healthy controls were included. Peak systolic global circumferential and posterior radial strains of carotid artery were measured to assess the elastic properties. Beta stiffness index was used as conventional method for the distensibility of the carotid artery. Information concerning SLE duration, cumulative dose of steroids and/or immunosuppressive drug intake was recorded, and SLE activity was assessed by SLE disease activity index (SLEDAI) score.

Results:

Carotid plaques were more common in SLE patients. SLE patients with plaques were 㢌der and showed the increased mean ᅵMT, high sensitivity C-reactive protein (hs CRP), IgG anti-cardi㢌ipin antibody (aCL), and longer disease duration compared with those without plaques. Peaksyst㢌ic global circumferential and posterior radial strain as well β stiffness index were significantly lower in SLE group. Age, disease duration, hsCRP, IgG aCL showed significant correlations with mean ᅵMT and parameters of carotid elastic property (all P's<0.05).

Conclusions:

Carotid atherosclerosis was more common in SLE patients, and carotid arterial stiffness had significant correlation with disease duration, hsCRP and IgG aCL level. Speckle tracking strain imaging is a comparative method for the assessment of elastic properties of carotid artery of SLE patients.

A Case of Hiccups Associated with Dopaminergic Medication
Yoon Seok ha, Min Jeong Kim
Kosin Med J. 2010;25(2):197-199.   Published online December 31, 2010
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Lateral Medullary Infarction Presenting as Isolated Vertigo and Ataxic Gait
Ju Young Na, Ji Hyun Lee, Min Jeong Kim, Meyung Kug Kim, Bong Goo Yoo
Kosin Med J. 2010;25(2):200-202.   Published online December 31, 2010
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Central Pontine Myelinolysis Presenting as Pathological Crying
Kwang Soo Kim, Min Jeong Kim
Kosin Med J. 2010;25(1):27-30.   Published online June 30, 2010
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Tsutsugamushi Disease with Meningitis: Clinical Features and Cerebrospinal Fluid Findings
Kwang Soo Kim, Min Jeong Kim
Kosin Med J. 2009;24(2):125-129.   Published online December 31, 2009
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Tolosa-Hunt Syndrome Associated with Facial Nerve Palsy
Sung Jin Kang, Kwang Soo Kim, Ji Hyun Lee, Jong Kuk Kim, Min Jeong Kim
Kosin Med J. 2009;24(1):180-183.   Published online June 30, 2009
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Post Micturitional Headache Associated with Bladder Pheochromocytoma
Yun Suk Ha, Sung Jin Kang, So Young Huh, Ji Hyun Lee, Min Jeong Kim, Jong Kuk Kim, Kwang Soo Kim
Kosin Med J. 2009;24(1):184-186.   Published online June 30, 2009
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Transient Global Amnesia in a Patient with Migraine Without Aura
Sang Jin Kang, Kwang Soo Kim, Ji Hyun Lee, Jong Kuk Kim, Min Jeong Kim
Kosin Med J. 2008;23(4):268-270.   Published online December 31, 2008
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A Case of Dystonia – Parkinsonism Syndrome
So Young Heo, Min Jeong Kim
Kosin Med J. 2008;23(2):100-102.   Published online June 30, 2008
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A Case of Idiopathic Hypoparathyroidism Associated with Striatopallidodentate Calcinosis and Intention Tremor
Sung Jin Kang, Min Jeong Kim, Hark Rim
Kosin Med J. 2008;23(2):103-105.   Published online June 30, 2008
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Relation between Poststroke Depression with Serum levels of Homocysteine, Vitamin B 12 and Folate
Ji Su Moon, Kwang Soo Kim, Bong Goo Yoo, Jong Kuk Kim, Min Jeong Kim
Kosin Med J. 2008;23(1):9-15.   Published online March 31, 2008
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Diabetic Oculomotor Nerve Palsy with Pupil Involvement
Ji Su Mun, Min Jeong Kim, Jong Kuk Kim, Bong Goo Yoo
Kosin Med J. 2008;23(1):51-53.   Published online March 31, 2008
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Intraventricular pneumocephalus After Lumbar Puncture
Sung Jin Kang, Jong Kuk Kim, Min Jeong Kim, Bong Goo Yoo, Kwang Soo Kim
Kosin Med J. 2007;22(2):165-167.   Published online December 31, 2007
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A case of Postpartum cerebral Angiopathy in Patient Receiving Bromocriptine
Sang Wook Ha, Sung Jin Kang, Min Jeong Kim, Jong Kuk Kim, Bong Goo Yoo, Kwang Soo Kim
Kosin Med J. 2007;22(1):147-150.   Published online June 30, 2007
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Two Cases of Hypokalemic Periodic Paralysis due to Primary Aldosteronism
Ji Hyun Lee, Ji Su Moon, Min Jeong Kim, Bong Goo Yoo, Kwang Soo Kim
Kosin Med J. 2005;20(1):72-75.
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Two Cases of Delayed Postanoxic Encephalopathy after Carbon Monoxide Intoxication
Min Jeong Kim, Kwang Soo Kim, Kyung Moo Yoo
Kosin Med J. 2000;15(1):112-117.
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Clinical study on Leptomeningeal Carcinomatosis
Meyung Kug Kim, Min Jeong Kim, Kwang Soo Kim, Kyung Moo Yoo
Kosin Med J. 1999;14(1-2):65-71.
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KMJ : Kosin Medical Journal