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Kwang Hyuk Kim 17 Articles
Effects of L-ascorbic acid on the production of pro-inflammatory and anti-inflammatory cytokines in C57BL/6 mouse splenocytes
Eun Hee Kong, Sun Young Ma, Jee Yeong Jeong, Kwang Hyuk Kim
Kosin Med J. 2015;30(1):41-49.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.1.41
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  • 13 Citations
Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Abstract Objective

The imbalance between pro-inflammatory and anti-inflammatory cytokines may underlie different pain states. Although ascorbic acid is the most important physiological antioxidant that affects host defense mechanisms and immune homeostasis, there is limited information on the effects of ascorbic acid on the production of cytokines.

Methods

In this study, we investigated the in vitro effect of L-ascorbic acid (AA) on the production of pro-inflammatory and anti-inflammatory cytokines by stimulating C57BL/6 mouse splenocytes with the polyclonal activators lipopolysaccharide or concanavalin A.

Results

AA significantly downregulated the expression of IL-6, IL-12, and TNF-α at 48 h and 72 h in mouse splenocytes treated with a combination of polyclonal activators and AA. AA treatment also resulted in upregulation of IL-4 and IL-10 at 72 h. These findings demonstrated that AA significantly potentiated production of anti-inflammatory cytokines whereas there was an inverse association between AA and expression of pro-inflammatory cytokines in mouse splenocytes.

Conclusion

AA may have potential applications in the reduction of inflammatory pain because of its function in modulating the production of cytokines. However, further in vivo investigations are necessary to elucidate the mechanisms involved.

Citations

Citations to this article as recorded by  
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  • STAT3 inhibition decreases ATP-induced MUC8 gene expression in human airway epithelial cells
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    Kosin Medical Journal.2022; 37(2): 134.     CrossRef
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    Gemala Anjani, Fitriyono Ayustaningwarno, Rafika Eviana
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    Antioxidants.2022; 11(10): 1993.     CrossRef
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    Open Access Macedonian Journal of Medical Sciences.2021; 9(A): 798.     CrossRef
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  • Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research
    Hui Yee Tan, Sik Loo Tan, Seow Hui Teo, Margaret M. Roebuck, Simon P. Frostick, Tunku Kamarul
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  • The potential cytoprotective effect of Vitamin C and Vitamin E on monosodium glutamate-induced testicular toxicity in rats
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    Alexandria Journal of Medicine.2020; 56(1): 134.     CrossRef
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    Respiratory Physiology & Neurobiology.2019; 270: 103265.     CrossRef
  • Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens
    Daniel Hernandez-Patlan, Bruno Solis-Cruz, Karine P. Pontin, Juan D. Latorre, Xochitl Hernandez-Velasco, Ruben Merino-Guzman, Abraham Mendez-Albores, Billy M. Hargis, Raquel Lopez-Arellano, Guillermo Tellez-Isaias
    Pathogens.2019; 8(4): 229.     CrossRef
  • Amelioration ofEscherichia coli-induced endometritis with ascorbic acid in non-pregnant mouse models
    Enitome Evi Bafor, Ikechukwu Onwukpa, Anne Oghenekevwe Itemire, Osemelomen Omoruyi, Ejiroghene Eferoba-Idio, Kevin Odega, Osas Jim Eghianruwa
    American Journal of Reproductive Immunology.2018; 80(3): e12976.     CrossRef
Effects of Capsaicin on the Production of Proinflammatory Cytokines in Mice
Kwang Hyuk Kim
Kosin Med J. 2008;23(4):58-63.   Published online December 31, 2008
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Inhibitory Effects of Berberine on Proliferation of Human Leukemia Cells
Eun Young Kim, Kwang Hyuk Kim
Kosin Med J. 2007;22(2):14-17.   Published online December 31, 2007
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Effects of Lidocaine and Propofol on Lymphocyte Proliferation in Mice
Su Ryoung Chung, Jong Seong Kim, Kwang Hyuk Kim
Kosin Med J. 2007;22(1):9-14.   Published online June 30, 2007
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Effects of Eucalyptus and Geranium on Tumor Cell Growth
Kwang Hyuk Kim
Kosin Med J. 2006;21(1):318-322.
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Growth Patterns of Methicillin Resistant Staphylococcus aureus in β-Lactam Antibiotic Containing Muller-Hinton Broth
Myung Hoon Joh, Kwang Hyuk Kim, Myung Woong Chang
The Journal of Kosin Medical College. 1992;8(2):105-134.
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The Influence of Linoleic acid and Ursolic Acid on Mouse Natural Killer Cell Activity
Kwang Hyuk Kim, Myung Woong Chang, Yangil Sunwoo
The Journal of Kosin Medical College. 1992;8(1):35-46.
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Antimicrobial susceptibility of Ureaplasma urealyticum
Myung Woong Chang, Kwang Hyuk Kim, In Dal Park, Gyung Sig Yoo, Seung Kyun Lim
The Journal of Kosin Medical College. 1991;7(1):25-38.
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Karyological Characteristics of K-56 Cells Infected with Ureaplasma urealyticum
Kwang Hyuk Kim, Gyung Sig Yoo, In Dal Park, Myung Woong Chang
The Journal of Kosin Medical College. 1990;6(2):135-146.
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Ureaplasma Infection of Human Chronic Myelogenous Leukemia Cell Line(K-562)
Kwang Hyuk Kim, Gyung Sig Yoo, In Dal Park, Myung Woong Chang
The Journal of Kosin Medical College. 1989;5(2):13-19.
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Chromosome Aberration of Human Lymphocyte Infected with Ureaplasma urealyticum
Myung Woong Chang, Kwang Hyuk Kim, In Dal Park, Gyung Sig Yoo
The Journal of Kosin Medical College. 1989;5(2):1-11.
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Electrom Microscopic studies on the Rise and Fall of Attached Ureaplasma urealyticum to Human Leukemia Cells
Myung Woong Chang, Kwang Hyuk Kim, In Dal Park
The Journal of Kosin Medical College. 1988;4(1):71-78.
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Isolation rates of Chlamydia trachomatis and Ureaplasma urealyticum from out-patients of obstetrics and Gynecology
Myung Woong Chang, Kwang Hyuk Kim, In Dal Park, Kee Muk Chung, Jae Hoon Chung
The Journal of Kosin Medical College. 1987;3(1):49-58.
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ANTIBIOTIC SUSCEPTIBILITY TEST AGAINST U. UREALYTICUM ISOLATED FROM CLINICAL SPECIMEN.
Myung Woong Chang, Kwang Hyuk Kim, In Dal Park, Kwang Sung Bae
The Journal of Kosin Medical College. 1987;3(1):43-48.
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Interferon Production in Human Lymphocyte Infected with Ureaplasma Urealyticum
Kwang Hyuk Kim, In Dal Park, Myung Woong Chang
The Journal of Kosin Medical College. 1986;2(1):31-36.
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Adherence of Ureaplasma Urealyticum to the Surface of Vero Cells
Myung Woong Chang, Kwang Hyuk Kim, In Dal Park
The Journal of Kosin Medical College. 1986;2(1):37-43.
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Effects of the Plant Growth Hormones on the Growth of Mycobacterium tuberculosis
yung-Woong Chang, Kwang Hyuk Kim, In Dal Park
The Journal of Kosin Medical College. 1985;1(1):19-24.
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KMJ : Kosin Medical Journal