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Jong In Kim 14 Articles
Analysis of an EGFR mutation by PNA clamping method in lung carcinoid tumors
Jong In Kim
Kosin Med J. 2015;30(2):141-147.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.2.141
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Abstract Background

Pulmonary carcinoid tumors consisting of typical carcinoid tumors (TC) and atypical carcinoid tumors (AC) are rare, accounting for 2–5% of all lung tumors. TC is considered a low-grade tumor with a rate of distant metastasis up to 12%. In contrast, ACs are more aggressive tumors, displaying a metastatic rate up to 70%. Surgery is the treatment of choice; however, the current treatment outcomes of metastatic lung carcinoids are discouraging. This study aimed to investigate the EGFR mutation using the PNA-mediated clamping method and to provide basic data for using EGFR-TK1 and its clinical implications.

Materials and Methods

A total of 14 cases that underwent surgery were diagnosed as carcinoid tumors and pathologically classified as TC and AC. The paraffin-embedded tissues were analyzed for EGFR mutations using the PNA-mediated PCR clamping technique. The mutant type was noted in the cases with aCt greater than 2.0.

Result

Of 14 cases, eight were AC and six cases were TC. No known EGFR mutation was detected with aCt less than 2.0.

Conclusion

The EGFR genotype determined using the PNA-mediated PCR clamping method was wild-type in all pulmonary carcinoid tumors. Therefore, the application of EGFR-TK1 is limited in pulmonary carcinoid tumors.

Citations

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  • STAT3 inhibition decreases ATP-induced MUC8 gene expression in human airway epithelial cells
    Cheol Hong Kim, Kyoung Seob Song
    Kosin Medical Journal.2022; 37(2): 134.     CrossRef
Post-traumatic tricuspid regurgitation with anterior papillary muscle rupture, corrected by papillary muscle reimplantation
Hae Young Lee, Sung Ho Cho, Jong In Kim
Kosin Med J. 2015;30(2):159-162.   Published online January 20, 2015
DOI: https://doi.org/10.7180/kmj.2015.30.2.159
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Abstract

A 60-year-old male patient with blunt chest trauma was transferred to our facility because of unstable vital signs and pericardial effusion. These conditions occurred after orthopedic surgery to repair multiple left finger fractures at a local medical center. Trans-thoracic echocardiography showed severe tricuspid regurgitation and he underwent papillary muscle reimplantation and tricuspid annuloplasty open heart surgery for post-traumatic tricuspid regurgitation with anterior papillary muscle rupture. We report early surgical traumatic valve disease correction without complications.

A Case of Squamous Cell Papilloma Suspected as Lung Cancer - 1 Case Report -
Jong In Kim
Kosin Med J. 2009;24(2):235-237.   Published online December 31, 2009
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Schwannoma of the Brachial Plexus
Jong In Kim
Kosin Med J. 2008;23(4):202-205.   Published online December 31, 2008
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Sleeve Resection of Carcinoid Tumor in Right Intermediate Bronchus
Jong In Kim
Kosin Med J. 2008;23(4):206-208.   Published online December 31, 2008
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Compelete Surgical Resection of Inoperable Chest Tumors After Intratumoral Injection of OK-432
Jong In Kim
Kosin Med J. 2008;23(4):209-212.   Published online December 31, 2008
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A Case of Parenchymal Hamartoma Suspected as Metastatic Lung Cancer - 1 Case Report-
Jong In Kim
Kosin Med J. 2008;23(4):213-215.   Published online December 31, 2008
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Expression of Melanoma Antigen Gene(MAGE) and Synovial Sarcoma on X Chromosome(SSX) in Sputum of Lung Cancer
Eon Sup Jung, Song Myung Kim, Jong In Kim
Kosin Med J. 2008;23(2):16-23.   Published online June 30, 2008
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Adjuvant Chemotherapy for Stage I Non-small Cell Lung Cancer
Dong Hyung Ha, Sung Rae Cho, Jong In Kim
Kosin Med J. 2007;22(1):151-159.   Published online June 30, 2007
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Changes of Acid-base and End-expiratory Carbon Dioxide Tension in Patients During Thoracic Surgery
Jong In Kim, Song Myung Kim
Kosin Med J. 2006;21(1):80-88.
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Clinical Analysis of Surgically Treated Pulmonary Aspergilloma
Jong In Kim, Sung Rae Cho
Kosin Med J. 2006;21(1):159-165.
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The Effects of Lung Cancer Cell Line in Spague Dowley Rats and Zucker's Obese Rats Using Subrenal Capsule Assay
Dong Suk Lee, Song Myung Kim, Jong In Kim, Jung Hoon Byun
Kosin Med J. 2005;20(1):76-87.
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The Outcome and Prognostic Factor of Surgically Resected Pulmonary Metastasis
Sung Rae Cho, Jong In Kim, Sung Ho Cho, Jung Hoon Byoun, Hae Young Lee, Sung Dal Park, Song Myong Kim
Kosin Med J. 2005;20(1):88-94.
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Thyroid Papillary Carcinoma in Intrathoracic Goiter
Bong Keun Lee, Sung Rae Cho, Bong Gyun Jo, Jong In Kim, Hae Young Lee, Hee Kyung Chang
Kosin Med J. 2002;17(1):166-169.
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KMJ : Kosin Medical Journal