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Jin-Hong Shin 1 Article
Predominant Myofibrillar Pathology with Preserved Sarcolemmal Aquaporin 4 Immunoreactivity in a Patient with Neuromyelitis Optica-Associated HyperCKemia
So-Young Huh, Jin-Hong Shin, Yeong-Eun Park, Ho Jin Kim, Dae-Seong Kim
Kosin Med J. 2021;36(2):206-210.   Published online December 31, 2021
DOI: https://doi.org/10.7180/kmj.2021.36.2.206
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Abstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM

A 49-year-old man developed recurrent myalgia and hyperCKemia during acute attacks of neuromyelitis optica. Muscle biopsy was performed, and the pathological findings were analyzed. Predominant myofibrillar pathology was observed, which constitutes a unique finding that has not been reported before. This case result shows that neuromyelitis optica-associated hyperCKemia can produce variable pathologic phenotypes. Further studies are needed to elucidate the relationship between myofibril destruction and aquaporin 4 autoimmunity.


KMJ : Kosin Medical Journal